IBS: Salmonella and Probiotics as Immunobiotic
Dear Friend,
Infection with Salmonella is a known risk factor for Irritable Bowel Syndrome (IBS) and other inflammatory, digestive and gastrointestinal distress.
In a recent research, Kanmani & Kim (2020) studied Lactobacillus strains and their potential reduction of inflammatory response caused by Salmonella. That is good news for sufferers of IBS.
From IBS to other dis-eased conditions in the body, modulating the immune system with Lactic Acid bacteria (LAB) strengthen the body's response to invaders and inflammation causing diseases such as IBS or cancer.
The field of immuneobiotics - probiotics used to boost the immune response is widely researched and Lactobacillus and Bifidobacterium probiotics are showing excellent results ( Aindelis & Chlichlia, 2020). Full article in the reference list. Enjoy!
Abstract:
There is a growing amount of evidence to support the beneficial role of a balanced intestinal microbiota, or distinct members thereof, in the manifestation and progression of malignant tumours, not only in the gastrointestinal tract but also in distant tissues as well. Intriguingly, bacterial species have been demonstrated to be indispensable modulatory agents of widely-used immunotherapeutic or chemotherapeutic regiments. However, the exact contribution of commensal bacteria to immunity, as well as to neoplasia formation and response to treatment, has not been fully elucidated, and most of the current knowledge acquired from animal models has yet to be translated to human subjects. Here, recent advances in understanding the interaction of gut microbes with the immune system and the modulation of protective immune responses to cancer, either naturally or in the context of widely-used treatments, are reviewed, along with the implications of these observations for future therapeutic approaches. In this regard, bacterial species capable of facilitating optimal immune responses against cancer have been surveyed. According to the findings summarized here, we suggest that strategies incorporating probiotic bacteria and/or modulation of the intestinal microbiota can be used as immune adjuvants, aiming to optimize the efficacy of cancer immunotherapies and conventional anti-tumour treatments. View Full-Text
Sincerely yours,
Seann
References
- Aindelis, G., & Chlichlia, K. (2020). Modulation of anti-tumour immune responses by probiotic bacteria. Vaccines, 8(2), 329.
- Kanmani, P., & Kim, H. (2020). Beneficial effect of immunobiotic strains on attenuation of Salmonella induced inflammatory response in human intestinal epithelial cells.Plos one, 15(3), e0229647. Full-Article
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