Reversal of Age? NAD+ from Polyphenol

Henderson et al. (2024) proposed to use systems approach to increase NAD+ which then  will increase the body's ability to repair and boost anti-aging properties. 

In fact, the systems are different pathways that target NAD+ in the body, from the wholeness of foods. What did the researchers find? An increase in SIRT1 and nicotinamide phosphoribzosyltransferase (NAMPT) and lower concentrations of pro-inflammatory cytokines in plasma, boost of immune system  - all pointing at a 'younger biological age' for feeling and looking better.

And here is the interesting part about this study - the researchers used very few polyphenols with low dosage of vitamin C, zinc and B3. Yet the world of polyphenols is huge, so what did they miss?

Quite a lot.

Tovar-Palacio et al. (2022) lead the way with a long list of polyphenols for their research on restoring NAD+ and SIRT1. And just as a reminder, SIRT1 protects against neurogenrative disease and is important in the body ability to regulate gene expression with its influence on antioxidant and anti inflammation among other processes.

What foods then help to maintain the equilibrium between oxidation/anti-oxidation and inflammation/anti-inflammation? Polyphenols and in particular stilbene, resveratrol, flavonoid, and more. 

Enjoy the articles! 

High ORAC Synbiotic 

Yours as always,

Dohrea 

References 

• Henderson, J. D., Quigley, S. N., Chachra, S. S., Conlon, N., & Ford, D. (2024). The use of a systems approach to increase NAD+ in human participants. npj Aging, 10(1), 7. Article
• Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential synergistic supplementation of NAD+ promoting compounds as a strategy for increasing healthspan. Nutrients, 15(2), 445. Article
• Tovar-Palacio, C., Noriega, L. G., & Mercado, A. (2022). Potential of polyphenols to restore SIRT1 and NAD+ metabolism in renal disease. Nutrients, 14(3), 653. Article

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