Together, let’s put an end to deteriorating health

Pyschobiotics and Hormesis: Combat Stress, Depression, and Aging

Pychobiotics are specific probiotics that show in research promising therapeutic benefits - by reducing depressive symptoms and anxiety (Ross, 2023). 

Essentially, these foundational Probiotics enhance our psychological state! 

As I thought about Hormesis and its role in helping us adapt and even evolve, I wondered if there is research that actually combines both hormesis and pychobiotics?

And of course, if we think of something so do others, and indeed there is exciting research that combines these two concepts in theory and in practice. 

What is unique about using the hormesis concept with probiotics and plant polyphenols (with other nutrients)?

Remember, hormesis is the use of small dosages of certain materials (such as nutrients or even toxic materials) to create a boost in immunity or strengthen mechanism, or simply create a small elegant shift in the body that affects everything else (the domino effect). 

Both probiotics and polyphenols are natural part of our body's milieu (internal environment) and mechanism. We change internally and naturally as part of our biology and psychology when we  ingest materials that are already part of who we are and how we are designed. Our bodies already have receptor cites for polyphenols and certainly we are made up of trillion organisms. 

Beautiful isn't it?

So what can happen when we combine pyschobiotics with hormetic nutrients to engage and combat the three elements that affect our health: stress, our psychology or in other words, mental and emotional state of being (e.g., depression), and the chronic illnesses from the aging process (inflammation, oxidation, low immunity etc.)? 

Sabrina Donati Zeppa and her team of researchers from the Department of Biomolecular Sciences in the University of Urbino Carlo Bo, Italy, have set out to study the effect of polyphenols and pychobiotics - exerting hormetic effect on the gut microbiome to alleviate depression (Zeppa et al., 2022). 

Since the brain and gut have bidirectional communication, and a continuous one, creating a change in one center will affect the communications and biology of the other center. 

To instigate further change and a hormetic effect, Zeppa et al. included exercise to reduce stress and depression and give more oomph to both probiotics and polyphenols. 

The interrelationship between probiotic and polyphenols is important to gut - brain axis, adding exercise to the mix increases growth and production of probiotics in the gut, activating the vagus nerve, modulating neurotransmitters metabolism (e.g., tryptophan's which is converted to serotonin in the gut), reduce inflammation, and more (Zeppa et al., 2022). 

When we combat stress and depression, create harmony between gut and brain, we slow down the aging process and with it a host of chronic conditions. 

A clear, concise, and detailed article. Enjoy! Article

No 7 Systemic Booster


Mix 1 teaspoon with a shot of diluted juice, or water. Every day.

Potent polyphenols- Organic berries, fruits, hardy vegetables, and green leafy vegetables: strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, broccoli florets, kale leaves, spinach leaves. ProbioticsProbioticsLactobacillus plantarum, Lactobacillus paracasei, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactic, Bifidobacterium longum, Streptococcus thermophilus and Lactobacillus bulgaricusSupernatant- probiotic metabolites, and ORNsPrebioticsInulin from Chicory Root along with Fibers- from organic veggies, greens, fruits, and berries. Vital Nutriceuticals- Fructo Borate, Vitamin B12, Vitamin D3, Folate, Chromium.


  • Donati Zeppa, S., Ferrini, F., Agostini, D., Amatori, S., Barbieri, E., Piccoli, G., ... & Stocchi, V. (2022). Nutraceuticals and physical activity as antidepressants: The central role of the gut microbiota. Antioxidants11(2), 236. Article
  • Ross, K. (2023). Psychobiotics: Are they the future intervention for managing depression and anxiety? A literature review. EXPLORE. Article
  • Sharma, V., & Mehdi, M. M. (2023). Oxidative stress, inflammation and hormesis: The role of dietary and lifestyle modifications on aging. Neurochemistry International, 105490. Article 

    Yours as always,


    We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.


    Green Facts:

    Globe_Home 3

    And more on hormesis: 

    Le Bourg, E. (2009). Hormesis, aging and longevity. Biochimica et Biophysica Acta (BBA)-General Subjects, 1790(10), 1030-1039.

    ©2005 - 2023 BioImmersion Inc. All Rights Reserved.

    Net Orders Checkout

    Item Price Qty Total
    Subtotal $0.00

    Shipping Address

    Shipping Methods