Together, let’s put an end to deteriorating health

Polyphenols: Modulators of Age Related Diseases

Polyphenols are now believed to be one of the best modulators for the 'biomarkers' of aging and disease.

We continue our conversation on the informative research article of Meccariello & D’Angelo (2021):  reversing aging related diseases and feeling good  and even younger once again.

Meccariello and D'Angelo present studies that polyphenols, with their antioxidant and anti-inflammatory abilities, can affect telomere length and prevent shortening as far as probable and thus have powerful anti-aging capabilities.

Here is one of their paragraphs to illustrate the powerful effect of polyphenols:

Several reports highlighted that dietary supplementation of polyphenols may defend against neurodegenerative, cardiovascular, metabolic syndromes, inflammatory, and cancer by enhancing Sirt-1 deacetylase action. Sirtuins are a class of nutrient-sensitive epigenetic information regulators, including in promoting mammalian health, modulating cellular senescence and lifespan, and Sirt1 is called the longevity gene. Sirt1 is a (NAD+)-dependent deacetylase that targets a number of transcription factors, such as fork head box transcription factor (FOXO) 1, 3, and 4, p53, nuclear factor NF-κB, and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1), moderating in turn a number of cellular stress adaptive responses. Sirt1 can deacetylase p53 in a NAD+-dependent manner to impede p53 transcription, modulating pathways involved in cellular and organismal aging (Ong & Ramasamy, 2018).

Foods like with catechizes and polyphenols increase Sirt1-1 levels and improve cognition, so add blueberries, grape seeds, strawberries, apples gooseberries, green tea, cacao and more. 



  • Meccariello, R., & D’Angelo, S. (2021). Impact of polyphenolic-food on longevity: an elixir of life. An overview. Antioxidants10(4), 507. Article
  • Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018). Hallmarks of cellular senescence. Trends in cell biology28(6), 436-453.Article
  • Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome biology14(10), 1-20. Article
  • Ong, A. L., & Ramasamy, T. S. (2018). Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. Ageing research reviews43, 64-80. Abstract


Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.


Green Facts:

Globe_Home 3

Duan, H., Pan, J., Guo, M., Li, J., Yu, L., & Fan, L. (2022). Dietary strategies with anti-aging potential: dietary patterns and supplements. Food Research International, 111501. Abstract


 ©2005 - 2022 BioImmersion Inc. All Rights Reserved

Net Orders Checkout

Item Price Qty Total
Subtotal $0.00

Shipping Address

Shipping Methods