Polyphenols: Modulators of Age Related Diseases
Here is one of their paragraphs to illustrate the powerful effect of polyphenols:
Several reports highlighted that dietary supplementation of polyphenols may defend against neurodegenerative, cardiovascular, metabolic syndromes, inflammatory, and cancer by enhancing Sirt-1 deacetylase action. Sirtuins are a class of nutrient-sensitive epigenetic information regulators, including in promoting mammalian health, modulating cellular senescence and lifespan, and Sirt1 is called the longevity gene. Sirt1 is a (NAD+)-dependent deacetylase that targets a number of transcription factors, such as fork head box transcription factor (FOXO) 1, 3, and 4, p53, nuclear factor NF-κB, and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1), moderating in turn a number of cellular stress adaptive responses. Sirt1 can deacetylase p53 in a NAD+-dependent manner to impede p53 transcription, modulating pathways involved in cellular and organismal aging (Ong & Ramasamy, 2018).
Foods like with catechizes and polyphenols increase Sirt1-1 levels and improve cognition, so add blueberries, grape seeds, strawberries, apples gooseberries, green tea, cacao and more.
- Meccariello, R., & D’Angelo, S. (2021). Impact of polyphenolic-food on longevity: an elixir of life. An overview. Antioxidants, 10(4), 507. Article
- Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018). Hallmarks of cellular senescence. Trends in cell biology, 28(6), 436-453.Article
- Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome biology, 14(10), 1-20. Article
- Ong, A. L., & Ramasamy, T. S. (2018). Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. Ageing research reviews, 43, 64-80. Abstract
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Duan, H., Pan, J., Guo, M., Li, J., Yu, L., & Fan, L. (2022). Dietary strategies with anti-aging potential: dietary patterns and supplements. Food Research International, 111501. Abstract
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