Polyphenols: Modulators of Age Related Diseases
Here is one of their paragraphs to illustrate the powerful effect of polyphenols:
Several reports highlighted that dietary supplementation of polyphenols may defend against neurodegenerative, cardiovascular, metabolic syndromes, inflammatory, and cancer by enhancing Sirt-1 deacetylase action. Sirtuins are a class of nutrient-sensitive epigenetic information regulators, including in promoting mammalian health, modulating cellular senescence and lifespan, and Sirt1 is called the longevity gene. Sirt1 is a (NAD+)-dependent deacetylase that targets a number of transcription factors, such as fork head box transcription factor (FOXO) 1, 3, and 4, p53, nuclear factor NF-κB, and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1), moderating in turn a number of cellular stress adaptive responses. Sirt1 can deacetylase p53 in a NAD+-dependent manner to impede p53 transcription, modulating pathways involved in cellular and organismal aging (Ong & Ramasamy, 2018).
Foods like with catechizes and polyphenols increase Sirt1-1 levels and improve cognition, so add blueberries, grape seeds, strawberries, apples gooseberries, green tea, cacao and more.
References
- Meccariello, R., & D’Angelo, S. (2021). Impact of polyphenolic-food on longevity: an elixir of life. An overview. Antioxidants, 10(4), 507. Article
- Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018). Hallmarks of cellular senescence. Trends in cell biology, 28(6), 436-453.Article
- Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome biology, 14(10), 1-20. Article
- Ong, A. L., & Ramasamy, T. S. (2018). Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. Ageing research reviews, 43, 64-80. Abstract
Sincerely yours,
Dohrea
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Green Facts:
Duan, H., Pan, J., Guo, M., Li, J., Yu, L., & Fan, L. (2022). Dietary strategies with anti-aging potential: dietary patterns and supplements. Food Research International, 111501. Abstract
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