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Plant Polyphenols as Second-Generation Synbiotic

Synbiotic formulas have probiotics and some form of plant fiber called prebiotics. Seann has posited two decades ago that polyphenols are actually one of the best companions to probiotics. We built a whole line of unique probiotics with very specific plant-polyphenols to enact different functions in our body. 

Fiber is important for the gut, it has many attributes one of which is helping probiotics create a woven matrix in the colon so they can grow.  Or as one of our scientists liked to describe it: build a good matrix for growth and housekeeping (got to clean out unwanted organism in the 'house').

This of course is a simplistic way of visualizing what goes on in the gut - but you do get the picture! 

So how do these polyphenols affect our gut and overall health? And what is important to keep in mind? Do we need fiber and plants with our probiotics? 

In a 2020 systematic review Alves-Santos et al. examine the prebiotic effects and reasons dietary polyphenols are important for gut health. For example: Catechins, anthocyanins and proanthocyanidins increase the growth rate of Lactobacillus and Bifidobacterium among others, as well as increase production of short-chain fatty acids 9SCFA), including Butyrate. The list of excellent health benefits is long. 

Keep in mind that our scientific community keep expanding and growing into a more holistic framework and are studying diligently how these plant and dietary ingredients affect our health. 

Enjoy this review! 


Prebiotics are substrates selectively metabolized by hindgut microorganisms conferring health benefits. Recent studies suggest polyphenols as candidate to prebiotics. Thus, this systematic review aimed to investigate the prebiotic effect of dietary polyphenols in preclinical and clinical studies. Animal studies demonstrated that the consumption of polyphenols, especially catechins, anthocyanins and proanthocyanidins, increases the abundance of LactobacillusBifidobacteriumAkkermansiaRoseburia, and Faecalibacterium spp. Moreover, polyphenols supplementation increased the production of short-chain fatty acids (SCFA), including butyrate. The included clinical trials showed an increased abundance of Lactobacillus acidophilusBifidobacterium and Faecalibacterium spp., and a reduction in plasma lipopolysaccharide-binding protein after the consumption of anthocyanins and ellagic acid. In conclusion, there is strong evidence in preclinical studies that dietary polyphenols can stimulate both the growth of microorganisms identified as prebiotic targets and an increase in the production of SCFA. Therefore, clinical trials are warranted to investigate the prebiotic effect of dietary polyphenols on humans. Article


 High ORAC Synbiotic

 High ORAC Synbiotic

Polyphenols with a very high Total ORAC and probiotics:  1 capsule a day. We also suggest the High ORAC for post antibiotic care, precisely because of its antimicrobial potential.   


  • Alves-Santos, A. M., Sugizaki, C. S. A., Lima, G. C., & Naves, M. M. V. (2020). Prebiotic effect of dietary polyphenols: A systematic review. Journal of Functional Foods74, 104169. Article
  • Banerjee, A., & Dhar, P. (2019). Amalgamation of polyphenols and probiotics induce health promotion. Critical reviews in food science and nutrition59(18), 2903-2926. Abstract 


    Sincerely yours,


    We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.


    Green Facts:

    Globe_Home 3I thought to leave this article for you as elephants are so precious.  NY Times shared this article:  Elephants are being hunted down and the US allows to important some elephant trophies:



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