Obesity/Diabetes and Inflammation
Chronic tissue inflammation goes hand-in-hand for people suffering from obesity and diabetes. The inflammatory cytokine Tumor Necrosis Factor Alpha (TNF-a) is elevated in the plasma and adipose tissue of these individuals. TNF-a induces the expression of inflammatory genes such as IL-6, IL-1B, IL-8 and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8 and MCP-1. Hence, chronic inflammation.
Chuang et al, 2010 research aim was to examine the extent to which quercetin and resveratrol prevent inflammation or insulin resistance in primary cultures of human adipocytes. What they found was that quercitin is equally or more effective than resveratrol in attenuating TNF-a mediated inflammation and insulin resistance in fat cells.
Therapeutic Food protocol to support reduction of inflammation:
- Phyto Power, wild crafted– 1-2 capsules BID.
Phyto Power contains a powerhouse of anti-inflammatory phytochemicals including quercitin and resveratrol. Supplying Alaskan wildcrafted, high phenolic actives produce— namely three species of rosehips (whole fruit seeds and all), four species of blueberry (high and low bush) and four species of dandelion (with roots, leaves and flowers).
The wilds of Alaska provide an amazing environment for powerful plants and berries— fertile volcanic ash soil, and a harsh environment that challenges plants to put out high levels of phenols (e.g. flavonoids) to protect themselves.
Notice the different between an Alaskan rosehip and the typical European rosehip (dog-rose) in terms of their phytonutrient load.
- Quercetin- 10.50 (Alaskan rosehip) versus 1.05 (European rosehip) in mg/g.
- Hyperoside- 3.03 versus 4.30
- Kaempferol- 1.62 versus 0.00
- Isoquercitin- 0.78 versus 3.51
- Naringenin- 0.26 versus 0.15
- Rutin- 0.16 versus 0.67
- Nothofagrin- 0.26 versus 0.07
- Luteolin- 0.02 versus 0.01
- Biochanin A- 0.02 versus 0.00
- Catechin- 72.5 versus 35.70
- Epicatechin- 67.50 versus 33.70
- Gallocatechin- 0.93 versus 0.86
- Epicatechin gallate- 0.45 versus 0.15
- Catechin gallate- 0.25 versus 0.02
- Ellagic acid- 48.30 versus 5.25
- Gallic acid- 7.85 versus 0.14
- p- Coumaric acid- 1.54 versus 0.16
- Protocatachuic acid- 0.97 versus 0.18
- Caffeic acid- 0.38 versus 0.00
- Chlorogenic acid- 0.30 versus 0.05
- Salicylic acid- 0.22 versus 0.14
- Fefulic acid- 0.06 versus 0.09
- Vitamin C- 25.00 versus 10.00
- Vitamin B3- 1.09 versus 0.19
- Vitamin B2- 0.08 versus 0.11
- Vitamin B1- 0.03 versus 0.01
- Vitamin B6- 0.01 versus 0.00
- Lycopene- 4.89 versus 2.98
- b-Carotene- 1.15 versus 1.53
- Lutein- 0.21 versus 0.00
- Zeaxanthin- 0.17 versus 0.19
So as you can see there is a large quantative difference, which directly corresponds to therapeutic efficacy.
Quercitin may help protect against heart disease and cancer as well.. Quercetin can also help stabilize the cells that release histamine in the body and thereby have an anti-inflammatory and antihistamine effect.
- Chuang et al. (2010). Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-(alpha)-mediated inflammation and insulin resistance in primary human adipocytes. Am J Clin Nutr; 92(6): 1522-21.
- Dower et al. (2014). Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized double-blind, placebo-controlled, crossover trial. Am J Clin Nutr; 101(5): 914-21.
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.