New Research: Chromium Targets Neuroinflammatory Pathways in the Brain

Dear Friend,

Alzheimer’s Disease (AD) brings suffering for many families around the world. It is too prevalent. According to a recent research, brain insulin resistance, neuroinflammation, and oxidative stress are key feature for AD.

There are promising solutions with one of them being the careful monitoring of blood sugar. Chromium picolinate was used in this research with rats and compared with other drugs, showing the chromium performed with better success (Akhtar et al., 2020).   

The Weight-Less is an important addition to Chromium, with potent Brown Seaweed extract. Taken 20 minutes before meals, the extracts slow down the absorption of carbohydrates, lowering the glycemic index and reducing blood glucose for overall glycemic control (Haskell-Ramsay et al., 2018; Paradis et al., 2011; Roy et al., 2011).

Abstract

Alzheimer's disease (AD) is prevalent in old age people and is one of the most common brain diseases. Brain insulin resistance, neuroinflammation, oxidative stress, and mitochondrial and cholinergic dysfunction are key features of the disease. In our study, streptozotocin (STZ) in a dose of 3 mg/kg was injected in male Wistar rats bilaterally through the intracerebroventricular (ICV) route on stereotaxic apparatus. Chromium picolinate (CrPic) was tested at doses of 1 mg/kg, 2 mg/kg, and 4 mg/kg, while rivastigmine (2 mg/kg) was used as reference standard drug. Cognitive dysfunction induced by STZ was assessed by behavioral tests like Morris water maze and novel object recognition test. Treatment with CrPic revealed attenuation of cognitive deficit. This was confirmed by behavioral tests, biochemical estimations of antioxidant enzymes, oxidative stress, nitrosative stress, and cholinergic and mitochondrial activity. CrPic did not change AchE activity significantly. STZ-induced neuroinflammation evident by increased TNF-α, IL-6, and CRP levels was also significantly decreased by CrPic. Dysfunctional insulin signaling after ICV-STZ was demonstrated by reduced IRS-1, PI3K, AKT, BDNF gene expression, and increased GSK-3β, NF-κB gene expression with the help of qRT-PCR. CrPic treatment produced an improvement in insulin signaling revealed by increased gene expression of IRS-1, PI3-K, AKT, BDNF, and decreased gene expression of GSK-3β and NF-κB. It was concluded that CrPic reversed AD pathology revealed by improved memory, reduced oxidative stress, neuroinflammation, mitochondrial dysfunction, and upregulated insulin signaling. Abstract

Chromium with High Active Beet Root 

Chromium with High Active Beet Root  

Suggested use: 1 capsule daily

Weight-Less 

Suggested use: 1capsule, 20 minutes before meals.

Sincerely yours,

Seann

References

• Akhtar, A., Dhaliwal, J., Saroj, P., Uniyal, A., Bishnoi, M., & Sah, S. P. (2020). Chromium picolinate attenuates cognitive deficit in ICV-STZ rat paradigm of sporadic Alzheimer’s-like dementia via targeting neuroinflammatory and IRS-1/PI3K/AKT/GSK-3β pathway. Inflammopharmacology, 28(2), 385-400. Abstract

• Gabbia, D., Dall’Acqua, S., Di Gangi, I. M., Bogialli, S., Caputi, V., Albertoni, L., ... & De Martin, S. (2017). The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. Marine drugs, 15(2), 41.
• Haskell-Ramsay, C. F., Jackson, P. A., Dodd, F. L., Forster, J. S., Bérubé, J., Levinton, C., & Kennedy, D. O. (2018). Acute post-prandial cognitive effects of brown seaweed extract in humans. Nutrients, 10(1), 85. Article
• Roy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., & Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo. Food research international, 44(9), 3026-3029. 
• Wiśniewska, P., Czyżewska, I., & Jarosz, P. M. (2020). The range of possible chromium III applications in medicine-the short review. Journal of Education, Health and Sport, 10(8), 286-290. Abstract

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