Microbiome, Mythology, and Humanity

Dear Friends

Protect the gut from dysbiosis by adding good probiotics.

We are going through a phenomenal paradigm shift realizing who and what we really are; this in large part is due to the National Institute of Health (NIH) and the Human Microbiome Project (HMP).

What is this new paradigm?  Francis Collins, the Director of NIH, explains: “We should think of each host [human] and its parasites [microbiome] as a superorganism with the respective genomes yoked into a chimera of sorts” (2015, talk titled: Supercharging Science for the Superorganism). Humans are creatures of mythology.

Many researchers agree. Moeller et al. (2014) declares, “Humans are ecosystems containing trillions of microorganisms.”  Michael Pollen’s (2013) lecture at the University of Colorado, Some of my best friends are germs, summarized, “It turns out that we are only 10% human: for every human cell that is intrinsic to our body, there are about 10 resident microbes … to the extent that we are bearers of genetic information, more than 99% of it is microbial.”

Our GI tract alone is home to around 100 trillion bacteria, and that’s not counting viruses, yeast, and other microbes.  They bring 8 million bacterial genes to cohabitate with our 22,000 genes (Rob Knight’s 2015 Keystone Symposia talk, Development of the Human Microbiome).

Needless to say, the composition and makeup of the ecosystem of our gastrointestinal tract is incredibly important to our overall health and wellbeing, and dysbiosis is a condition where pathogenic microbial populations are not in harmony. The idea is that as creatures of many different life forms, we must learn to create harmonious working relations.

Therapeutic Food recipe to support a healthy GI tract microbiome, choose one or combine and interchange:

• Original Synbiotic: 1 tsp daily
• Beta Glucan High Potency Synbiotic: 1 tbl daily
• High ORAC Synbiotic: 1-2 capsules daily

Food Science

The importance of bringing in useful strains of probiotic organisms into our diet cannot be overstated. Knowing your strains and their strengths is critical.  Secondly, having top microbiologists in your probiotic growing operation is important in order to achieve the maximum genetic potential of the carefully selected strains.  How the bugs are grown and harvested matters as to their strength.  And, thirdly, having the latest technology to accurately type the genomes of each batch of product to assure their genomic fidelity.

For example there are differences between strains of same species in certain important attributes. These include tolerance to acid, bile and pancreatin (Masco, 2007); adherence to mucus or to epithelial cells (Adlerberth et al., 1996; Pretzer et al., 2005; Collado et al. 2005; Tallon et al., 2007); enzymatic activity (Rao & Dutta, 1978); and antibiotic resistance or production of antimicrobial compounds (Olivares et al., 2006; D’Aimmo et al., 2007).

Original Synbiotic contains Lactobacillus acidophilus ATCC 4355, Lactobacillus plantarum ATCC 8014, Lactobacillus rhamnosus ATCC 7469, Steptococcus thermophilus 19258 and Bifidobacteria longum ATCC 15707, along with organic chicory root soluble fiber- inulin.  

ATCC (American Type Collection Collection) is the largest repository for bacterial collections in the world and provides the Gold Standard for genomic typing and mother culture storage.
Our probiotics are all ATCC prototypical bacterial strains with confirmed molecular identity, and demonstrate strong abilities to survival stomach acidity, and the bile and pancreatin of the small intestines.

Collectively, these specific strains have shown not only good ability to colonize and protect the epithelial GI tract mucus membrane from pathogenic organisms but are able to neutralize dietary toxins, mutagens, carcinogens and infectious organisms.  They aid in digestion, enhance absorption of minerals, are strong producers of the SCFA butyrate.  (Click above on the link above to see the Originals Synbiotic Monograph)

Beta Glucan High Potency Synbiotic contains the same powerful pedigreed probiotics as the Original but has a higher CFU and a wider collection of prebiotic fibers especially the beta gluten soluble fibers derived from gluten free oat bran. (See the technical brief on this product in the link above)

High ORAC Synbiotic contains a CFU of 20 billion probiotic (L. acidophilus, B.longum) plus blueberry extract, grape and grape seed extract, raspberry and raspberry seed extract, cranberry, strawberry, prune, tart cherry and wild bilberry extract plus 250mg inulin.
(Read more by clicking on the link above to see the High ORAC Synbiotic Monograph).

Select any one of these synbiotics to support your health promoting needs.

Bibliography

• Adlerberth et al. (1996). A mannose-specific adherence mechanism in Lactobacillus plantarum conferring binding to the human colonic cell line HT-29. Appl Environ Microbiol; 62: 2244-2251.
• Collado et al. (2007). Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol; 45(4): 454-460.
• D’Aimmo et al. (2007). Antibiotic resistance of lactic acid bacteria and Bifidobacterium spp. isolated from dairy and pharmaceutical products. Int J Food Microbiol; 115(1): 35-42.
• Marteau, P. (2011). Evidence of probiotic strain specificity makes extrapolation of results impossible from a strain to another, even fro the same species. Annals of Gastroenterology & Hepatology; 2(1): 34-36.
• Masco et al. (2007). In vitro assessment of the gastrointestinal transit tolerance of taxonomic reference strains from human origin and probiotic product isolates of Bifidobacterium. J Dairy Sci; 90(8): 3572-3578.
• Medine et al. (2007). Differential immunomodulatory properties of Lifidobacterium longum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol; 150(3): 531-538.
• Moeller et al. (2014). Rapid changes in the gut microbiome during human evolution PNAS; 111(46): 16431-16455
• Olivares et al. (2006). Antimicrobial potential of four Lactobacillus strains isolated from breast milk. J Appl Microbiol; 101(1): 72-79.
• Pretzer et al. (2005). Biodiversity-based identification and functional characterization of the mannosespecific adhesion of Lactobacillus plantarum. J Bacteriol; 187: 6128-6136.
• Rao MV, Dutta SM. Lactase activity of microorganisms. Folia Microbiol (Praha); 23(3): 210-215.
• Tallon et al. (2007). Strain- and matrix-dependent adhesion of Lactobacillus plantarum is mediated by proteinaceous bacterial compounds. J Appl Microbiol; 102(2): 442-451.
• Yoshimura et al. (2010). Prevention of Escherichia coli O157:H7 infection in gnotobiotic mice associated with Bifidobacterium strains. Antonie Van Leewenhoek; 97(2): 107-117.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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