Key for Treating Alzheimer’s- SIRT1
Dear Friends
Alzheimer’s has moved up to the number three cause of death in the United States just under cancer and heart disease (NIH- National Institute of Aging, 2019).
Julien et al. (2009) compared the concentration of SIRT1 in the brains of AD patients and controls. In the first group of 19 patients and 22 controls, a significant reduction of SIRT1 in the parietal cortex of AD patients was found. Further analyses in a second cohort of 36 subjects confirmed that cortical SIRT1 was decreased in AD but not in individuals with mild cognitive impairments. A significant relationship between SIRT1 levels and global cognition scores proximate to death was also found. Collectively, their results indicate that loss of SIRT1 is closely associated with the accumulation of amyloid-beta and tau in the cerebral cortex of persons with AD. Furthermore, autopsies of Alzheimer’s victims reveal that loss of sirtuin enzyme activity is closely associated with the accumulation of the plaques and tangles.
Plants (fruits, berries, veggies, and greens) contain key phytonutrients, namely polyphenols. In research, an increasing number of polyphenols are being found to turn on a family of our anti-aging genes called sirtuins. Sirtuins, particularly SIRT1 expression, is shown to reduce and eliminate amyloid-B and tangles, two protein derangements that are symptomatic of Alzheimer’s. High heat cooked meats and fats create a molecule called advanced glycation end products (AGEs) which when present in the blood turn off the sirtuin gene expression, thereby turning off the expression of these anti-aging genes (Julien et al., 2009).
The Therapeutic Food Supplements boost our body with key plant polyphenols that turn on the sirtuins. Each of the four products is designed to supply ample amounts of phytonutrients and in particular polyphenols such as resveratrol, quercetin, and catechins to enhance brain function.
For preventing cognitive decline and beginning stages of dementia, add to your protocol the High ORAC Synbiotic with standardized high levels of resveratrol and quercetin.
For a progressive decline and Alzheimer’s, add to the High ORAC a more robust protocol of powerful polyphenols to regenerate neurons in the brain:
References:
- Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology,18(4), 447-476.
- Julien, C., Tremblay, C., Emond, V., Lebbadi, M., Salem Jr, N., Bennett, D. A., & Calon, F. (2009). Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 68(1), 48-58.
- Uribarri, Jaime, Sandra Woodruff, Susan Goodman, Weijing Cai, Xue Chen, Renata Pyzik, Angie Yong, Gary E. Striker, and Helen Vlassara. (2010). “Advanced glycation end products in foods and a practical guide to their reduction in the diet.” Journal of the American Dietetic Association110, no. 6: 911-916.
To your health,
Seann
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Green Facts:
Our diet is a major factor in whether we succumb to Alzheimers or not. Eating primarily a whole-foods plant-based diet with meat and fat being more like a condiment puts the odds highly in one’s favor on not becoming its victim (Uribarri et al., 2010). . |
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