Inflammation in the Gut and Heart Failure

Is it possible that inflammation in the gut contribute to cardiac dysfunction and eventually to heart failure? 

The team of Matsiras et al., (2023) examined the exact pathophysiological mechanisms between a 'disrupted composition' of the microbiota, harmful metabolites that are created by unfavorable organisms in the gut, and gut barrier disruption - and heart failure. 

The conclusion is that intestinal dysfunctions could very well be the underlying condition of heart failure. 

The study of pathophysiological mechanisms is focused on the typical physiological functions and processes that lead to health or disease. Pathology looks at how the body behaves (processes and conditions) when disease is present while physiology is the study of the typical mechanisms of a normal functioning body (human, animal, organism). Combine these together and you have the a deeper study of how and why disease is created in the body - or what physiological processes do we look for to explain a diseased state. 

Matsiras et al., (2023) is an excellent Article. Some of their therapeutic interventions are well known and some are more novel or pharmaceutical in nature. One of the lessons here is that simple life style interventions, like eating more vegetables and fruits (fiber, polyphenols, and high antioxidants), less meat, adding certain probiotics, and prebiotics to produce more butyrate in the gut, can interrupt the pathway toward heart failure. 

And as always, we need more research and understanding. 

Enjoy! 

Beta Glucan Synbiotic: Heart - Gut Axis

Yours as always,

Dohrea 

References

• Matsiras, D., Bezati, S., Ventoulis, I., Verras, C., Parissis, J., & Polyzogopoulou, E. (2023). Gut Failure: A Review of the Pathophysiology and Therapeutic Potentials in the Gut–Heart Axis. Journal of Clinical Medicine, 12(7), 2567. Article

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My Research: International Day of Peace. 9.20.24