Inflammation and Aging

Dear Friends,

Let’s continue our discussion on achieving longevity: What are the reason(s) behind the design of the No 7 New Longevity?

We defined longevity as a healthy state, free from  chronic illnesses.

The global numbers for chronic illnesses are alarming: chronic diseases are responsible for about 35 million deaths each year (United Nations, Ageing, 2017; Living Well, Dying Well, Chronic Illnesses, 2018, p. 119).

In the United States, 85% of people who are over 65 years of age suffer from one or two chronic illnesses, and nearly a quarter of children that are under 17 years old suffer one or more chronic conditions, with almost half of young to mature adults (18 to 64 years old) having one or more chronic illnesses (2018, Living Well, Dying Well, p. 120). That means that about a half of our population is constantly dealing with chronic conditions. On one hand, our life span has increased, but on the other hand, healthy longevity seems very far off the radar for people here and the world.

Did you realize that we actually have known that inflammation is a slowly debilitating killer since the late 1800s? Already in 1913, Dr. Arnold Lorand seminal work, Health and Longevity through Rational Diet, summarized the connection between inflammation and disease:

The majority of the diseases with which mankind is afflicted usually creep in through the accumulated effects of successive slight irritation, by the operation of apparently insignificant factors which are just sufficient to take part in some chemical reaction. (p. 115)

Calder et al. (2017) characterize aging as an increase in the concentration of inflammatory markers in the blood stream, a phenomenon that has been termed “inflammageing”(see Franceschi & Campisi, 2014; Franceschi et al., 2007; Franceschi et al., 2000).*

Key to longevity and anti-aging is the approach of calming inflammation, micro and macro inflammation, seen as the intrinsic biological aging clock (Luo et al., 2011). Along with inflammation, the ageing of the immune system, called immunosenescence, is an age-related decline of the immune system that leads to an increased frequency and severity of infectious diseases and certain cancers (Solana & Pawelec, 2004; Clements & Carding, 2016; Bauer & Fuente, 2014).

Immunosenescence is brought about by a continuous chronic antigenic (toxins inducing) immune response which then overloads the ability of the immune system to keep up with the demands for naïve cells, the component of cells that enable the body to fight off new, unrecognized infections or diseases (Candore et al., 2006; Calder et al., 2018).*

Once chronic inflammation is activated, it becomes a system-wide condition that leads to higher mortality rates from different illnesses (e.g., Bozzetto et al., 2018; AHA, 2017; Clements & Carding, 2016; Morrisette-Thomas et al., 2014). A study on 1018 Italian old persons demonstrated that higher levels of certain inflammation-related mediators such as IL- 6, IL-1ra ,TNA-a, TNF- a receptor II (TNFAR2) were associated with higher number of chronic illnesses, such as hypertension, diabetes, ischemic heart disease, stroke, cancer, Parkinson’s, hip fractures, joint diseases, anemia, kidney disease, and cognitive impairment (Fabbri et al., 2015).*

Longevity is a balanced state of pro- and anti-inflammatory mediators. By protecting the body against the harmful effects of inflammation with high levels of anti-inflammatory molecules, long-life with better health is attainable. For example, Le Couteur et al. (2016) explain the profound effects nutrition has on ageing and longevity, with animal studies showing longevity is achieved with a specific diet that is similar to the dietary traditions of the long-lived people on the island of Okinawa – a predominantly plant based diet.*

Many scientists have come to realize that health, longevity, and anti-aging are fundamentally dependent upon the correct nutritional strategy that facilitates and educates the body’s defense, repair, adaptation, and renewal functions (Calder et al., 2017; Mykytyn, 2005). *

In fact, scientific research insists upon the daily consumption of plant-based foods, probiotics and their fermented metabolites, plenty of fiber, and particular nutriceuticals to achieve and sustain longevity: the healthy systemic functions of the body (Seidelmann et al., 2018; Devi & Sekhar, 2018; Filosa et al, 2018; Donoiu et al., 2018; Iskar & Antonyak, 2018; Smith & Hsu, 2018; Holscher, 2017).*

The No7 Longevity is designed with what science considers the best nutritional molecules that support the body’s ability to to defend, repair, adapt and renew.

We will continue this conversation!

References

American Heart Association. (2017, March 09). Unhealthy diets linked to more than 400,000 cardiovascular deaths [AHA/ASA Newsroom]. Retrieved from Article

Bardell, D. (2018). Living with chronic illness: Better health through lifestyle medicine.  In Stevens-Long, J., Bardell, D., Living Well, Dying Well. Fielding University Press.

Bauer, M. E., & De la Fuente, M. (2014). Oxidative stress, inflammaging, and immunosenescence. In Inflammation, Advancing Age and Nutrition (pp. 39-47). https://doi.org/10.1016/B978-0-12-397803-5.00004-6

Bozzetto, L., Costabile, G., Della Pepa, G., Ciciola, P., Vetrani, C., Vitale, M., … & Annuzzi, G. (2018). Dietary fibre as a unifying remedy for the whole spectrum of obesity-associated cardiovascular risk. Nutrients, 10(7), 943. DOI:10.3390/nu10070943

Calder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Doré, J., … & Visioli, F. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing research reviews, 40, 95-119. Article

Candore, G., Colonna-Romano, G., Balistreri, C. R., Carlo, D. D., Grimaldi, M. P., Listì, F., … & Caruso, C. (2006). Biology of longevity: role of the innate immune system. Rejuvenation research, 9(1), 143-148. Abstract

Clements, S. J., & Carding, S. R. (2016). Can Nutritional Intervention Counteract Immunosenescence in the Elderly?. In Molecular Basis of Nutrition and Aging (pp. 375-391). https://doi.org/10.1016/B978-0-12-801816-3.00028-5

Donoiu, I., Militaru, C., Obleagă, O., Hunter, J. M., Neamţu, J., Biţă, A., … & Rogoveanu, O. C. (2018). Effects of Boron-Containing Compounds on Cardiovascular Disease Risk Factors–A Review. Journal of Trace Elements in Medicine and Biology. Abstract

Fabbri, E., An, Y., Zoli, M., Simonsick, E. M., Guralnik, J. M., Bandinelli, S., … & Ferrucci, L. (2014). Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 70(1), 63-70. https://doi.org/10.1093/gerona/glu127

Filosa, S., Di Meo, F., & Crispi, S. (2018). Polyphenols-gut microbiota interplay and brain neuromodulation. Neural regeneration research, 13(12), 2055. Article

Franceschi, C., & Campisi, J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 69(Suppl_1), S4-S9. Article

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., … & Cevenini, E. (2007). Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mechanisms of ageing and development, 128(1), 92-105. https://doi.org/10.1016/j.mad.2006.11.016

Franceschi, C., Bonafè, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E., & De Benedictis, G. (2000). Inflamm‐aging: an evolutionary perspective on immunosenescence. Annals of the New York Academy of Sciences, 908(1), 244-254. Abstract

Holscher, H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes, 8(2), 172-184. https://doi.org/10.1080/19490976.2017.1290756

Le Couteur, D. G., Solon-Biet, S., Wahl, D., Cogger, V. C., Willcox, B. J., Willcox, D. C., … & Simpson, S. J. (2016). New Horizons: Dietary protein, ageing and the Okinawan ratio. Age and ageing, 45(4), 443-447. Article

Lorand, A., (1013). Health and Longevity through a Rational Diet.

Luo, C., Urgard, E., Vooder, T., & Metspalu, A. (2011). The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and anti-aging. Medical hypotheses, 77(2), 174-178. https://doi.org/10.1016/j.mehy.2011.04.002

Morrisette-Thomas, V., Cohen, A. A., Fülöp, T., Riesco, É., Legault, V., Li, Q., … & Ferrucci, L. (2014). Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mechanisms of ageing and development, 139, 49-57. https://doi.org/10.1016/j.mad.2014.06.005

Mykytyn, C. E. (2006). Anti-aging medicine: A patient/practitioner movement to redefine aging. Social Science & Medicine, 62(3), 643-653. https://doi.org/10.1016/j.socscimed.2005.06.021

Seidelmann, S. B., Claggett, B., Cheng, S., Henglin, M., Shah, A., Steffen, L. M., … & Solomon, S. D. (2018). Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. The Lancet Public Health, 3(9), e419-e428. Article

Solana R. & Pawelec, G. (2004). Immunosenescence. NeuroImmune Biology, 4, 9-21.

Untied Nations, Ageing (2017),  http://www.un.org/en/sections/issues-depth/ageing/ n

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

In this fascinating website you can watch the numbers of births and the number of deaths growth in real time.  See Current World Population.  With the increasing numbers of people reaching sennescense and the mounting pandemic of chronic degenerative diseases, we need a sea-change in how we feed ourselves, to one that brings healthy longevity.

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