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Heart Health: Probiotics, Prebiotics, and Polyphenols

We have viewed research on probiotics, prebiotic and polyphenol as natural therapeutic approach for  pre-diabetes and diabetes (article in green facts) and of course this must lead us to heart health. 

Pushpass et al. (2021) recent article further examines the connection between prebiotic (fiber), probiotics, and polyphenols. 

Many of you know how dedicated Seann and I have been to formulate with the most potent and clean ingredients. Seann's love for probiotics and polyphenols is felt deeply in the Beta Glucan Synbiotic: High Potency Cardiovascular and Metabolic Support - I still remember the day we sat down with our scientists and our friends who run a huge farm to pull this formula together. 

Enjoy the article and take a look at the Beta Glucan.


Beneficial effects of probiotic, prebiotic and polyphenol-rich interventions on fasting lipid profiles have been reported, with changes in the gut microbiota composition believed to play an important role in lipid regulation. Primary bile acids, which are involved in the digestion of fats and cholesterol metabolism, can be converted by the gut microbiota to secondary bile acids, some species of which are less well reabsorbed and consequently may be excreted in the stool. This can lead to increased hepatic bile acid neo-synthesis, resulting in a net loss of circulating low-density lipoprotein. Bile acids may therefore provide a link between the gut microbiota and cardiovascular health. This narrative review presents an overview of bile acid metabolism and the role of probiotics, prebiotics and polyphenol-rich foods in modulating circulating cardiovascular disease (CVD) risk markers and bile acids. Although findings from human studies are inconsistent, there is growing evidence for associations between these dietary components and improved lipid CVD risk markers, attributed to modulation of the gut microbiota and bile acid metabolism. These include increased bile acid neo-synthesis, due to bile sequestering action, bile salt metabolising activity and effects of short-chain fatty acids generated through bacterial fermentation of fibres. Animal studies have demonstrated effects on the FXR/FGF-15 axis and hepatic genes involved in bile acid synthesis (CYP7A1) and cholesterol synthesis (SREBP and HMGR). Further human studies are needed to determine the relationship between diet and bile acid metabolism and whether circulating bile acids can be utilised as a potential CVD risk biomarker. Article



Suggested amount: 1 tablespoon



  • Pushpass, R. A. G., Alzoufairi, S., Jackson, K. G., & Lovegrove, J. A. (2021). Circulating bile acids as a link between the gut microbiota and cardiovascular health: Impact of prebiotics, probiotics and polyphenol-rich foods. Nutrition research reviews, 1-54. Article
  • Ramos, F. M. M., Salgaço, M. K., Cesar, T., & Sivieri, K. (2022). Impact of Probiotic and Prebiotic on Gut Microbiota in Pre-diabetes and Type 2 Diabetes. In Natural Products in Obesity and Diabetes (pp. 77-100). Springer, Cham. Article

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.


Green Facts:

Globe_Home 3 Polyphenols: Antimicrobial for gut Health 

Milutinović, M., Dimitrijević-Branković, S., & Rajilić-Stojanović, M. (2021). Plant extracts rich in polyphenols as potent modulators in the growth of probiotic and pathogenic intestinal microorganisms. Frontiers in Nutrition8. Article

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