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Pomegranates and Brain Cells: Protection and Regeneration

I was amazed to read this very recent scientific article that summarized all the different functions that Pomegranates fulfill in the protection, activation, regeneration, growth, and  signaling of brain cells (Aleksandrova et al., 2022).

That is a lot of work for one plant to perform, and yet this under utilized fruit (in the West) is a true hero for the brain. And we do need heroes to help protect our brain and nervous system. 

Read this abstract to see the multiple functions this great fruit performs, and realize that it is just a small fraction of its real work. Pomegranates also support heart health, atherosclerosis, diabetes, hypertension, hyperlipidemia, and some types of cancer, as well as for ulcer and diseases of the oral cavity, and so much more (Aleksandrova et al., 2022).


Pomegranate (Punica granatum L.) is a polyphenol-rich food and medicinal plant containing flavonols, anthocyanins, and tannins. Ellagitannins (ETs) are the most abundant polyphenols in pomegranate. A growing body of research shows that polyphenol-rich pomegranate extracts and their metabolites target multiple types of brain cell and support their redox balance, proliferation and survival, as well as cell signaling. Independent studies have demonstrated that the significant neuroprotective effects of ETs are mediated by their antioxidant and anti-inflammatory effects, their chelating properties, by their ability to activate various signaling pathways, as well as the ability to influence mitochondrial damage, thus regulating autophagy, apoptosis and neurotransmitter signaling. The multitude of in vitro and in vivo studies summarized in the present review suggest that pomegranate polyphenols act on both neuronal and glial cells directly, and also affect blood–brain barrier function, restoring redox balance in the blood and brain and increasing blood flow to the brain. Article

Cranberry Pomegranate Synbiotic


Allways yours,



  • Aleksandrova, S., Alexova, R., Dragomanova, S., Kalfin, R., Nicoletti, F., Fagone, P., ... & Tancheva, L. (2023). Preventive and Therapeutic Effects of Punica granatum L. Polyphenols in Neurological Conditions. International Journal of Molecular Sciences24(3), 1856. Article
  • Kandylis, P., & Kokkinomagoulos, E. (2020). Food applications and potential health benefits of pomegranate and its derivatives. Foods9(2), 122. Full-Article
  • Barati Boldaji, R., Akhlaghi, M., Sagheb, M. M., & Esmaeilinezhad, Z. (2020). Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: A randomized crossover trial. Journal of the Science of Food and Agriculture, 100(2), 846-854.
  • Sohrab, G., Roshan, H., Ebrahimof, S., Nikpayam, O., Sotoudeh, G., & Siasi, F. (2019). Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: A single-blind randomized clinical trial. Clinical nutrition ESPEN, 29, 30-35.
      Visit our Cranberry Pomegranate page to learn more, and enjoy.  
      We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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