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Endotoxemia effect on weight gain

Dear Friends

What is the correlation between processed foods, endotoxemia, and weight gain?

Cani and associates (2008) found that bacterial lipopolysaccharide (LPS) levels set the tone of insulin sensitivity and the onset of obesity and diabetes. An increased gut permeability allowed for the passage of LPS through the gut wall into the systemic circulation.  Thus, lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.

LPS are large molecules that are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals.

I’ll discuss a handy protocol below based on some exciting fiber and probiotic research.

The following diagram from Cani (2008)graphically spells out the chain of events.

Leaky Gut Cascade

 Food Science

“This graph shows that changes in the gut microbiota controls endotoximia, inflammation, and associated disorders by a mechanism that increases intestinal permeability” (Cani, 2008).

Cani (2007, 2007a, 2008, 2009) demonstrated in their research that adding to the diet soluble fibers such as inulin (containing oligofructose chains) stimulates the growth of Bifidobacteria sp. which caused a reduction in gut permeability, thereby reducing the levels of LPS systemically, and resulted in weight loss and reduced metabolic disorders.

A Therapeutic Food protocol for adding bifidobacteria and fiber (inulin) for the reduction and prevention of Obesity and Diabetes:

Pick one of these excellent sources for daily dosaging.

Direction:  Pick from any of these three products of probiotics, which contain large amounts of bifidobacteria and inulin.


  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-81.
  • Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Which country in the world has the highest percentage of obese citizens?
The Kingdom of Tonga with 68.7% obesity, and over 30% diabetes.  Their daily diet, an exceedingly high fatty corn beef, along with high starch sweet potatoes.  For snacks the Tongans love to frequently munch on lamb flap which contain 50% fat.  See Matoto et al. (2014). Burden and spectrum of disease in people with diabetes in Tonga. Public Health Action; 4: S44-S49.

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