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Chronic Urinary Tract Infections, Cranberries, & Pomegranates

Dear Friends

Urinary tract infections (UTIs) are common, however,  chronic infections can be mild to life-threatening. Antibiotic resistance and understanding that using broad-spectrum antibiotic destroys the microbiota of the host, has illuminated the need for different solutions (Klein, R.D., & Hultgren, S.J., 2020).

Bader (2017) emphasizes the growing concern of UTIs caused by antibiotic-resistant Gram-negative bacteria, such as E. coli, Salmonella, Klebeiella– all part of the family Enterobacteriaceae. Typically, UTIs have been treated with broad-specturm drugs like Fosfomycin tromethamine, amoxicillin, and others, but these drugs do not resolve UTIs very well.

There are solutions that are natural and powerful.  Proanthocyanidin from Cranberries and Pomegranates have been used for many years as anti-adhesive agents in the treatment of UTI. Gupta et al. (2012) found that an extract from cranberries actually inhibited antibiotic resistant E. coli  and prevented the adhesiveness to the walls of the bladder. In 2015 Kaspar et al. assessed the anti-adhesion effect of cranberry extract to improve urinary tract health. More recently, the research and reviews of Lima et al. (2019) and González de Llanoet al. (2019) showed new findings on the efficacy of cranberries against urinary tract infections due to the rich source of phenolic compounds.

Studies and clinical trials find Cranberries (Bader et al., 2017; Jensen et al., 2017; de Llano et al., 2015), Pomegranates (Pagliarulo et al., 2016; Heber, 2011; Duman et al., 2009), along with probiotics, prebiotics, and D- mannose (Spaulding et al., 2017; 2017a; Domenici et al., 2016), to offer effective management and support for UTI.

The advanced Cranberry Pomegranate Synbiotic formula is a marvel for UTI care.

Higher potency concentrates of organic cranberries and extracts of pomegranates are combined with BioImmersion’s renowned Super Blend of naturally occurring whole probiotic organism, expertly grown to retain their Supernatant and ORNs (oligoribonucleotides). The advanced formula is a powerhouse of goodness for urinary tract infections, and an effective agent for bladder, prostate, and kidney health.*

We standardized the Cranberry concentrate at 6%.  The 6% is refers to its amount of quinic acid, key for UTI issues.  The pomegranate is standardized at 40% with its punicalagins, offering more intensive anti-microibal, anti-oxidants, and cancer support. The probiotics work synergistically with the extracts, breaking them down into shorter phenolic molecules, which means they are bio-available to do their various tasks.


  • Bader, M. S., Loeb, M., & Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine129(2), 242-258.
  • Duman, A. D., Ozgen, M., Dayisoylu, K. S., Erbil, N., & Durgac, C. (2009). Antimicrobial activity of six pomegranate (Punica granatum L.) varieties and their relation to some of their pomological and phytonutrient characteristics. Molecules, 14(5), 1808-1817.
  • González de Llano, D., Liu, H., Khoo, C., Moreno-Arribas, M. V., & Bartolomé, B. (2019). Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria. Journal of agricultural and food chemistry67(8), 2166-2174.
  • Gupta, A., Dwivedi, M., Mahdi, A.A., Nagana Gowda, G.A., Khetrapal, C.L., Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin. Urol Res, 40(2), 143-50.
  • Heber, D., Schulman, R. N., & Seeram, N. P. (Eds.). (2006). Pomegranates: ancient roots to modern medicine. CRC press. Summary
  • Klein, R. D., & Hultgren, S. J. (2020). Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies. Nature Reviews Microbiology, 1-16.
  • Lima, M. C., de Sousa, C. P., Fernandez-Prada, C., Harel, J., Dubreuil, J. D., & de Souza, E. L. (2019). A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria. Microbial pathogenesis.
  • Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016/j.

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Transformation to healthy diets by 2050 will require substantial dietary shifts.  Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits.  (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)


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