Preventing chronically high blood sugar levels is key to reducing the risk of developing Dementia, anxiety, and depression, all of which are germinated by high blood sugar levels. Chromium as an addition to a mood disorder regiment is discussed in this article.
Neuropsychiatric disorders and type 2 diabetes (T2D) are major public health concerns proposed to be intimately connected. T2D is associated with increased risk of dementia, neuropsychiatric and mood disorders. Evidences of the involvement of insulin signaling on brain mechanisms related to depression indicate that insulin resistance, a hallmark of type 2 diabetes, could develop in the brains of depressive patients. In this article, we briefly review possible molecular mechanisms associating defective brain insulin signaling with reward system, neurogenesis, synaptic plasticity and hypothalamic-pituitary-adrenal (HPA) stress axis in depression. We further discuss the involvement of tumor necrosis factor α (TNFα) promoting defective insulin signaling and depressive-like behavior in rodent models. Finally, due to the high resistant rate of anti-depressants, novel insights into the link between insulin resistance and depression may advance the development of alternative treatments for this disease. Full-Article
Suggested use: 1 capsule daily
Chromium is well represented in scientific literature with findings on cardiovascular health, including blood sugar metabolism and weight loss support (Hua et al., 2012; Wright & Hunter, 2014; Kim, 2018; Nair, 2019).
High Active beet root offers up to 10,000ppm plant nitrate, which the body converts to nitric oxides (McDonagh et al., 2018). Beets promote nitric oxide bioavailability, which is shown in research to relax blood vessel muscles and open up circulation. Beets are reputed to be heart healthy, enhancing phase II liver enzyme (our body detoxification pathway), weight loss, and energizing the body with more oxygen (Hobbs et al., 2012; Beals et al., 2017; Krajka-Kuźniak et al., 2013; Clifford et al., 2015).
Seann and Dohrea
- Lyra e Silva, N. D. M., Lam, M. P., Soares, C. N., Munoz, D. P., Milev, R., & De Felice, F. G. (2019). Insulin resistance as a shared pathogenic mechanism between depression and type 2 diabetes. Frontiers in psychiatry, 10, 57.
- Brownley, K. A., Boettiger, C. A., Young, L., & Cefalu, W. T. (2015). Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating. Medical hypotheses, 85(1), 45-48.
- Beals, J.W., Binns, S.E., Davis, J.L., Giordano, G.R., Klochak, A.L., Paris, H.L. … Bell, C. (2017). Concurrent Beet Juice and Carbohydrate Ingestion: Influence on Glucose Tolerance in Obese and Nonobese Adults. J Nutr Metab, 2017:6436783. Article
- Clifford, T., Howatson, G., West, D.J., & Stevenson, E.J. (2015). The potential benefits of red beetroot supplementation in health and disease. Nutrients, 7(4), 2801-22. Article
- Hua, Y., Clark, S., Ren, J., & Sreejayan, N. (2012). Molecular mechanisms of chromium in alleviating insulin resistance. The Journal of Nutritional Biochemistry, 23(4), 313-319. Article
- Krajka-Kuźniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., & Baer-Dubowska, W. (2012). Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. Food and chemical toxicology, 50(6), 2027-2033. Article
- McDonagh, S. T., Wylie, L. J., Thompson, C., Vanhatalo, A., & Jones, A. M. (2019). Potential benefits of dietary nitrate ingestion in healthy and clinical populations: A brief review. European journal of sport science, 19(1), 15-29. Article
- Nair, S. (2019). Metabolic effects of chromium—Potential molecular mechanisms. In The Nutritional Biochemistry of Chromium (III) (pp. 175-191). Elsevier. Abstract
- Wright, N.J.D., Hunter, T. (2014). Evidence for use of chromium in treatement of pre-diabetes. Journal of Pharmaceutical and Scientific Innovation, p. 298-305. Article
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
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