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Brain / Gut Axis: Autism and Elevated Mood

Research ascribes various etiologies to Autism Spectrum Disorder (ASD), and a few solutions.

Exogenous factors such as iatrogenic drugs, pollutants of various kinds, and overuse of antibiotics; and endogenous factors such as dysbiosis of the GI Tract, mitochondrial dysfunction, and of course genetics - are contributing elements to ASD.

It is important to keep in mind that genetic causation is found to be in the low percentile, whereas dysbiosis and mitochondrial dysfunction do present major links to ASD. 

Let’s start with dysbiosis. Overgrowth of clostridia, bacteriodes, and desulfovibrio are all ASD-associated bacterial populations. The overuse of antibiotics enables the clostridial family of bacteria to dominate because their spore forming ability resist many antibiotics and they can easily gain a foothold over good bacteria.

Clostridia is a big producer of the SCFA propionate. Too much propionate in the systemic circulation (which is able to cross the blood-brain barrier) becomes neurological and mitochondrial toxins, disrupting and causing the very symptoms that we see with ASD patients.

There is strong support in the literature for foundational probiotic organisms that reduce the overload of clostridium: The exact organisms we have chosen for our probiotics.

Research is showing that L. plantarum, L. casei rhamnosus, B. longum and L. acidophilus can put out bacterocins against clostridia. Doctors who have used our Original Synbiotic and our Supernatant Synbiotic (either one works), found improvement in the behaviors of ASD patients.

I suggest the following dosage:

Original Synbiotic: up to 1 tsp. daily. With very young patients start with an eight of a tsp and work up slowly adjusting the dosage. Back off just a little from a dosage that causes reaction. You be able to get up to a tsp dose in about a month of gradually building it up.

Original Synbiotic 


  • Frye, R. E., Rose, S., Slattery, J., & MacFabe, D. F. (2015). Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microbial ecology in health and disease, 26(1), 27458.
  • MacFabe, D. F. (2015). Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders. Microbial ecology in health and disease, 26(1), 28177.
  • MacFabe, D. F. (2012). Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microbial ecology in health and disease, 23(1), 19260.
  • Wang, H., Lee, I. S., Braun, C., & Enck, P. (2016). Effect of probiotics on central nervous system functions in animals and humans: a systematic review. Journal of neurogastroenterology and motility, 22(4), 589.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

My Research: Peace - "I and Thou"

Globe_Home 3I continue to remind you of Buber's "I and Thou" for Mother's day. Our world needs women to balance and bring equilibrium.  Peace happens when we become conscious of our divisions, of hatred, of wars that are always unnecessary, and our great need to evolve toward friendships, understanding, compassion, nurture, and love. 

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