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Beta Glucan: The Heart – Gut Connection

Dear Friends                                                                                                                                                                                                            Beta Glucan Photo jpeg 2

We are proud to have the Beta Glucan High Potency Synbiotic qualify for the American Heart Association and the FDA “Heart Healthy” seal of approval: improving lipid serum levels.*

The special heat-shearing technology used to liberate the beta-glucans from the oat is patented (US Patent # 6,060,519), and considered by the FDA as a gluten free ingredient (99.98% gluten free).*

The food ingredients in the Beta Glucan formula are chosen carefully for their highest phytonutrient potential. The proprietary mix contains: Organic matrix USDA patented hydrocolloidal beta glucan oat bran (75%), organic whole red beetroot (15%), and organic inulin from chicory fiber (10%).  Advances in microbiome research and technology allow us to grow our hardy and viable pedigreed Original probiotic strains. Our high potency Original probiotics, along with the B-Glucans, Beetroot, and Inulin offer heart healthy properties, GI support with plant fibers and probiotics, weight-management, regularity, and a boost in energy.*

Oats and oat beta glucan have enjoyed a rich cultural historicity and extensive research on heart health  (Andersson & Hellstrand, 2012). From Shaper & Jones (1959) analysis of healthy dietary habits, to the Cornell China study in 1998, and the NIH report in 2015, dietary fibers, whole plant-based foods, and exercise are shown to be essential for a healthy heart. Oats and oat beta glucan are found to reduce serum LDL cholesterol (Ho et al., 2016; Zhu et al., 2015; Whitehead et al., 2014; Wolever et al., 2010), improve liver function (Chang et al., 2013), and promote bowel regularity (Clemens, 2012; Mobley et al., 2014).*

Red beetroot offer a rich source of phyto-nutrients, including ascorbic acid (vitamin C), carotenoids, phenolic acids, and flavonoids. Beets provide a source of dietary nitrate, shown in research to have important implication for heart health (Kapil et al., 2014). Beet’s nutrients are found to prevent oxidation of LDLs, lower triglycerides, and balance blood pressure (Clifford et al., 2015; Eggenbeen et al., 2016; Hobbs et al., 2013). As a multifunctional food, beets also stimulate Phase II liver detox (Vulić et al., 2014), as well as perform a host of other health benefits, including the production of energy for exercise (Murphy et al., 2012), promotion of joint health (Pietrzkowski et al., 2010), Antioxidant (Georgiev et al., 2010), and support for individuals who undergo oncological treatments (Kapadia et al., 2013, 2011; Das et al., 2013).*

The Beta Glucan formula is comprised of our Original probiotics proprietary blend: L. acidophilus, B. longum, L. rhamnosus, L. plantarum, S. thermophilus. Our Original strains of lactic acid bacteria are pedigreed and certified, based on ATCC prototypical strains and confirmed routinely by 16sRNA sequencing to provide highest quality probiotic material. Our strains are hardy, strong, and effective.*

The Original strains are mixed into a proprietary blend of 33 billion cfu/tbl, plus a bonus of 50 billion more probiotic organism added at the time of manufacturing to boost and ensure a high potency. If taken only as a probiotic formula, 1-2 teaspoons will provide a daily dosage of up to 25 billion cfu.

Probiotics are found in research to positively support heart health (Kassaian et al., 2017; Sáez-Lara et al., 2016; DiRienzo, 2014; Delzenne et al., 2011; Saini et al., 2010), with many researchers positing the connection between heart and gut health (Serino et al., 2014; Huang et al., 2013). The Beta Glucan was formulated to nourish both heart and gut into health.*

Inulin from organic chicory root supplies food for probiotic organisms. Probiotic organisms need soluble fiber like inulin to grow and multiply. See Slavin (2013) on fiber as prebiotics, and Dehghan et al. (2013) on inulin and cardiovascular support.*

Together with probiotic, inulin is also found in research to help tighten cell junctions, which is thought to aid against leaky gut syndrome (Cani et al., 2007, 2007a, 2008, 2009).*

The Beta Glucan formula is utilized for bowel regulation. Plant and oat fibers are shown to increase bowel regularity (Schmier et al., 2014).*

The Beta Glucan is multifunctional due to its oat beta glucans, red beetroot, inulin from chicory, and strong probiotic organism. Each ingredient is shown in research to offer heart healthy food, boost energy, and support the GI tract, liver and kidneys, promoting regularity and GI comfort.

Take a look at the references below to engage in learning more about the many health applications scientists have discovered over the years. These shows a fraction of the research findings on oat beta glucan, probiotics, red beetroot, and inulin.*

*These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, treat, cure or prevent any disease. The information and citations of research are for informational purposes only. Please be sure to consult your health care provider before taking this or any other product.


  • Anderson, K.E., & Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways. Mol Nutr Food Res, 56(7), 1003-13. DOI:10.1002/mnfr.201100706
  • Cani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut, 58(8), 1091-1103. DOI:10.1136/gut.2008.165886
  • Cani, P.D., Bibiloni, R., Knauf, C., waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice. Diabetes, 57, 1470-8. DOI:10.2337/db07-1403
  • Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D. … Burelini, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56, 1761-72. DOI:10.2337/db06-1491
  • Cani, P.D., Neyrinck, A.M., Fava, F., Knauf, C., Burcelin, R.G., Tuohy, K.M. … Delzenne, N.M. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia, 50, 2374-83. DOI:10.1007/s00125-007-0791-0
  • Chang, H.C., Huang, C.N., Yeh, D.M., Wang, S.J., Peng, C.H., & Wang, C.J. (2013). Oat prevents obesity and abdominal fat distribution, and improves liver function in human. Plant Foods Hum Nutr, 68(1), 18-23. DOI:10.1007/s11130-013-0336-2
  • Clemens, R., Kranz, S., Mobley, A.R., Nicklas, T.A., Raimondi, M.P., Rodriguez, J.C., … Warshaw, H. (2012). Filling American’s fiber intake gap: Summary of roundtable to probe realistic solutions with a focus on grain-based foods. J Nutr, 142(7), 1390-1401. DOI:10.3945/jn.112.160176
  • Clifford T, Howatson G, West DJ, Stevenson EJ. (2017). Beetroot Juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. DOI:10.1139/apnm-2017-0238
  • Clifford, T., Howatson, G., West, D.J., Stevenson, E.J. (2015). The potential benefits of red beetroot supplementation in health and disease. Nutrients,7(4):2801-22. DOI: 10.3390/nu7042801
  • Das, S., Fillippone, S.M., Williams, D.S., Das, A., Kukreja, R.C. (2016). Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. Mol Cell Biochem, 421(1-2), 89-101.
    DOI: 10.1007/s11010-016-2789-8
  • Das, S., Williams, D.S., Das, A., Kukreja, R.C. (2013). Beet root juice promotes apoptosis in oncogenic MDA-MB-231 cells while protecting cardiomyocytes under doxorubicin treatment. J. Exp. Second. Sci, 2, 1–6. Abstract
  • Dehghan, P., Pourghassem, G.B, & Asgharijafarabadi, M. (2013). Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial. Health Promot Perspect, 3(1), 55-63. DOI:10.5681/hpp.2013.007
  • Delzenne, N.M., Neyrinck, A.M., Cani, P.D. (2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact, 10 Suppl 1, S10. DOI: 10.1186/1475-2859-10-S1-S10
  • DiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets. Nutr Rev, 72(1), 18-29. DOI:10.1111/nure.12084
  • Domínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MC, Herreros PV, Garnacho-Castaño MV. (2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients, 9(1). DOI:10.1016/j.jand.2011.12.002
  • Eggenbeen, J., Kim-Shapiro, D.B., Haykowsky, M., Morgan, T.M., Basu, S., Brubaker, P., … Kitzman, D.W. (2016). One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. JACC Heart Fail, 4(6), 428-37. DOI: 10.1016/j.jchf.2015.12.013
  • Georgiev, V.G., Weber, J., Kneschke, E.M., Denev, P.N., Bley, T., Pavlov, A.I. (2010). Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit dark red.  Plant Foods Hum Nutr, 65(2):105-11. DOI:10.1007/s11130-010-0156-6
  • Ho, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 116(8):1369-1382. DOI: 10.1017/S000711451600341X
  • Hobbs, D.A., George, T.W., Lovegrove, J.A. (2013). The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutr Res Rev, 26(2), 210-22. DOI:10.1017/S0954422413000188
  • Huang, Y., Wang, X., Wang, J., Wu, F., Sui, Y., Yang, L., Wang, Z. (2013). Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci, 96(5), 2746-53. DOI:10.3168/jds.2012-6123
  • Kapadia, G.J., Rao, G.S., Ramachandran, C., Iida, A., Suzuki, N., & Tokuda, H. (2013). Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med., 1. DOI:10.1515/jcim-2013-0007
  • Kapadia, G.J., Azuine, M.A., Rao, G.S, Arai, T., Lida, A., & Tokuda, H. (2011), Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. Anticancer Agents Med Chem, 11(3), 280-4. Abstract
  • Kapil, V., Weitzberg, E., Lundberg, J.O., Ahluwalia, A. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. Nitric Oxide, 38, 45-57. DOI:10.1016/j.niox.2014.03.162
  • Kassaian, N., Aminorroaya, A., Feizi, A., Jafari, P., Amini, M. (2017). The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial. Trial, 18(1), 148. DOI:  10.1186/s13063-017-1885-8
  • Mobley, A.R., Jones, J.M., Rodriguez, J., Slavin, J., & Zelman, K.M. (2014). Identifying practical solutions to meet American’s fiber needs: Proceedings from the Food & Fiber Summit. Nutrients, 8(7), 2540-51. DOI:10.3390/nu6072540
  • Murphy, M., Eliot, K., Heuertz, R.M., Weiss, E. (2012). Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet, 112(4), 548-52. DOI: 10.1016/j.jand.2011.12.002
  • Sáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A. (2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci, 17(6). DOI:10.3390/ijms17060928
  • Saini, R., Saini, S., & Sharma, S. (2010). Potential of probiotics in controlling cardiovascular diseases. J. Cardiovasc Dis Res,1(4), 213-214. DOI:  10.4103/0975-3583.74267
  • Schmier, J.K., Miller, P.E., Levine, J.A., Perez, V., Maki, K.C., Rains, T.M., … Alexander, D.D. (2014). Cost savings reduced constipation rates attributed to increased dietary fiber intakes: A decision-analytic model. BMC Public Health, 14-374. DOI: 10.1186/1471-2458-14-374
  • Serino, M., Blasco-Baque, V., Nicolas, S., & Burcelin, R. (2014). Far from the Eyes, Close to the Heart:  Dysbiosis of Gut Microbiota and Cardiovasuclar Consequences. Curr Cardiol Rep, 16(11), 540. DOI:10.1007/s11886-014-0540-1
  • Shaper, A.G., & Jones, K.W. (1959). Serum-cholesterol, diet, and coronary heart disease in Africans, and Asians in Uganda. The Lancet, 275(7102), 534-37. DOI: 10.1093/ije/dys137
  • Slavin, J. (2013). Fiber and prebiotics: mechanism and health benefits. Nutrients, 5(4), 1417-1435. DOI:10.3390/nu5041417
  • Vulić J.J., Ćebović T.N., Čanadanović-Brunet J.M., Ćetković G.S., Čanadanović V.M., Djilas S.M., Tumbas Šaponjac V.T. In vivo and in vitro antioxidant effects of beetroot pomace extracts. J. Funct. Foods. 2014;6:168–175.
  • Whitehead A, Beck EJ, Tosh S, Wolever TM. (2014). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 100(6), 1413-21. DOI:10.3945/ajcn.114.086108
  • Wolever TM, Tosh SM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Thomson BA, Duss R, Wood PJ  (2010). Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am J Clin Nutr, 92(4):723-32. DOI: 10.3945/ajcn.2010.29174
  • Zhu, X., Sun, X., Wang, M., Zhang, C., Cao, Y., Mo, G., Liang, J., Zhu, S.  (2015). Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis, 25(8), 714-23. DOI:10.1016/j.numecd.2015.04.008

Article by Dohrea Bardell, PhD.

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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