Alzheimer's disease: Application of Brown Seaweed

Dear Friend,

6 million people are afflicted with neurogenerative diseases such as Alzheimer’s or Parkinson’s and the numbers are rising (Alghazwi et al., 2020).

Oxidative stress and inflammation are thought to be the leading factors in the progression of Alzheimer’s. A recent 2020 study concludes that the onset of Alzheimer’s disease, Parkinson’s and other neurodegenerative diseases are partly due to a “vicious cycle of mitochondria” that destroy brain cells (Elfawy & Das, 2019) . Mitochondria are energy producing organelles that control our body’s cell survival and produces the energy molecule ATP. However, when the mitochondria produce excess of ‘reactive oxygen species' or ROS, a vicious cycle begins which causes the brain tissue to suffer oxidative stress. Scientists believe that since the brain cannot regulate itself like other organs, this accumulation of ROS damages mDNA which then leads to more excess of ROS and more damage to brain cells.

Brown seaweed contain high amount of sulfate polysaccharides which have been shown to exhibit high anti-inflammatory and antioxidant activities in the brain, as well as excellent scavengers of free radicals. In fact, compromised brain cells (from ROS) are revived by 40% when treated with brown seaweed's sulfated polysaccharides  (Bauer et al., 2020)

Abstract 

Neurodegenerative diseases are among the most widespread diseases affecting humans, and the number of patients is only rising. Seaweed polysaccharide extracts show significant neuroprotective and reparative activities. Seaweed polysaccharides might provide the next big breakthrough in neurodegenerative disease treatment. This paper reviews the applications of seaweed polysaccharides as potential treatments of neurodegenerative diseases. The particular focus is on fucoidan, ulvan, and their derivatives as potential agents to treat Alzheimer’s disease. This review provides a critical update on the progress in this important research area. Article

Weight-Less: Brown Seaweed extracts and 7 Keto.  Suggested use: 1-2 capsules, 20 minutes before meals.

Sincerely yours,

Seann

References

• Bauer, S., Jin, W., Zhang, F., & Linhardt, R. J. (2021). The application of seaweed polysaccharides and their derived products with potential for the treatment of Alzheimer’s disease. Marine Drugs, 19(2), 89. Article
• Alghazwi, M., Charoensiddhi, S., Smid, S., & Zhang, W. (2020). Impact of Ecklonia radiata extracts on the neuroprotective activities against amyloid beta (Aβ1-42) toxicity and aggregation. Journal of Functional Foods, 68, 103893.
• Elfawy, H. A., & Das, B. (2019). Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies. Life sciences, 218, 165-184.

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