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2022 Research: Prebiotic, Probiotic and Synbiotic are Effective for IBD

How does a good probiotic formula help Inflammatory Bowel Disease (IBD)? 

This is exactly what the research team of Wong et al. (2022) wanted to find out. In a beautifully detailed article, the team explains step by step how they worked with mice to decipher whether a robust formula of Prebiotics (fructo-oligosaccharide), Probiotic (four foundational organisms), and Synbiotic (combination of pre and pro biotics) help to reduce acute colitis. 

Because of the correlation between cytokine levels, intestinal integrity and IBD, the team's conclusion is that prebiotic, probiotic and symbiotic strengthened the intestinal integrity and suppressed pro-inflammatory cytokines levels IL6/ and STAT3 signaling, reducing and ameliorating acute colitis (Wong et al., 2022). 

What is the best combination? The synbiotic which has both the prebiotic fiber and the probiotics was most effective. 


In inflammatory bowel disease (IBD), an altered gut microbiota is observed and is a proposed causal factor for compromised intestinal integrity and disease progression. Therefore, maintenance and modulation of the gut microbiome may be beneficial to health and for treatment of IBD. Prebiotics, probiotics, and synbiotics have been suggested to positively impact the gut microbiota and thus we aimed to evaluate the effects of a formulated prebiotic mixture (Pre), probiotic mixture (Pro), and synbiotics (Syn) in normal mice, and their therapeutic effects in acute dextran sulfate sodium (DSS)-induced mice. We observed significant reductions in plasma IL-6 levels and increased intestinal occludin expression in both models after treatment. In DSS-induced mice, treatment modulated gut microbiota, improved gut integrity, upregulated anti-inflammatory cytokines, and suppressed plasma pro-inflammatory mediators, potentially via inhibition of IL-6/STAT3 signaling. Our results demonstrate the beneficial effects of Pre, Pro, and Syn consumption and their potential therapeutic effects in IBD. Article


Original Synbiotic 

Original Synbiotic 

 Suggested use: One teaspoon by mouth (very tasty) or mixed in a little water. 


  • Wong, W. Y., Chan, B. D., Leung, T. W., Chen, M., & Tai, W. C. S. (2022). Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice. Journal of Functional Foods88, 104871. Article

Sincerely yours,

Dohrea and Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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And more on Probiotics and IBD:

Zhang, X. F., Guan, X. X., Tang, Y. J., Sun, J. F., Wang, X. K., Wang, W. D., & Fan, J. M. (2021). Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in inflammatory bowel disease: A systematic review and meta-analysis. European journal of nutrition, 1-21. Abstract 

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