Origin of the Human Proteome
Dear Friends Over the past two weeks, within our Forward Thinking newsletters, we have begun to the roll out the exciting news regarding the bugs that live in us and on us (our human microbiome) and their influence over our state of health or disease. Two weeks ago we defined the human microbiome, and last week we began to look at some of the conclusions derived from the five years of research on the human microbiome just concluded by the Human Microbiome Project consortium (HMP). Exposing my 60’s roots, I used the phase mind-blowing to describe some of the statements coming forth from the HMP scientists regarding their findings. We humans are mostly microbes (Greenblum S. et al. Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease Proc Natl Acad Sci USA 2012 January 10; 109(2):592-599). I’ll bet, if you’ve ever focused on the question, who am I or what am I, your answer was never a collection of human cells and microbial cells. But my friends, that is exactly what the elite HMP scientists are saying that we in fact are. There are 6 major sites on and in our bodies—the gastrointestinal tract, skin, nasal, oral, airways and urogenital—where microbes have intimate contact with our human cell. The microbial genes produce proteins that interact with the proteins produced by our human cells, thereby jointly providing the protein building blocks for our body’s physiological metabolic pathways, for messenger molecules, receptor sites, neurotransmitters, hormones, enzymes, etc. Our digestive system, our nervous systems, our immune system, all body systems for that matter depend on the proteins produced by a healthy microbiome. For example, what is most interesting to consider is that the microbiome of our gastrointestinal tract produces three times more unique proteins than do our human cells. How this mix of proteins combine together to make for a healthy functioning body is the intense focus of the HMP—the study of the proteome. The proteome being defined as the entire complement of proteins in a given area. Proteomics, the science of proteins, is very much part of the leading edge for medical research today. Next week we focus on a paper by Cho and Blaser entitled, The Human Microbiome: at the interface of health and disease. One of the key thoughts coming from their paper is redundancy rules. Stay tuned. Clinical Note:
The BioImmersion Synbiotic Formulas are the Original Synbiotic formula, the Beta-Glucan Synbiotic Formula, the Triple Berry Probiotic Formula, the High ORAC Synbiotic Formula, the Supernatant Synbiotic Formula, the Cranberry Pomegranate Synbiotic Formula and the No. 7 Systemic Booster.They represent the following strains: L. bulgaricus ATCC pending, DUP 14073, L. helveticus ATCC 7994, L. casei ATCC 393, B. infantis ATCC 15697, B. longum ATCC 15707, L. acidophillus ATCC 4356, S. thermophillus ATCC 19258, L. plantarum ATCC 8014 and L. rhamnosus ATCC 7469.
We will be driving into the research on the different strains, relative to human health. The Last Quiz Answer: This amazing creature is a Giant African Bullfrog, Pyxicephalus adspersus, always ready for its next meal. And, they will eat just about anything—spiders, rodents, birds, snakes, other frogs—anything they can get their huge mouth around. Plus they have teeth-like projections called odontoids, that feel like broken glass. They are found throughout southern, central and eastern Africa, and are the worlds second largest frog species, reaching a weight of five pounds and a length of almost a foot. They can jump 12 feet.
The last two weeks in Green Facts we’ve been focusing on our global climate crisis. It is very clear that if we continue on in our current course of trashing our planet we will in the immediate future be facing our planet’s Sixth Mass Extinction. We must take strong action now!The following video takes us to the core of our problem and solicits the power of the big guns, bringing in the biosphere itself to make the necessary corrections to save us. Enjoy this brilliant presentation: Most Powerful Geologic Force. (Scroll down towards the bottom of this linked page to find the presentation) ©2005 – 2012 BioImmersion Inc. All Rights Reserved
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