Sulforaphane Reduces Skin Injury from Radiation
Radiation therapy creates both short and long-term side effects to healthy skin tissue. The damage to skin is caused both by the radiation therapy and the body's own defense mechanism that causes inflammation.
The central research question Wei et al. asked is whether Sulforaphane can help reduce skin injury caused by radiation therapy.
This 2021 research by Wei et al. was conducted in a lab with four groups of mice: one for control, second group received radiation, third group received radiation plus Sulforaphane, fourth group received Sulforaphane alone. The Sulforaphane was from broccoli extract.
Again, I do need to mention that the mice were treated well although to be honest, it is difficult to read in detail the whole process as there is suffering involved.
The results of the research show that the Sulforaphane from broccoli extract did inhibit skin injuries and inflammation from radiation.
This article mainly observed the protective effect of sulforaphane (SFN) on radiation-induced skin injury (RISI). In addition, we will discuss the mechanism of SFN’s protection on RISI. The RISI model was established by the irradiation of the left thigh under intravenous anesthesia. Thirty-two C57/BL6 mice were randomly divided into control group (CON), SFN group, irradiation (IR) group, and IR plus SFN (IR/SFN) group. At eight weeks after irradiation, the morphological changes of mouse skin tissues were detected by H&E staining. Then, the oxidative stress and inflammatory response indexes in mouse skin tissues, as well as the expression of Nrf2 and its downstream antioxidant genes, were evaluated by ELISA, real-time PCR, and Western blotting. The H&E staining showed the hyperplasia of fibrous tissue in the mouse dermis and hypodermis of the IR group. Western blotting and ELISA results showed that the inflammasome of NLRP3, caspase-1, and IL-1β, as well as oxidative stress damage indicators ROS, 4-HNE, and 3-NT, in the skin tissues of mice in the IR group were significantly higher than those in the control group (p< 0.05). However, the above pathological changes declined sharply after SFN treatment (p < 0.05). In addition, the expressions of Nrf2 and its regulated antioxidant enzymes, including CAT and HO-1, were higher in the skin tissues of SFN and IR/SFN groups, but lower in the control and IR groups (p < 0.05). SFN may be able to suppress the oxidative stress by upregulating the expression and function of Nrf2, and subsequently inhibiting the activation of NLRP3 inflammasome and DNA damage, so as to prevent and alleviate the RISI. Article
Glucosinolates & Sulforaphanes
Each of our vegan capsule has 500 mg of organic broccoli sprouts, harvested at the peak of their phytonutrient power.
Suggested dose: 1-2 capsules a day, preferably before going to sleep.
Wei, J., Zhao, Q., Zhang, Y., Shi, W., Wang, H., Zheng, Z., ... & Jiang, X. (2021). Sulforaphane-Mediated Nrf2 Activation Prevents Radiation-Induced Skin Injury through Inhibiting the Oxidative-Stress-Activated DNA Damage and NLRP3 Inflammasome. Antioxidants, 10(11), 1850. Article
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And more on broccoli sprouts:
Du, P., Zhang, W., Cui, H., He, W., Lu, S., Jia, S., & Zhao, M. (2022). Sulforaphane Ameliorates the Severity of Psoriasis and SLE by Modulating Effector Cells and Reducing Oxidative Stress. Frontiers in pharmacology, 13, 805508-805508. Article
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