Together, let’s put an end to deteriorating health

The Centrality of Mitochondrial Dysfunction in Autism Spectrum Disorders

We have been discussing the importance of a healthy ATP production, nourishing the body with the correct nutrients to create more energy in every cell. 

We also discussed the gut - brain axis in children with autism spectrum disorders (ASD), and how probiotics and prebiotic shifts the population toward a healthy homeostasis, to calm, strengthen, and protect the inflamed gut, and in turn, help the brain to function better. 

ATP production has been studied as a possible pathway toward health for children with ASD. And in fact, mitochondrial dysfunction is now considered central to the development of ASD, as it affects the function of every cell.

Some studies are even finding issues with mitochondrial metabolism in mothers which they then pass on to the child, however, as in all things scientific, this needs to be examined more thoroughly (Frye et al., 2024).

Mitochondrial Dysfunction has been researched for quite some time (see Rossignol et al., 2012) and since there is a great heterogeneity of the ASD population, it is difficult to ascertain therapeutic modalities. 

Frye et al. (2024) is a worthy Article, learning exactly what are the metabolic  biomarkers and the immense research that each of these biomarkers has is impressive. 

From ATP, to Pyruvate, Lactate (and lactate-to-pyruvate ratio), Alanine (and alanine-to-lysine ratio), carnitine, Acyl-carnitines, Coenzyme Q10, Tricarboxylic Acid (TCA), Ammonia, Creatine kinase - and the list goes on, including generic biomarkers. 

The research teams also covers environmental exposures, and finally treatment, including supplements and diets. 

A worthy article, although incredibly long, but filled with research and suggestions for therapy. 

I will highlight here our Energy which helps to boost ATP production and No 7 for the gut and brain axis. 

Energy

Yours as always,

Dohrea 

References

  • Frye, R. E., Rincon, N., McCarty, P. J., Brister, D., Scheck, A. C., & Rossignol, D. A. (2024). Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis. Neurobiology of Disease, 106520. Article
  • Legido, A., Jethva, R., & Goldenthal, M. J. (2013, September). Mitochondrial dysfunction in autism. In Seminars in pediatric neurology (Vol. 20, No. 3, pp. 163-175). WB Saunders. https://www.sciencedirect.com/science/article/abs/pii/S1071909113000624
  •  Rossignol, D. A., & Frye, R. E. (2012). Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Molecular psychiatry17(3), 290-314. https://www.nature.com/articles/mp2010136

 

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.  

World Peace: Nobel Peace Prize 

Globe_Home 3A Japanese anti-nuclear weapons advocacy group—made up of atomic bomb survivors from Hiroshima and Nagasaki—was awarded the 2024 Nobel Peace Prize yesterday, capping off a week of recognitions in physics, literature, and more. The group is the first Japanese recipient since 1974 to receive the Peace Prize. (1440 Daily Digest, Oct. 12, 2024)

©2005 - 2024 BioImmersion Inc. All Rights Reserved

 

Net Orders Checkout

Item Price Qty Total
Subtotal $0.00
Shipping
Total

Shipping Address

Shipping Methods