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Psychobiotics for Young Children and Adolescents

How can probiotics positively effect our young ones and adolescents? This is  Bassso et al. (2022) systematic review of articles on probiotics and prebiotics use for children age 6 onward to the age of 25. 

But the review starts with 2,618 articles and eliminates all except 16 articles. Now that raised a red flag. Checking further who the authors are and who contributed funds to the researchers (something that all good research scientists should do), it turns out that 2 out of the five researchers come from the multinational dairy conglomerate, FrieslandCampina, that is worth 5.6 billion euros. A dairy company in competition with probiotics? 

The most interesting part of the article is their inability to dismiss the importance of probiotics and prebiotics for children as their brain is dependent on good nutrients and healthy gut.

There is just too much solid research to support the use of probiotics and the importance of fiber as prebiotics for a robust growth of the microbiota for children and young adults.

 We will take a look at another 2022 systematic review on Monday - a more straightforward analysis of Psychobiotics.



This systematic review brings together human psychobiotic interventions in children and adolescents (aged 6–25 years) to evaluate the efficacy of pre- and probiotic supplements on stress, anxiety, and cognitive outcomes. Psychobiotic interventions in animal studies highlighted sensitivity to effects during development and maturation in multiple domains from emotion to cognitive processing. Several translational psychobiotic interventions in humans have been carried out to assess effects on emotion and cognition during childhood and into adulthood. The findings illustrate that there are limited consistent psychobiotic effects in developing human populations, and this is proposed to be due to heterogeneity in the trials conducted. Consequentially, it is recommended that three specific factors are considered in future psychobiotic trials: (1) Specificity of population studied (e.g., patients, developmental age), (2) specificity of intervention, and (3) homogeneity in outcome measures. Article

Original Synbiotic 


Original Synbiotic 

 Suggested use: One teaspoon by mouth (very tasty) or mixed in a little water. 




  • Basso, M., Johnstone, N., Knytl, P., Nauta, A., Groeneveld, A., & Cohen Kadosh, K. (2022). A Systematic Review of Psychobiotic Interventions in Children and Adolescents to Enhance Cognitive Functioning and Emotional Behavior. Nutrients14(3), 614. Article

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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 And a peek at next week:


Zhu, H., Tian, P., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2022). A psychobiotic approach to the treatment of depression: A systematic review and meta-analysis. Journal of Functional Foods, 91, 104999.  Article


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