Elevating the mood of women who suffer from the beginning stages of postpartum blues so they do not slide into a full blown postpartum depression is the focus of this study by Dowlati's team of researchers (2017).
The specific supplement used on one group of women has Blueberry extract, blueberry juice, plus 2g of tryptophan and 10g of tyrosine.
During the peak of postpartum blues, day five, there is a drastic drop of estrogen (several hundred-fold!) and progesterone, there is also neurobiological change in the brain with higher levels of monoamine oxides A (MAO-A) which may explain the decline of estrogen.
The study is trying to stop this elevation of MAO-A and through this the hope is to Stop the progression a typical postpartum blues into a debilitating postpartum depression.
The combination of ingredients has worked amazingly well in this study.
Medical research is moving toward prevention strategies during prodromal states. Postpartum blues (PPB) is often a prodromal state for postpartum depression (PPD), with severe PPB strongly associated with an elevated risk for PPD. The most common complication of childbearing, PPD has a prevalence of 13%, but there are no widespread prevention strategies, and no nutraceutical interventions have been developed. To counter the effects of the 40% increase in monoamine oxidase A (MAO-A) levels that occurs during PPB, a dietary supplement kit consisting of monoamine precursor amino acids and dietary antioxidants was created. Key ingredients (tryptophan and tyrosine) were shown not to affect their total concentration in breast milk. The aim of this open-label study was to assess whether this dietary supplement reduces vulnerability to depressed mood at postpartum day 5, the typical peak of PPB. Forty-one healthy women completed all study procedures. One group (n = 21) received the dietary supplement, composed of 2 g of tryptophan, 10 g of tyrosine, and blueberry juice with blue- berry extract. The control group (n = 20) did not receive any supplement. PPB severity was quantitated by the elevation in depressed mood on a visual analog scale following the sad mood induction procedure (MIP). Following the MIP, there was a robust induction of depressed mood in the control group, but no effect in the supplement group [43.85 ± 18.98 mm vs. 0.05 ± 9.57 mm shift; effect size: 2.9; F(1,39) = 88.33, P < 0.001]. This dietary supplement designed to counter functions of elevated MAO-A activity eliminates vulnerability to depressed mood during the peak of PPB. Article
suggested amount: 1 capsule of Blueberry Extract daily.
Dowlati, Y., Ravindran, A. V., Segal, Z. V., Stewart, D. E., Steiner, M., & Meyer, J. H. (2017). Selective dietary supplementation in early postpartum is associated with high resilience against depressed mood. Proceedings of the National Academy of Sciences, 114(13), 3509-3514. Article
PS - check out our Blueberry Extract
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
And blueberries also improve cognition in older adults:
Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt-Hale, B. (2018). Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European journal of nutrition, 57(3), 1169-1180.
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