It is well known that garlic and onion possess anti-viral properties. Based on this, the researchers of Pandey et al. (2021) established an in silico approach (computer simulation) to establish the inhibition potential of 23 compounds of garlic and onion.
In their study, Lipinski’s rule of five was used to compare and calculate the phyto compounds in garlic and onion and their different drug-likeness parameters, assessing certain pharmacological properties that would help to make them a possible “drug candidate” for humans. The results showed that selected compounds of Allium sativum (garlic) and Allium cepa (onion) are in accordance with the drug-likeness properties of Lipinski’s rule of five (see Table 3 and 4 in the article). What does that mean to you? Garlic and onions are robust foods and when used therapeutically have many incredible health benefits. Article
The infection of the global COVID-19 pandemic and the absence of any possible treatment options warrants the use of all available resources to find effective drugs against this scourge. Various ongoing researches have been searching for the new drug candidate against COVID-19 infection. The research objective is based on the molecular docking study of inhibition of the main protease of COVID- 19 by natural compounds found in Allium sativum and Allium cepa. Lipinski rule of five and Autodock 4.2 was used by using the Lamarckian Genetic Algorithm to perform Molecular docking to analyze the probability of docking. Further, ADME analysis was also performed by using SwissADME, which is freely available on the web. In the present study, we identified S-Allylcysteine sulfoxide (Alliin), S- Propyl cysteine, S-Allylcysteine, S-Ethylcysteine, S-Allylmercaptocysteine, S-Methylcysteine, S- propyl L-cysteine with binding energies (-5.24, -4.49, -4.99, -4.91, -4.79, -4.76, -5.0 kcal/mol) as potential inhibitor candidates for COVID-19. Out of 7 selected compounds, alliin showed the best binding efficacy with target protein 6LU7. In silico ADME analysis revealed that these compounds are expected to have a standard drug-like property as well. Our findings propose that natural compounds from garlic and onion can be used as potent inhibitors against the main protease of COVID-19, which could be helpful in combating the COVID-19 pandemic.
Garlic offers a broad-spectrum antimicrobial for GI pathogenic infections from bacteria to viruses to yeast/mold and Protozoa (i.e., giardia, Cryptosporidium, amoebae, H. pylori, and more). Take 1-2 capsules once or twice a day. Each capsule has five garlic cloves.*
Pandey, P., Khan, F., Kumar, A., Srivastava, A., & Jha, N. K. (2021). Screening of potent inhibitors against 2019 novel coronavirus (Covid-19) from Allium sativum and Allium cepa: An in silico approach. Biointerface Res Appl Chem, 11(1), 7981-93. Article
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The present review describes the potential of garlic phytochemicals for the improvement of the immune system against diseases in humans. Article
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