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Article: Brown Seaweed: Anti Viral Properties Against Covid.

Brown Seaweed: Anti Viral Properties Against Covid.

Dear Friend,

A 2020 governmental report examined the novel anti viral properties against SARS-CoV-2.  Algae or seaweed create a wide variety of potent bio-actives that can inhibit virus replication and attachment (Edmundson et al., 2020).

That is good news, however, would seaweed work against coronavirus? The report shows significant broad-spectrum antiviral properties against SARS-CoV and others including Ebola. Read this fascinating report, presented in October of 2020. 

Introduction

The lack of effective treatments for SARS-CoV-2 and other emerging viral pathogens has expanded the search for unique antiviral compounds. Algae from marine and extreme environments may provide novel compounds with novel activity for use in therapeutic drug development. Previously published research indicates that phototrophic organisms synthesize a large range of effective antiviral compounds, often with no or low cytotoxicity. Algae (broadly referring to cyanobacteria, eukaryotic microalgae and seaweeds) synthesize a wide range of bioactive compounds with antiviral potential, such as, nucleosides, polyphenols, sulfoglycolipids, lectins, sulfated polysaccharides, cyclic depsipeptides, β-carbolines, indolocarbazoles, and proteins, some of which have been demonstrated to inhibit virus replication and attachment. Indeed, some of these antiviral compounds are even active specifically against coronaviruses. Significantly, some algal-based compounds have been shown to have broad-spectrum antiviral activity (SARS-CoV, MERS-CoV, HCoV-229E, HCoV-OC43, HIV, HCV and Ebola), while also being well tolerated in vivo by rodents. Given the divergent phylogenies and respective biodiversity of biosynthetic pathways among cyanobacteria, eukaryotic microalgae, and marine macroalgae, we expect additional potent antivirals to exist. The antiviral activities of novel compounds synthesized by phototrophs, specifically against SARS-CoV-2, are not well characterized. Indeed, recent evidence indicates that anti-SARS-CoV-2 activity from algal bioproducts is an area in need of further research. Therefore, to develop effective and well-tolerated treatments for SARS-CoV-2 infections, as well as other emerging and evolving microbial pathogens (e.g., Influenza-A viruses), there is a critical need to discover novel compounds exhibiting potent antiviral activity without cytotoxicity. Article

 

Sincerely yours,

Seann

References

  • Edmundson, S. J., Huesemann, M. H., Cady, S. L., Kuo, L. J., Anderson, B., & Reynolds, D. (2020). VITAL-Viral InhibiTors from ALgae: Generating Extracts for Antiviral Activity Assays. Article
 

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