Borsom et al. (2020): Do the Bugs in Your Gut Eat Your Memories?
Dear Friend,
Do the Bugs in your gut eat your memories?
The simple answer is yes, the state of your microbiome or the organisms in your gut do affect the possibility of developing Alzheimer’s disease (AD), Parkinson disease and Autism Spectrum Disorder.
The more complicated answer is a thorough review study by Borson, Lee, & Cope (2020) with many ideas as to what to eat (more plants) and not eat (animal sourced fat), the kind of probiotics to take (Lactobacillus rhamnosus, Bifidobacterium) and the kind of organism that cause inflammation in the brain (Bacteroides).
With AD patients, there are more inflammation causing bacteroides in the gut and hence the brain, and not enough diversity of butyrate producing probiotics to reduce inflammation.
You have seen the many articles we have written on “inflammageing” – and indeed, as we age, we do produce more inflammation, a reason to be more intentional in eating a higher percentage of plant-based foods, taking a diverse and strong probiotic organisms, prebiotic, and polyphenols, add exercise, and bring more joy into your life.
Abstract:
The human microbiota is composed of trillions of microbial cells inhabiting the oral cavity, skin, gastrointestinal (GI) tract, airways, and reproductive organs. The gut microbiota is composed of dynamic communities of microorganisms that communicate bidirectionally with the brain via cytokines, neurotransmitters, hormones, and secondary metabolites, known as the gut microbiota–brain axis. The gut microbiota–brain axis is suspected to be involved in the development of neurological diseases, including Alzheimer’s disease (AD), Parkinson’s disease, and Autism Spectrum Disorder. AD is an irreversible, neurodegenerative disease of the central nervous system (CNS), characterized by amyloid-β plaques, neurofibrillary tangles, and neuroinflammation. Microglia and astrocytes, the resident immune cells of the CNS, play an integral role in AD development, as neuroinflammation is a driving factor of disease severity. The gut microbiota–brain axis is a novel target for Alzheimer’s disease therapeutics to modulate critical neuroimmune and metabolic pathways. Potential therapeutics include probiotics, prebiotics, fecal microbiota transplantation, and dietary intervention. This review summarizes our current understanding of the role of the gut microbiota–brain axis and neuroinflammation in the onset and development of Alzheimer’s disease, limitations of current research, and potential for gut microbiota–brain axis targeted therapies. Full-Article
Sincerely yours,
Seann
References
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Borsom, E. M., Lee, K., & Cope, E. K. (2020). Do the Bugs in Your Gut Eat Your Memories? Relationship between Gut Microbiota and Alzheimer’s Disease. Brain sciences, 10(11), 814. Full-Article
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