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Bladder infections and antibiotic-resistant bacteria

Dear Doctor

Bader (2017) update on the status of urinary tract infections (UTIs) emphasizes the growing concern of UTIs caused by antibiotic-resistant Gram-negative bacteria, such as E. coli, Salmonella, Klebeiella– all part of the family Enterobacteriaceae. Treating UTIs with drugs like Fosfomycin tromethamine, amoxicillin, and others are the typical course of action, but what do we do when these drugs do not resolve the UTI?

Proanthocyanidin from Cranberries and Pomegranates have been used for many years as anti-adhesive agents in the treatment of UTI. Gupta et al. (2012) showed in his study that a drug resistant E. coli was sensitive to an extract from cranberries on bladder infection by inhibiting the adhesiveness of multi-drug resistant E. coli to the walls. In 2015 Kaspar et al. assessed the anti-adhesion effect of cranberry extract to improve urinary tract health. More recently, the research and reviews of Lima et al. (2019) and González de Llanoet al. (2019) showed new findings on the efficacy of cranberries against urinary tract infections due to the rich source of phenolic compounds.

Cranberry Pomegranate Synbiotic has the added antimicrobial activity of pomegranate, with probiotics, supernatant and microRNA. 2-4 capsule three times a day for three days as intensive support or until condition resolved.

Order Now: Cranberry Pomegranate Synbiotic



  • Bader, M. S., Loeb, M., & Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine129(2), 242-258.Abstract
  • González de Llano, D., Liu, H., Khoo, C., Moreno-Arribas, M. V., & Bartolomé, B. (2019). Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria. Journal of agricultural and food chemistry67(8), 2166-2174.Article
  • Gupta, A., Dwivedi, M., Mahdi, A.A., Nagana Gowda, G.A., Khetrapal, C.L., Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin. Urol Res, 40(2), 143-50. DOI: 10.1007/s00240-011-0398-2
  • Kaspar, K.L., Howell, A.B., & Khoo, C. (2015). A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages.Food Funct, 6(4), 1212-7. DOI: 10.1039/c4fo01018c
  • Lima, M. C., de Sousa, C. P., Fernandez-Prada, C., Harel, J., Dubreuil, J. D., & de Souza, E. L. (2019). A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria. Microbial pathogenesis.Abstract
  • Rodríguez-Pérez, C., Quirantes-Piné, R., Uberos, J., Jiménez-Sánchez, C., Peña, A., & Segura-Carretero, A. (2016). Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli. Food & function7(3), 1564-1573. Article
  • Wafa, B. A., Makni, M., Ammar, S., Khannous, L., Hassana, A. B., Bouaziz, M., … & Gdoura, R. (2017). Antimicrobial effect of the Tunisian Nana variety Punica granatum L. extracts against Salmonella enterica (serovars Kentucky and Enteritidis) isolated from chicken meat and phenolic composition of its peel extract. International journal of food microbiology241, 123-131. DOI: 10.1016/j.ijfoodmicro.2016.10.007

To your health,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Transformation to healthy diets by 2050 will require substantial dietary shifts.  Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits.  (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)


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