Beta Glucan and Crohn's Disease
Crohn’s Disease has an intense cycle of exacerbation period with remission and then back to exacerbation. Inflammation leads to fistulas, abscesses or intestinal strictures are part of the complications and pain.
Dietotherapy is defined as a food therapy to promote health as well as handle chronic conditions that seemingly do not resolve easily. In this case, beta glucan was used to reduce colitis and accelerate remission of Chron’s Disease (Żył et al., 2020).
This article, Anti-Inflammatory Activity of Oat Beta-Glucans in a Crohn’s Disease Model, is very promising with a food therapy solution that is elegant and straight forward.
Enjoy the article check out BioImmersion’s Beta-Glucan
Abstract
Background: The incidence of Crohn’s disease (CD) is increasing worldwide, and it has currently become a serious public health issue in society. The treatment of CD continues throughout a patient’s lifetime, and therefore, it is necessary to develop new, effective treatment methods, including dietotherapy. The present study aimed to determine the effects of consumption of oat beta-glucans with different molar mass on colon inflammation (colitis) in the early stages of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced CD in an animal model. Methods: Sprague–Dawley rats (control and TNBS-induced CD) were divided into three dietary groups and fed for 3 days (reflecting acute inflammation) or 7 days (reflecting remission) with a feed containing 1% low (βGl) or high (βGh) molar mass oat beta-glucan or a feed without this polysaccharide. The level of colon inflammatory markers and the expression of cytokines and their receptor genes were measured by ELISA and RT-PCR methods, respectively. Results: Acute inflammation or remission (3 or 7 days after TNBS administration, respectively) stages of experimentally induced CD were characterized by an increase in the level of inflammatory markers (IL-1, IL-6, IL-10, IL-12, TNF-α, CRP, MPO, COX, and PGE2) and the disruption of some cytokine signaling pathways as well as macro- and microscopic changes of colon tissue. The consumption of oat beta-glucans reduced the level of inflammatory markers and recovered the signaling pathways and histological changes, with stronger effects of βGl after 7 days of colitis. Conclusions: Dietary oat beta-glucans can reduce colitis at the molecular and organ level and accelerate CD remission. Article
Beta Glucan Formula can protect us from developing heart disease, metabolic syndrome, diabetes, leaky gut, as well as train our front line immune system.
Suggested use: one heaping tablespoon daily in a large glass of water.
References:
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Żyła, E., Dziendzikowska, K., Kamola, D., Wilczak, J., Sapierzyński, R., Harasym, J., & Gromadzka-Ostrowska, J. (2021). Anti-Inflammatory Activity of Oat Beta-Glucans in a Crohn’s Disease Model: Time-and Molar Mass-Dependent Effects. International Journal of Molecular Sciences, 22(9), 4485. Article
Sincerely yours,
Seann
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Green Facts:
Read this educational article on beta glucan and probiotics by Russo et al. 2012: Article Beta-glucans improve growth, viability and colonization of probiotic microorganisms.
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