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2020 Research: Intestinal Dysbiosis & Inflammatory Response to SARS-CoV-2

Terruzzi & Senesi published this article in 2020 before vaccines were available and showed the depth of scientific examination of different nutritional strategies that support the more frail population - people with chronic conditions. 

It is also of importance to note the ongoing intense discussions within the scientific community on the need for an overall strategy to improve the health condition of all people in our world, and of course, to improve the way we handle pandemics.

The researchers reviewed the possible molecular mechanism of intestinal dysbiosis, the inflammation dysbiosis causes, and the effect on spreading SARS- CoV-2 infection and some nutritional strategies to counteract inflammation.

Terruzzi & Senesi emphasize prebiotics, especially inulin, probiotics, and polyphenols from fruits and vegetables, for the purpose of lowering inflammation. 


In a few months, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become the main health problem worldwide. Epidemiologic studies revealed that populations have different vulnerabilities to SARS-CoV-2. Severe outcomes of the coronavirus disease 2019 (COVID-19) with an increased risk of death are observed in patients with metabolic syndrome, as well as diabetic and heart conditions (frail population). Excessive proinflammatory cytokine storm could be the main cause of increased vulnerability in this frail population. In patients with diabetes and/or heart disease, a low inflammatory state is often associated with gut dysbiosis. The increase amount of microbial metabolites (i.e., trimethylamine N-oxide and lipopolysaccharide), which generate an inflammatory microenvironment, is probably associated with an improved risk of severe illness from COVID-19. Nutritional interventions aimed at restoring the gut microbial balance could represent preventive strategies to protect the frail population from COVID-19. This narrative review presents the possible molecular mechanisms by which intestinal dysbiosis that enhances the inflammatory state could promote the spread of SARS-CoV-2 infection. Some nutritional strategies to counteract inflammation in frail patients are also analyzed. Article


Original Synbiotic 

Original Synbiotic 

 Suggested use: One teaspoon by mouth (very tasty) or mixed in a little water. 

conclusion from the article:

"Modulation of the microbiome through diet or probiotic/prebiotic agents is well known to ameliorate an inflammation state. In this work, we reviewed some nutritional interventions, focusing on gut microbiota, aimed at improving low-grade inflammation conditions. Currently, the consumption of probiotic/prebiotic agents, polyphenols, or oligofructose/inulin counteracts gut dysbiosis and ameliorates the inflammation state. Future advances on the knowledge of COVID-19 molecular mechanisms would lead to an improved understanding of interactions between SARS-CoV-2 and gut microbiota. In perspective, after microbiota analyses, a novel personalized nutritional approach can be developed to restore a healthy gut microbiota and avoid SARS-CoV-2-induced exacerbated inflammation in frail patients." (Terruzzi & Senesi, 2020).


  • Terruzzi, I., & Senesi, P. (2020). Does intestinal dysbiosis contribute to an aberrant inflammatory response to SARS-CoV-2 in frail patients?. Nutrition, 110996. Article
  • Wong, W. Y., Chan, B. D., Leung, T. W., Chen, M., & Tai, W. C. S. (2022). Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice. Journal of Functional Foods88, 104871. Article

Sincerely yours,

Dohrea and Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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And more on Probiotics and IBD:

Zhang, X. F., Guan, X. X., Tang, Y. J., Sun, J. F., Wang, X. K., Wang, W. D., & Fan, J. M. (2021). Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in inflammatory bowel disease: A systematic review and meta-analysis. European journal of nutrition, 1-21. Abstract 

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