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Type 2 Diabetes, Lipid Profile, and Chromium

Recent research review on chromium finds that chromium positively affects the lipid profile in patients with type 2 diabetes. Chromium reduces serum levels of triglyceride and total cholesterol. 

Chromium also increased HDL (the good cholesterol) but did not show effect on lipoprotein (LDL, or the 'bad cholesterol') (Asbaghi et al., 2021).



The purpose of this study was to determine the influence of chromium supplementation on lipid profile in patients with type 2 diabetes mellitus (T2DM).


A systematic search was performed in Scopus, Embase, Web of Science, the Cochrane library and PubMed databases to find randomized controlled trials (RCTs) related to the effect of chromium supplementation on lipid profile in patients with T2DM, up to June 2020. Meta-analyses were performed using the random-effects model, and I2 index was used to evaluate heterogeneity.


The primary search yielded 725 publications. 24 RCTs (with 28 effect size) were eligible. Our meta-analysis indicated that chromium supplementation resulted in a significant decrease in serum levels of triglyceride (TG) (MD: -6.54 mg/dl, 95 % CI: -13.08 to -0.00, P = 0.050) and total cholesterol (TC) (WMD: -7.77 mg/dl, 95 % CI: -11.35 to -4.18, P < 0.001). Furthermore, chromium significantly increases high-density lipoprotein (HDL) (WMD: 2.23 mg/dl, 95 % CI: 0.07–4.40, P = 0.043) level. However, chromium supplementation did not have significant effects on low-density lipoprotein (LDL) (WMD: -8.54 mg/dl, 95 % CI: -19.58 to 2.49, P = 0.129) level.


Chromium supplementation may significantly improve lipid profile in patients with T2DM by decreasing TG and TC and increasing HDL. However, based on our analysis, chromium failed to affect LDL. It should be noted that the lipid-lowering properties of chromium supplementation were small and may not reach clinical importance.

Chromium with High Active Beet Root

Each capsule of the Chromium with High Active Beet Root provides 500 micrograms of trivalent chromium polynicotinate (50mcg of elemental chromium) and 250 mg of High Active red beet root with a standardized 10,000ppm plant nitrate, which the body converts to nitric oxides (McDonagh et al., 2018).



  • Asbaghi, O., Naeini, F., Ashtary-Larky, D., Moradi, S., Zakeri, N., Eslampour, E., ... & Naeini, A. A. (2021). Effects of chromium supplementation on lipid profile in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of randomized controlled trials. Journal of Trace Elements in Medicine and Biology66, 126741. Abstract
  • McDonagh, S. T., Wylie, L. J., Thompson, C., Vanhatalo, A., & Jones, A. M. (2019). Potential benefits of dietary nitrate ingestion in healthy and clinical populations: A brief review. European journal of sport science19(1), 15-29. Article


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.


Green Facts:

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Ninfali P, Antonini E, Frati A, Scarpa ES. (2017). C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review. Phytother Res, 31(6), 871-884. Abstract


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