Supernatant: Hard to Treat Non-Candida Yeast Infections
Most cases of vaginal yeast infection are caused by C. albicans. However, there is a rapid increase in infections that are not caused by Candida species, and they are hard to treat.
In particular, a persistent infection that is resistant to anti-final is caused by C. parapsilosis.
This 2022 research article shows that Supernatant that is obtained from L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri - All in the No 7 systemic-booster - are very effective against C. parapsilosis.
See the Abstract below for more information.
No 7 Systemic Booster: The New Longevity: 1-2 heaping tsp daily. To activate the Supernatant and ORNs (for immune boosting), put a teaspoonful in your mouth and let it dissolve. Or mix it with water and slowly drink. It is so tasty!
Vulvovaginal candidiasis (VVC) is a common clinical condition with symptoms and signs of vaginal inflammation in the presence of Candida species. At least one episode of VVC is experienced in up to 75% of women in the reproductive age group during their lifetime, and 5% to 8% of such women suffer from the chronic form. Most cases of VVC are still caused by C. albicans. However, the incidence of VVC cases by non-albicans Candida (NAC) species, such as C. parapsilosis, is continuously increasing. Despite the prevalence of VVC from NAC, little is known about these species and almost nothing about the mechanisms that trigger the VVC. Lactobacillus spp. are the most widely before represented microorganisms in the vaginal microbiota of healthy women. Here, cell-free supernatants (CFS) obtained from L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri were assessed for their effect on C. parapsilosis virulence traits. Moreover, we assessed if such an effect persisted even after the removal of the CFS (CFS preincubation effect). Moreover, a transwell coculture system was employed by which the relevant antifungal effect was shown to be attributable to the compounds released by lactobacilli. Our results suggest that lactobacilli can work (i) by reducing C. parapsilosis virulence traits, as indicated by the reduced fungal proliferation, viability, and metabolic activity, and (ii) by improving epithelial resistance to the fungus. Overall, these data suggest that, in the context of the vaginal microbiota, the lactobacilli may play a role in preventing the onset of mucosal C. parapsilosis infection. Article
Spaggiari, L., Sala, A., Ardizzoni, A., De Seta, F., Singh, D. K., Gacser, A., ... & Pericolini, E. (2022). Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System In Vitro. Microbiology Spectrum, e02696-21. Article
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Danilova, T. A., Danilina, G. A., Adzhieva, A. A., Polyakov, N. B., & Zhukhovitskii, V. G. (2022). Antibacterial Activity of Lactobacillus plantarum Supernatant on Non-Fermenting Gram-Negative Bacteria. Bulletin of Experimental Biology and Medicine, 1-4. Abstract
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