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Prevention of Type 2 Diabetes with Bioactive Peptides from Ancient Seeds

With worldwide increase of Type 2 diabetes, scientists are looking for functional foods as preventative and to possibly even target the disease.

The beautiful thing about the 3 ancient seeds is their ability to handle multiple health issues and so elegantly. Could it be that the good results on type 2 diabetes and hypertension are from their bioactive peptides?

Ancient seeds have a certain energizing and empowering properties that nourishes us on a fundamental level. 

In this year comprehensive review, Valenzuela & Segura (2022) focus on the Bio-Active Peptides from ancient seeds of Chia, Amaranth and Quinoa. 

Their conclusion: There is high occurrence of bioactive peptides in these seeds that have anti-diabetes and anti-hypertension effects. Not all bio-actives were examined and discussed in this review but they do play a big role on anti-diabetes effect (i.e., antioxidants & anti-inflammatory) as well as, the article did not examine their prebiotic feature which brings balance to the microbiome. We shall look at these features in later research. Article


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Staff of Life

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Worldwide prevalence of Type 2 Diabetes (T2D) has become a major concern with several implications for public health, economy, and social well-being, especially in developing countries. Conventional pharmacological management of T2D have proved effective, but possess underlying side effects, leading the scientific community to research alternative compounds that exert beneficial effects on current therapeutic targets of T2D. Bioactive peptides (BAPs) from food sources, have shown relative advantages in this matter, moreover, BAPs have proved to impart anti-diabetic activity through one or more mechanisms such as enzymatic inhibition of α-glucosidase, α-amylase and DPP–IV. Several plants and animal have been used as protein sources of anti-diabetic BAPs, in the sense of this matter, the pseudo-cereals amaranth and quinoa, along with the ancestral grain chia, have gained attention. Due, to their high protein content and balanced amino-acid composition, along with proved anti-diabetic features, the three seeds are top choices for the obtention of anti-diabetic BAPs. With a comprehensive overview of the most recent reported in silico and in vitro anti-diabetic studies in relation to biomarkers α-glucosidase, α-amylase and DPP-IV, the present review aims to examine the current knowledge of amaranth, quinoa and chia derived anti-diabetic BAPs and their effects on T2D therapeutic markers.


  • Valenzuela Zamudio, F., & Segura Campos, M. R. (2022). Amaranth, quinoa and chia bioactive peptides: a comprehensive review on three ancient grains and their potential role in management and prevention of Type 2 diabetes. Critical Reviews in Food Science and Nutrition62(10), 2707-2721. Article
  • Zamudio, F. V., Hidalgo-Figueroa, S. N., Andrade, R. R. O., Álvarez, A. J. H., & Campos, M. R. S. (2022). Identification of antidiabetic peptides derived from in silico hydrolysis of three ancient grains: Amaranth, Quinoa and Chia. Food Chemistry, 394, 133479

      We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

      Green Facts:

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      How good are these seeds for your microbiome?

      Arslan-Tontul, S., Candal Uslu, C., Mutlu, C., & Erbaş, M. (2022). Expected glycemic impact and probiotic stimulating effects of whole grain flours of buckwheat, quinoa, amaranth and chia. Journal of Food Science and Technology, 59(4), 1460-1467. Article

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