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Mitochondria, Oxidative Stress, and Aging Skin

Mitochondria has been in the center of scientific interest for decades, but recently it has picked up steam. 

What are the reasons for this renewed interest?

And as always in medicine, it is the study of how disease is formed, and how to counterbalance and prevent disease.

Mitochondria, as we know, create energy for cellular function, and in fact , for all our biological processes. Most of our cells have mitochondria, although the muscles, the liver and kidneys, brain and nerve cells, have more. 

But mitochondria play even a bigger and more critical role - they are storage area for calcium (for blood clotting and muscle contraction), produce iron (for red blood cells to transport oxygen), and even more amazing - they actually trigger cell death.  

Recent studies are showing that when things go wrong in the mitochondria - disease occurs, for example, Parkinson's. This is the reason Pfizer has acknowledged that mitochondria is "the organelle of the moment" (2023). 

Much of our internal cellular oxidative stress is due to the hard work of the mitochondria. 

Externally, environmental toxins, the sun, and pollution, alongside our own lifestyle habits, also stimulate reactive oxygen species and generate oxidative stress (Naidoo & Birch-Machin, 2017). 

Both internal and external oxidative stress is showing to be the cause of our aging skin. 

The solution is simple, and not so simple.

Simple, because diet filled with fruits and veggies have polyphenols which are powerful antioxidants, important to counteract and counterbalance the oxidative process. And this in itself can slow down the aging of the skin. 

But it is not so easy (and hence not simple) to eat 5-7 fruits and vegetables a day.

The good news is that antioxidant supplements, with polyphenols, are showing in research to protect skin against ultraviolet radiation from the sun and also against other environmental sources that create oxidative stress, such as pollution or toxins. 

Interestingly, taking vitamin E, A, and beta-carotene had no effect on skin aging and in fact, high amounts may be causing even more damage, possibly to the mitochondria. 

The body is very specific on what works and what does not work: Antioxidants that are polyphenols from foods are showing good results (Naidoo & Birch-Machin, 2017). 

Read the articles below in the reference section to find out more about aging, mitochondria, and antioxidants from foods. Enjoy! 

Part of the reason the High ORAC Synbiotic is designated to be a post antibiotic care is due to this beautiful research - the intense oxidation throughout the body and dysbiosis in the gut.  


The High ORAC is a potent polyphenol antioxidant. One capsule daily. 


  • Liu, H. M., Cheng, M. Y., Xun, M. H., Zhao, Z. W., Zhang, Y., Tang, W., ... & Wang, W. (2023). Possible Mechanisms of Oxidative Stress-Induced Skin Cellular Senescence, Inflammation, and Cancer and the Therapeutic Potential of Plant Polyphenols. International Journal of Molecular Sciences24(4), 3755. Article
  • Naidoo, K., & Birch-Machin, M. A. (2017). Oxidative stress and ageing: the influence of environmental pollution, sunlight and diet on skin. Cosmetics4(1), 4. Article
  • Pfizer. (2016, November 28). Why mitochondrea is the organelle of the moment [blog post]. Retrieved from

Yours as always,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.


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And finally, the American Psychological Association is realizing how important qualitative research is for understanding all human beings, hearing all voices, and accumulating data in ethical and inclusive methods.

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