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Fructo Borate Complex
Fructo Borate Complex
Fructo Borate Complex

Fructo Borate Complex

$37.94

The Fructo Borate Complex is a new form of boron based on the organic mineral structure found in whole foods.

Exceptionally bio-available, Fructo Borate is highly effective for joint and bone health. This organic form of boron is able to cross the gastrointestinal barrier into the systemic circulation intact with its carbohydrate linkage.

As a master mineral, boron is responsible for the support of many metabolic pathways: the osteo-skeletal system, endocrine system, and immune system. Boron supplementation is important due to faulty farming practices that have depleted boron from the soil.

The Fructo Borate is Vegan, Kosher, Non GMO, and Gluten Free.

New form of boron supplementation that is the exact molecular structure of dietary boron found in fruits, vegetables and nuts. US Patent #US 5962049 A. Fructo Borate 240 mg with calcium ascorbate 260 mg provides 6 mg of elemental boron. No excipients. 60 capsules per bottle. 500 mg per vegetarian capsule.

  • Patented Technology creates a highly effective Fructo Borate molecule.
  • 240mg fructoborate and 260mg calcium ascorbate per vegetarian capsule.
  • Each capsule supplies 6mg of elemental boron.
  • New form of boron supplementation: US patented carbohydrate bound boron.
  • Exact duplicate of dietary boron found in fruits, vegetables and nuts.
  • Association Constant high: Receptor sites receive entire molecule.
  • Osteoporosis: Reduces excretion of Mg and Ca, re-mineralizes bone.
  • Use therapeutically against osteoarthritis: Reduces pain and swelling and increases mobility.
  • Down-regulates immune system: Reduces over-reactive neutrophil levels.
  • Anti-oxidant: Increases SOD and Catalase production.
  • Anti-aging: Increases Vitamin D and Steroid hormone levels in the blood.
  • Anti-cancer: Reduces PSA marker for prostate cancer.
  • Clinical trial: 1 to 2 capsules BID to reduce pain and regenerate bone; 1 capsule daily for maintenance. Observed results period is from 2-8 weeks.
  • No filler, flowing agents or excipients of any kind.

FOOD SCIENCE: THE APPLICATION AND USE OF Fructo Borate [plant-based Dietary boron].*

Arthritis and Osteoporosis: Bone and Joint Health

Baldivia, A. S. (2016). 10. Will boron be essential for human nutrition?. Archivos Latinoamericanos de Nutrición66(1). Article

Bartl, R., & Bartl, C. (2019). A Step-by-Step Programme for Healthy Bones. In The Osteoporosis Manual (pp. 137-150). Springer, Cham. Abstract

Beattie, J. H., & Peace, H. S. (1993). The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. British journal of nutrition69(3), 871-884. Article

Boyacioglu, O., Orenay-Boyacioglu, S., Yildirim, H., & Korkmaz, M. (2018). Boron intake, osteocalcin polymorphism and serum level in postmenopausal osteoporosis. Journal of Trace Elements in Medicine and Biology48, 52-56. Abstract

Bunker, V. W. (1994). The role of nutrition in osteoporosis. British journal of biomedical science51(3), 228-240. Abstract

Devirian, T. A., & Volpe, S. L. (2003). The physiological effects of dietary boron. Article

Gaby, A. R. (1999). Natural treatments for osteoarthritis. Alternative Medicine Review4, 330-341. Article

Goldstein, M. C., & Goldstein, M. A. (2018). Vitamins and Minerals: Fact Versus Fiction. ABC-CLIO. BookP.4-5

Helliwell, T. R., Kelly, S. A., Walsh, H. P. J., Klenerman, L., Haines, J., Clark, R., & Roberts, N. B. (1996). Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthrosis. Bone18(2), 151-157. Abstract

Hunter, J. M., Nemzer, B. V., Rangavajla, N., Biţă, A., Rogoveanu, O. C., Neamţu, J., ... & Mogoşanu, G. D. (2019). The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review. Biological trace element research188(1), 11-25. Article

Jain, R., & Tiwari, A. (2019). Boron: A dietary mineral for human health. Apollo Medicine16(1), 66. Article

Khaliq, H., Juming, Z., & Ke-Mei, P. (2018). The physiological role of boron on health. Biological trace element research186(1), 31-51. Article

Lewiecki, E. M., Bilezikian, J. P., Carey, J. J., Dell, R. M., Gordon, C. M., Harris, S. T., ... & Rosenblatt, M. (2018). Proceedings of the 2017 Santa Fe Bone Symposium: insights and emerging concepts in the management of osteoporosis. Journal of Clinical Densitometry21(1), 3-21. Article

Lu, X., Li, K., Xie, Y., Qi, S., Shen, Q., Yu, J., ... & Zheng, X. (2019). Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects. Journal of Biomedical Materials Research Part A107(1), 12-24. Article

McCoy, H., Kenney, M. A., Montgomery, C., Irwin, A., Williams, L., & Orrell, R. (1994). Relation of boron to the composition and mechanical properties of bone. Environmental Health Perspectives102(suppl 7), 49-53. Article

Maslin, K., & Dennison, E. (2019). Diet and Bone Health. In Analysis in Nutrition Research (pp. 337-354). Academic Press. Chapter13

Meacham, S. L., Taper, L. J., & Volpe, S. L. (1994). Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes. Environmental health perspectives102(suppl 7), 79-82. Article

Miljkovic, D., Scorei, R. I., Cimpoiaşu, V. M., & Scorei, I. D. (2009). Calcium fructoborate: plant-based dietary boron for human nutrition. Journal of dietary supplements6(3), 211-226. Article

Moustafa, S. R. (2019). Relationship of some ultra trace elements with atherosclerosis. Zanco Journal of Medical Sciences (Zanco J Med Sci)23(1), 66-73. Article

Morelli, V., Naquin, C., & Weaver, V. (2003). Alternative therapies for traditional disease states: osteoarthritis. American Family Physician67(2), 339-346. Article

Newnham, R. E. (2002). How boron is being used in medical practice. In Boron in plant and animal nutrition (pp. 59-62). Springer, Boston, MA. Abstract

Newnham, R.E. (1994). Essentiality of boron for health bones and joints. Environmental health perspective, 102 (suppl 7), 83-85. Article

Nielsen, F. H. (2014). Update on human health effects of boron. Journal of Trace Elements in Medicine and Biology28(4), 383-387. Abstract

Nielsen, F. H. (2008). Is boron nutritionally relevant?. Nutrition reviews66(4), 183-191. Article

Nielsen, F. H. (1990). Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones [electronic resource]. Magnesium and trace elements9(2), 61. Article

Nielsen, F. H., Hunt, C. D., Mullen, L. M., & Hunt, J. R. (1987). Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. The FASEB journal1(5), 394-397. Article 

Pietrzkowski, Z., Mercado-Sesma, A. R., Argumedo, R., Cervantes, M., Nemzer, B., & Reyes-Izquierdo, T. (2018). Effects of once-daily versus twice daily dosing of calcium fructoborate on knee discomfort. A 90 day, double-blind, placebo controlled randomized clinical study. J Aging Res Clin Pract7(1), 31-36. Article

Pizzorno, L. (2015). Nothing boring about boron. Integrative Medicine: A Clinician's Journal14(4), 35. Article

Prejac, J., Skalny, A. A., Grabeklis, A. R., Uzun, S., Mimica, N., & Momčilović, B. (2018). Assessing the boron nutritional status by analyzing its cummulative frequency distribution in the hair and whole blood. Journal of Trace Elements in Medicine and Biology45, 50-56. Article

Price, C. T., Langford, J. R., & Liporace, F. A. (2012). Essential nutrients for bone health and a review of their availability in the average North American diet. The open orthopaedics journal6, 143. Article

Rico, H. (1991). Minerals and osteoporosis. Osteoporosis International2(1), 20-25. Review

Scorei, R., Mitrut, P., Petrisor, I., & Scorei, I. (2011). A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis. Biological trace element research144(1-3), 253-263. Article

Travers, R. L., Rennie, G. C., & Newnham, R. E. (1990). Boron and arthritis: the results of a double-blind pilot study. Journal of Nutritional Medicine1(2), 127-132. Abstract

Volpe, S. L., Taper, L. J., & Meacham, S. (1993). The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnesium research6(3), 291-296. Abstract

Zhang, J. (2018). Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis. BMC musculoskeletal disorders19(1), 22. Article

Brain, Heart, Lung & Breast Health

Altinoz, M. A., Topcu, G., & Elmaci, İ. (2019). Boron’s neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment. International Journal of Neuroscience, 1-15. Article

Bakirdere, S., Orenay, S., & Korkmaz, M. (2010). Effect of boron on human health. The Open Mineral Processing Journal3(1). Article

Cui, Y., Winton, M. I., Zhang, Z. F., Rainey, C., Marshall, J., De Kernion, J. B., & Eckhert, C. D. (2004). Dietary boron intake and prostate cancer risk. Oncology reports11(4), 887-892. Article

Donoiu, I., Militaru, C., Obleagă, O., Hunter, J. M., Neamţu, J., Biţă, A., ... & Rogoveanu, O. C. (2018).Effects of Boron-Containing Compounds on Cardiovascular Disease Risk Factors–A Review. Journal of Trace Elements in Medicine and Biology. Article

Gaby, A. R., & Wright, J. V. (1990). Nutrients and osteoporosis. Journal of Nutritional Medicine1(1), 63-72. Article

Kuru, R., Yilmaz, S., Balan, G., Tuzuner, B. A., Tasli, P. N., Akyuz, S., ... & Sahin, F. (2019). Boron-rich diet may regulate blood lipid profile and prevent obesity: A non-drug and self-controlled clinical trial. Journal of Trace Elements in Medicine and Biology54, 191-198. Abstract

Penland, J. G. (1994). Dietary boron, brain function, and cognitive performance. Environmental health perspectives102(suppl 7), 65-72. Article

Ozdemir, H., Yaren, B., & Oto, G. (2019). Effect of dietary boron on learning and behavior in rats administered with boric acid. Cell Mol Biol (Noisy le Grand)65(1). Article

Scorei, I. R. (2011). Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy. Front Biosci (Schol Ed)3, 205-215. Article

Scorei, R., Ciubar, R., Ciofrangeanu, C. M., Mitran, V., Cimpean, A., & Iordachescu, D. (2008). Comparative effects of boric acid and calcium fructoborate on breast cancer cells. Biological trace element research122(3), 197-205. Abstract

Simsek, F., Inan, S., & Korkmaz, M. (2019). An in Vitro Study in Which New Boron Derivatives Maybe an Option for Breast Cancer Treatment. breast cancer13, 14. Article

Vijay Bhasker, T., Gowda, N. K. S., Krishnamoorthy, P., Pal, D. T., Sejian, V., Awachat, V. B., & Verma, A. K. (2017). Boron supplementation provides hepato-protective effect and improves performance in Wistar rats fed calcium deficit diet. Indian J Anim Sci87(10), 1213-1218. Article

Anti-inflammatory & Longevity

Acaroz, U., Ince, S., Arslan-Acaroz, D., Gurler, Z., Kucukkurt, I., Demirel, H. H., ... & Zhu, K. (2018). The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats. Food and chemical toxicology118, 745-752. Abstract

Nielsen, F. H. (2018). Boron in Aging and Longevity. In Trace Elements and Minerals in Health and Longevity (pp. 163-177). Springer, Cham. Abstract

Scorei, R. I., & Rotaru, P. (2011). Calcium fructoborate—potential anti-inflammatory agent. Biological trace element research143(3), 1223-1238. Article

Scorei, R. I., Ciofrangeanu, C., Ion, R., Cimpean, A., Galateanu, B., Mitran, V., & Iordachescu, D. (2010). In vitro effects of calcium fructoborate upon poduction of inflammatory mediators by LPS-stimulated RAW 264.7 macrophages. Biological trace element research135(1-3), 334-344. Article

Scorei, R., Ciubar, R., Iancu, C., Mitran, V., Cimpean, A., & Iordachescu, D. (2007). In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes. Biological trace element research118(1), 27-37. Article

Scorei, R., Cimpoiasu, V. M., & Iordachescu, D. (2005). In vitro evaluation of the antioxidant activity of calcium fructoborate. Biological trace element research107(2), 127-134. Abstract

Boron and Polyphenols: Fructo Borate in No 7 Systemic Booster (or with High ORAC)

Arjmandi, B. H., Johnson, C. D., Campbell, S. C., Hooshmand, S., Chai, S. C., & Akhter, M. P. (2010). Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. Journal of medicinal food13(2), 312-319. Abstract  [High ORAC]

Austermann, K., Baecker, N., Stehle, P., & Heer, M. (2019). Putative Effects of Nutritive Polyphenols on Bone Metabolism In Vivo—Evidence from Human Studies. Nutrients11(4), 871. Article

Basu, S., Michaëlsson, K., Olofsson, H., Johansson, S., & Melhus, H. (2001). Association between oxidative stress and bone mineral density. Biochemical and biophysical research communications288(1), 275-279. Abstract

Brondani, J. E., Comim, F. V., Flores, L. M., Martini, L. A., & Premaor, M. O. (2019). Fruit and vegetable intake and bones: A systematic review and meta-analysis. PloS one14(5), e0217223. Article

Domazetovic, V., Marcucci, G., Pierucci, F., Bruno, G., Di Cesare Mannelli, L., Ghelardini, C., ... & Vincenzini, M. T. (2019). Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT 1. FEBS open bio. Article

Garrett, I. R., Boyce, B. F., Oreffo, R. O., Bonewald, L., Poser, J., & Mundy, G. R. (1990). Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. The Journal of clinical investigation85(3), 632-639. Article

Hardcastle, A. C., Aucott, L., Reid, D. M., & Macdonald, H. M. (2011). Associations between dietary flavonoid intakes and bone health in a Scottish population. Journal of Bone and Mineral Research26(5), 941-947. Article

Hubert, P., Lee, S., Lee, S. K., & Chun, O. (2014). Dietary polyphenols, berries, and age-related bone loss: A review based on human, animal, and cell studies. Antioxidants3(1), 144-158. Article

Koch, W. (2019). Dietary Polyphenols—Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review. Nutrients11(5), 1039. Article

Lobene, A. J., McCabe, L. D., Stone, M. S., Kindler, J. M., Bailey, R. L., Moshfegh, A. J., ... & Weaver, C. M. (2019). Dietary Mineral Intake Ratios and Bone Health in Adults. In Nutritional Influences on Bone Health (pp. 53-67). Springer, Cham. Abstract

New, S. A., Robins, S. P., Campbell, M. K., Martin, J. C., Garton, M. J., Bolton-Smith, C., ... & Reid, D. M. (2000). Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?. The American journal of clinical nutrition71(1), 142-151. Article

Welch, A., MacGregor, A., Jennings, A., Fairweather‐Tait, S., Spector, T., & Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. Journal of Bone and Mineral Research27(9), 1872-1878. Article

Welch, A. A., & Hardcastle, A. C. (2014). The effects of flavonoids on bone. Current osteoporosis reports12(2), 205-210. Abstract

Welch, A., MacGregor, A., Jennings, A., Fairweather‐Tait, S., Spector, T., & Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. Journal of Bone and Mineral Research27(9), 1872-1878. Article

Weitzmann, M. N. (2013). The role of inflammatory cytokines, the RANKL/OPG axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis. Scientifica2013. Article

Yahia, E. M., García-Solís, P., & Celis, M. E. M. (2019). Contribution of Fruits and Vegetables to Human Nutrition and Health. In Postharvest Physiology and Biochemistry of Fruits and Vegetables (pp. 19-45). Woodhead Publishing. Abstract

Zhang, Z. Q., He, L. P., Liu, Y. H., Liu, J., Su, Y. X., & Chen, Y. M. (2014). Association between dietary intake of flavonoid and bone mineral density in middle aged and elderly Chinese women and men. Osteoporosis International25(10), 2417-2425. Abstract

One capsule contains:
Vitamin C (from Calcium Ascorbate)  234mg    400%DV
Calcium (from Calcium Ascorbate)  26mg     3%DV
Fructo Borate Complex (yields 6mg elemental Boron)  240mg 

Other Ingredients:  Cellulose &water (capsule shell).


FRUCTO BORATE — The Fructo Borate is designed to reduce osteoarthritis’ joint pain and swelling, and increase joint mobility.*

Anti-inflammation and reduction of joint pain: Clinical trials suggest 1-2 capsules twice a day.*

Bone health: Fructo Borate helps to re-mineralize and strengthen bones, increases absorption of vitamin D, calcium, and magnesium. Take 1-2 caps a day.*

Heart health: Boron is shown to lower C-reactive proteins (marker for cardiovascular disease). Take 1-2 caps a day.*

Lung & immune support: Take 1-2 caps a day as anti-inflammatory for lung congestion (can take up to 6 a day for 2 days, reduce to 2-4 caps a day). Take 1-2 caps at the onset of a cold or flu.*

Our favorite: The master mineral, boron, in the Fructo Borate is in command of so many functions in the body. We add it to many of our protocols to enhance healing. Since Frcuto Borate mimics the boron in foods, it is exceptionally available.*

Description 

New form of boron supplementation that is the exact molecular structure of dietary boron found in fruits, vegetables and nuts. US Patent #US 5962049 A. Fructo Borate 240 mg with calcium ascorbate 260 mg provides 6 mg of elemental boron. No excipients. 60 capsules per bottle. 500 mg per vegetarian capsule.

  • Patented Technology creates a highly effective Fructo Borate molecule.
  • 240mg fructoborate and 260mg calcium ascorbate per vegetarian capsule.
  • Each capsule supplies 6mg of elemental boron.
  • New form of boron supplementation: US patented carbohydrate bound boron.
  • Exact duplicate of dietary boron found in fruits, vegetables and nuts.
  • Association Constant high: Receptor sites receive entire molecule.
  • Osteoporosis: Reduces excretion of Mg and Ca, re-mineralizes bone.
  • Use therapeutically against osteoarthritis: Reduces pain and swelling and increases mobility.
  • Down-regulates immune system: Reduces over-reactive neutrophil levels.
  • Anti-oxidant: Increases SOD and Catalase production.
  • Anti-aging: Increases Vitamin D and Steroid hormone levels in the blood.
  • Anti-cancer: Reduces PSA marker for prostate cancer.
  • Clinical trial: 1 to 2 capsules BID to reduce pain and regenerate bone; 1 capsule daily for maintenance. Observed results period is from 2-8 weeks.
  • No filler, flowing agents or excipients of any kind.

Research

FOOD SCIENCE: THE APPLICATION AND USE OF Fructo Borate [plant-based Dietary boron].*

Arthritis and Osteoporosis: Bone and Joint Health

Baldivia, A. S. (2016). 10. Will boron be essential for human nutrition?. Archivos Latinoamericanos de Nutrición66(1). Article

Bartl, R., & Bartl, C. (2019). A Step-by-Step Programme for Healthy Bones. In The Osteoporosis Manual (pp. 137-150). Springer, Cham. Abstract

Beattie, J. H., & Peace, H. S. (1993). The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. British journal of nutrition69(3), 871-884. Article

Boyacioglu, O., Orenay-Boyacioglu, S., Yildirim, H., & Korkmaz, M. (2018). Boron intake, osteocalcin polymorphism and serum level in postmenopausal osteoporosis. Journal of Trace Elements in Medicine and Biology48, 52-56. Abstract

Bunker, V. W. (1994). The role of nutrition in osteoporosis. British journal of biomedical science51(3), 228-240. Abstract

Devirian, T. A., & Volpe, S. L. (2003). The physiological effects of dietary boron. Article

Gaby, A. R. (1999). Natural treatments for osteoarthritis. Alternative Medicine Review4, 330-341. Article

Goldstein, M. C., & Goldstein, M. A. (2018). Vitamins and Minerals: Fact Versus Fiction. ABC-CLIO. BookP.4-5

Helliwell, T. R., Kelly, S. A., Walsh, H. P. J., Klenerman, L., Haines, J., Clark, R., & Roberts, N. B. (1996). Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthrosis. Bone18(2), 151-157. Abstract

Hunter, J. M., Nemzer, B. V., Rangavajla, N., Biţă, A., Rogoveanu, O. C., Neamţu, J., ... & Mogoşanu, G. D. (2019). The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review. Biological trace element research188(1), 11-25. Article

Jain, R., & Tiwari, A. (2019). Boron: A dietary mineral for human health. Apollo Medicine16(1), 66. Article

Khaliq, H., Juming, Z., & Ke-Mei, P. (2018). The physiological role of boron on health. Biological trace element research186(1), 31-51. Article

Lewiecki, E. M., Bilezikian, J. P., Carey, J. J., Dell, R. M., Gordon, C. M., Harris, S. T., ... & Rosenblatt, M. (2018). Proceedings of the 2017 Santa Fe Bone Symposium: insights and emerging concepts in the management of osteoporosis. Journal of Clinical Densitometry21(1), 3-21. Article

Lu, X., Li, K., Xie, Y., Qi, S., Shen, Q., Yu, J., ... & Zheng, X. (2019). Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects. Journal of Biomedical Materials Research Part A107(1), 12-24. Article

McCoy, H., Kenney, M. A., Montgomery, C., Irwin, A., Williams, L., & Orrell, R. (1994). Relation of boron to the composition and mechanical properties of bone. Environmental Health Perspectives102(suppl 7), 49-53. Article

Maslin, K., & Dennison, E. (2019). Diet and Bone Health. In Analysis in Nutrition Research (pp. 337-354). Academic Press. Chapter13

Meacham, S. L., Taper, L. J., & Volpe, S. L. (1994). Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes. Environmental health perspectives102(suppl 7), 79-82. Article

Miljkovic, D., Scorei, R. I., Cimpoiaşu, V. M., & Scorei, I. D. (2009). Calcium fructoborate: plant-based dietary boron for human nutrition. Journal of dietary supplements6(3), 211-226. Article

Moustafa, S. R. (2019). Relationship of some ultra trace elements with atherosclerosis. Zanco Journal of Medical Sciences (Zanco J Med Sci)23(1), 66-73. Article

Morelli, V., Naquin, C., & Weaver, V. (2003). Alternative therapies for traditional disease states: osteoarthritis. American Family Physician67(2), 339-346. Article

Newnham, R. E. (2002). How boron is being used in medical practice. In Boron in plant and animal nutrition (pp. 59-62). Springer, Boston, MA. Abstract

Newnham, R.E. (1994). Essentiality of boron for health bones and joints. Environmental health perspective, 102 (suppl 7), 83-85. Article

Nielsen, F. H. (2014). Update on human health effects of boron. Journal of Trace Elements in Medicine and Biology28(4), 383-387. Abstract

Nielsen, F. H. (2008). Is boron nutritionally relevant?. Nutrition reviews66(4), 183-191. Article

Nielsen, F. H. (1990). Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones [electronic resource]. Magnesium and trace elements9(2), 61. Article

Nielsen, F. H., Hunt, C. D., Mullen, L. M., & Hunt, J. R. (1987). Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. The FASEB journal1(5), 394-397. Article 

Pietrzkowski, Z., Mercado-Sesma, A. R., Argumedo, R., Cervantes, M., Nemzer, B., & Reyes-Izquierdo, T. (2018). Effects of once-daily versus twice daily dosing of calcium fructoborate on knee discomfort. A 90 day, double-blind, placebo controlled randomized clinical study. J Aging Res Clin Pract7(1), 31-36. Article

Pizzorno, L. (2015). Nothing boring about boron. Integrative Medicine: A Clinician's Journal14(4), 35. Article

Prejac, J., Skalny, A. A., Grabeklis, A. R., Uzun, S., Mimica, N., & Momčilović, B. (2018). Assessing the boron nutritional status by analyzing its cummulative frequency distribution in the hair and whole blood. Journal of Trace Elements in Medicine and Biology45, 50-56. Article

Price, C. T., Langford, J. R., & Liporace, F. A. (2012). Essential nutrients for bone health and a review of their availability in the average North American diet. The open orthopaedics journal6, 143. Article

Rico, H. (1991). Minerals and osteoporosis. Osteoporosis International2(1), 20-25. Review

Scorei, R., Mitrut, P., Petrisor, I., & Scorei, I. (2011). A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis. Biological trace element research144(1-3), 253-263. Article

Travers, R. L., Rennie, G. C., & Newnham, R. E. (1990). Boron and arthritis: the results of a double-blind pilot study. Journal of Nutritional Medicine1(2), 127-132. Abstract

Volpe, S. L., Taper, L. J., & Meacham, S. (1993). The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnesium research6(3), 291-296. Abstract

Zhang, J. (2018). Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis. BMC musculoskeletal disorders19(1), 22. Article

Brain, Heart, Lung & Breast Health

Altinoz, M. A., Topcu, G., & Elmaci, İ. (2019). Boron’s neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment. International Journal of Neuroscience, 1-15. Article

Bakirdere, S., Orenay, S., & Korkmaz, M. (2010). Effect of boron on human health. The Open Mineral Processing Journal3(1). Article

Cui, Y., Winton, M. I., Zhang, Z. F., Rainey, C., Marshall, J., De Kernion, J. B., & Eckhert, C. D. (2004). Dietary boron intake and prostate cancer risk. Oncology reports11(4), 887-892. Article

Donoiu, I., Militaru, C., Obleagă, O., Hunter, J. M., Neamţu, J., Biţă, A., ... & Rogoveanu, O. C. (2018).Effects of Boron-Containing Compounds on Cardiovascular Disease Risk Factors–A Review. Journal of Trace Elements in Medicine and Biology. Article

Gaby, A. R., & Wright, J. V. (1990). Nutrients and osteoporosis. Journal of Nutritional Medicine1(1), 63-72. Article

Kuru, R., Yilmaz, S., Balan, G., Tuzuner, B. A., Tasli, P. N., Akyuz, S., ... & Sahin, F. (2019). Boron-rich diet may regulate blood lipid profile and prevent obesity: A non-drug and self-controlled clinical trial. Journal of Trace Elements in Medicine and Biology54, 191-198. Abstract

Penland, J. G. (1994). Dietary boron, brain function, and cognitive performance. Environmental health perspectives102(suppl 7), 65-72. Article

Ozdemir, H., Yaren, B., & Oto, G. (2019). Effect of dietary boron on learning and behavior in rats administered with boric acid. Cell Mol Biol (Noisy le Grand)65(1). Article

Scorei, I. R. (2011). Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy. Front Biosci (Schol Ed)3, 205-215. Article

Scorei, R., Ciubar, R., Ciofrangeanu, C. M., Mitran, V., Cimpean, A., & Iordachescu, D. (2008). Comparative effects of boric acid and calcium fructoborate on breast cancer cells. Biological trace element research122(3), 197-205. Abstract

Simsek, F., Inan, S., & Korkmaz, M. (2019). An in Vitro Study in Which New Boron Derivatives Maybe an Option for Breast Cancer Treatment. breast cancer13, 14. Article

Vijay Bhasker, T., Gowda, N. K. S., Krishnamoorthy, P., Pal, D. T., Sejian, V., Awachat, V. B., & Verma, A. K. (2017). Boron supplementation provides hepato-protective effect and improves performance in Wistar rats fed calcium deficit diet. Indian J Anim Sci87(10), 1213-1218. Article

Anti-inflammatory & Longevity

Acaroz, U., Ince, S., Arslan-Acaroz, D., Gurler, Z., Kucukkurt, I., Demirel, H. H., ... & Zhu, K. (2018). The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats. Food and chemical toxicology118, 745-752. Abstract

Nielsen, F. H. (2018). Boron in Aging and Longevity. In Trace Elements and Minerals in Health and Longevity (pp. 163-177). Springer, Cham. Abstract

Scorei, R. I., & Rotaru, P. (2011). Calcium fructoborate—potential anti-inflammatory agent. Biological trace element research143(3), 1223-1238. Article

Scorei, R. I., Ciofrangeanu, C., Ion, R., Cimpean, A., Galateanu, B., Mitran, V., & Iordachescu, D. (2010). In vitro effects of calcium fructoborate upon poduction of inflammatory mediators by LPS-stimulated RAW 264.7 macrophages. Biological trace element research135(1-3), 334-344. Article

Scorei, R., Ciubar, R., Iancu, C., Mitran, V., Cimpean, A., & Iordachescu, D. (2007). In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes. Biological trace element research118(1), 27-37. Article

Scorei, R., Cimpoiasu, V. M., & Iordachescu, D. (2005). In vitro evaluation of the antioxidant activity of calcium fructoborate. Biological trace element research107(2), 127-134. Abstract

Boron and Polyphenols: Fructo Borate in No 7 Systemic Booster (or with High ORAC)

Arjmandi, B. H., Johnson, C. D., Campbell, S. C., Hooshmand, S., Chai, S. C., & Akhter, M. P. (2010). Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. Journal of medicinal food13(2), 312-319. Abstract  [High ORAC]

Austermann, K., Baecker, N., Stehle, P., & Heer, M. (2019). Putative Effects of Nutritive Polyphenols on Bone Metabolism In Vivo—Evidence from Human Studies. Nutrients11(4), 871. Article

Basu, S., Michaëlsson, K., Olofsson, H., Johansson, S., & Melhus, H. (2001). Association between oxidative stress and bone mineral density. Biochemical and biophysical research communications288(1), 275-279. Abstract

Brondani, J. E., Comim, F. V., Flores, L. M., Martini, L. A., & Premaor, M. O. (2019). Fruit and vegetable intake and bones: A systematic review and meta-analysis. PloS one14(5), e0217223. Article

Domazetovic, V., Marcucci, G., Pierucci, F., Bruno, G., Di Cesare Mannelli, L., Ghelardini, C., ... & Vincenzini, M. T. (2019). Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT 1. FEBS open bio. Article

Garrett, I. R., Boyce, B. F., Oreffo, R. O., Bonewald, L., Poser, J., & Mundy, G. R. (1990). Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. The Journal of clinical investigation85(3), 632-639. Article

Hardcastle, A. C., Aucott, L., Reid, D. M., & Macdonald, H. M. (2011). Associations between dietary flavonoid intakes and bone health in a Scottish population. Journal of Bone and Mineral Research26(5), 941-947. Article

Hubert, P., Lee, S., Lee, S. K., & Chun, O. (2014). Dietary polyphenols, berries, and age-related bone loss: A review based on human, animal, and cell studies. Antioxidants3(1), 144-158. Article

Koch, W. (2019). Dietary Polyphenols—Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review. Nutrients11(5), 1039. Article

Lobene, A. J., McCabe, L. D., Stone, M. S., Kindler, J. M., Bailey, R. L., Moshfegh, A. J., ... & Weaver, C. M. (2019). Dietary Mineral Intake Ratios and Bone Health in Adults. In Nutritional Influences on Bone Health (pp. 53-67). Springer, Cham. Abstract

New, S. A., Robins, S. P., Campbell, M. K., Martin, J. C., Garton, M. J., Bolton-Smith, C., ... & Reid, D. M. (2000). Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?. The American journal of clinical nutrition71(1), 142-151. Article

Welch, A., MacGregor, A., Jennings, A., Fairweather‐Tait, S., Spector, T., & Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. Journal of Bone and Mineral Research27(9), 1872-1878. Article

Welch, A. A., & Hardcastle, A. C. (2014). The effects of flavonoids on bone. Current osteoporosis reports12(2), 205-210. Abstract

Welch, A., MacGregor, A., Jennings, A., Fairweather‐Tait, S., Spector, T., & Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. Journal of Bone and Mineral Research27(9), 1872-1878. Article

Weitzmann, M. N. (2013). The role of inflammatory cytokines, the RANKL/OPG axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis. Scientifica2013. Article

Yahia, E. M., García-Solís, P., & Celis, M. E. M. (2019). Contribution of Fruits and Vegetables to Human Nutrition and Health. In Postharvest Physiology and Biochemistry of Fruits and Vegetables (pp. 19-45). Woodhead Publishing. Abstract

Zhang, Z. Q., He, L. P., Liu, Y. H., Liu, J., Su, Y. X., & Chen, Y. M. (2014). Association between dietary intake of flavonoid and bone mineral density in middle aged and elderly Chinese women and men. Osteoporosis International25(10), 2417-2425. Abstract

Ingredients

One capsule contains:
Vitamin C (from Calcium Ascorbate)  234mg    400%DV
Calcium (from Calcium Ascorbate)  26mg     3%DV
Fructo Borate Complex (yields 6mg elemental Boron)  240mg 

Other Ingredients:  Cellulose &water (capsule shell).


Protocol

FRUCTO BORATE — The Fructo Borate is designed to reduce osteoarthritis’ joint pain and swelling, and increase joint mobility.*

Anti-inflammation and reduction of joint pain: Clinical trials suggest 1-2 capsules twice a day.*

Bone health: Fructo Borate helps to re-mineralize and strengthen bones, increases absorption of vitamin D, calcium, and magnesium. Take 1-2 caps a day.*

Heart health: Boron is shown to lower C-reactive proteins (marker for cardiovascular disease). Take 1-2 caps a day.*

Lung & immune support: Take 1-2 caps a day as anti-inflammatory for lung congestion (can take up to 6 a day for 2 days, reduce to 2-4 caps a day). Take 1-2 caps at the onset of a cold or flu.*

Our favorite: The master mineral, boron, in the Fructo Borate is in command of so many functions in the body. We add it to many of our protocols to enhance healing. Since Frcuto Borate mimics the boron in foods, it is exceptionally available.*

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