Fructo Borate Complex

 

 

New form of boron supplementation that is the exact molecular structure of dietary boron found in fruits, vegetables and nuts. US Patent #US 5962049 A. Fructo Borate 240 mg with calcium ascorbate 260 mg provides 6 mg of elemental boron. No excipients. 60 capsules per bottle. 500 mg per vegetarian capsule.

• Patented Technology creates a highly effective Fructo Borate molecule.
• 240mg fructoborate and 260mg calcium ascorbate per vegetarian capsule.
• Each capsule supplies 6mg of elemental boron.
• New form of boron supplementation: US patented carbohydrate bound boron.
• Exact duplicate of dietary boron found in fruits, vegetables and nuts.
• Association Constant high: Receptor sites receive entire molecule.
• Osteoporosis: Reduces excretion of Mg and Ca, re-mineralizes bone.
• Use therapeutically against osteoarthritis: Reduces pain and swelling and increases mobility.
• Down-regulates immune system: Reduces over-reactive neutrophil levels.
• Anti-oxidant: Increases SOD and Catalase production.
• Anti-aging: Increases Vitamin D and Steroid hormone levels in the blood.
• Anti-cancer: Reduces PSA marker for prostate cancer.
• Clinical trial: 1 to 2 capsules BID to reduce pain and regenerate bone; 1 capsule daily for maintenance. Observed results period is from 2-8 weeks.
• No filler, flowing agents or excipients of any kind.

Research

 

FOOD SCIENCE: THE APPLICATION AND USE OF Fructo Borate [plant-based Dietary boron].*

Arthritis and Osteoporosis: Bone and Joint Health

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Bartl, R., & Bartl, C. (2019). A Step-by-Step Programme for Healthy Bones. In The Osteoporosis Manual (pp. 137-150). Springer, Cham. Abstract

Beattie, J. H., & Peace, H. S. (1993). The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. British journal of nutrition, 69(3), 871-884. Article

Boyacioglu, O., Orenay-Boyacioglu, S., Yildirim, H., & Korkmaz, M. (2018). Boron intake, osteocalcin polymorphism and serum level in postmenopausal osteoporosis. Journal of Trace Elements in Medicine and Biology, 48, 52-56. Abstract

Bunker, V. W. (1994). The role of nutrition in osteoporosis. British journal of biomedical science, 51(3), 228-240. Abstract

Devirian, T. A., & Volpe, S. L. (2003). The physiological effects of dietary boron. Article

Gaby, A. R. (1999). Natural treatments for osteoarthritis. Alternative Medicine Review, 4, 330-341. Article

Goldstein, M. C., & Goldstein, M. A. (2018). Vitamins and Minerals: Fact Versus Fiction. ABC-CLIO. BookP.4-5

Helliwell, T. R., Kelly, S. A., Walsh, H. P. J., Klenerman, L., Haines, J., Clark, R., & Roberts, N. B. (1996). Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthrosis. Bone, 18(2), 151-157. Abstract

Hunter, J. M., Nemzer, B. V., Rangavajla, N., Biţă, A., Rogoveanu, O. C., Neamţu, J., ... & Mogoşanu, G. D. (2019). The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review. Biological trace element research, 188(1), 11-25. Article

Jain, R., & Tiwari, A. (2019). Boron: A dietary mineral for human health. Apollo Medicine, 16(1), 66. Article

Khaliq, H., Juming, Z., & Ke-Mei, P. (2018). The physiological role of boron on health. Biological trace element research, 186(1), 31-51. Article

Lewiecki, E. M., Bilezikian, J. P., Carey, J. J., Dell, R. M., Gordon, C. M., Harris, S. T., ... & Rosenblatt, M. (2018). Proceedings of the 2017 Santa Fe Bone Symposium: insights and emerging concepts in the management of osteoporosis. Journal of Clinical Densitometry, 21(1), 3-21. Article

Lu, X., Li, K., Xie, Y., Qi, S., Shen, Q., Yu, J., ... & Zheng, X. (2019). Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects. Journal of Biomedical Materials Research Part A, 107(1), 12-24. Article

McCoy, H., Kenney, M. A., Montgomery, C., Irwin, A., Williams, L., & Orrell, R. (1994). Relation of boron to the composition and mechanical properties of bone. Environmental Health Perspectives, 102(suppl 7), 49-53. Article

Maslin, K., & Dennison, E. (2019). Diet and Bone Health. In Analysis in Nutrition Research (pp. 337-354). Academic Press. Chapter13

Meacham, S. L., Taper, L. J., & Volpe, S. L. (1994). Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes. Environmental health perspectives, 102(suppl 7), 79-82. Article

Miljkovic, D., Scorei, R. I., Cimpoiaşu, V. M., & Scorei, I. D. (2009). Calcium fructoborate: plant-based dietary boron for human nutrition. Journal of dietary supplements, 6(3), 211-226. Article

Moustafa, S. R. (2019). Relationship of some ultra trace elements with atherosclerosis. Zanco Journal of Medical Sciences (Zanco J Med Sci), 23(1), 66-73. Article

Morelli, V., Naquin, C., & Weaver, V. (2003). Alternative therapies for traditional disease states: osteoarthritis. American Family Physician, 67(2), 339-346. Article

Newnham, R. E. (2002). How boron is being used in medical practice. In Boron in plant and animal nutrition (pp. 59-62). Springer, Boston, MA. Abstract

Newnham, R.E. (1994). Essentiality of boron for health bones and joints. Environmental health perspective, 102 (suppl 7), 83-85. Article

Nielsen, F. H. (2014). Update on human health effects of boron. Journal of Trace Elements in Medicine and Biology, 28(4), 383-387. Abstract

Nielsen, F. H. (2008). Is boron nutritionally relevant?. Nutrition reviews, 66(4), 183-191. Article

Nielsen, F. H. (1990). Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones [electronic resource]. Magnesium and trace elements, 9(2), 61. Article

Nielsen, F. H., Hunt, C. D., Mullen, L. M., & Hunt, J. R. (1987). Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. The FASEB journal, 1(5), 394-397. Article 

Pietrzkowski, Z., Mercado-Sesma, A. R., Argumedo, R., Cervantes, M., Nemzer, B., & Reyes-Izquierdo, T. (2018). Effects of once-daily versus twice daily dosing of calcium fructoborate on knee discomfort. A 90 day, double-blind, placebo controlled randomized clinical study. J Aging Res Clin Pract, 7(1), 31-36. Article

Pizzorno, L. (2015). Nothing boring about boron. Integrative Medicine: A Clinician's Journal, 14(4), 35. Article

Prejac, J., Skalny, A. A., Grabeklis, A. R., Uzun, S., Mimica, N., & Momčilović, B. (2018). Assessing the boron nutritional status by analyzing its cummulative frequency distribution in the hair and whole blood. Journal of Trace Elements in Medicine and Biology, 45, 50-56. Article

Price, C. T., Langford, J. R., & Liporace, F. A. (2012). Essential nutrients for bone health and a review of their availability in the average North American diet. The open orthopaedics journal, 6, 143. Article

Rico, H. (1991). Minerals and osteoporosis. Osteoporosis International, 2(1), 20-25. Review

Scorei, R., Mitrut, P., Petrisor, I., & Scorei, I. (2011). A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis. Biological trace element research, 144(1-3), 253-263. Article

Travers, R. L., Rennie, G. C., & Newnham, R. E. (1990). Boron and arthritis: the results of a double-blind pilot study. Journal of Nutritional Medicine, 1(2), 127-132. Abstract

Volpe, S. L., Taper, L. J., & Meacham, S. (1993). The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnesium research, 6(3), 291-296. Abstract

Zhang, J. (2018). Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis. BMC musculoskeletal disorders, 19(1), 22. Article

Brain, Heart, Lung & Breast Health

Altinoz, M. A., Topcu, G., & Elmaci, İ. (2019). Boron’s neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment. International Journal of Neuroscience, 1-15. Article

Bakirdere, S., Orenay, S., & Korkmaz, M. (2010). Effect of boron on human health. The Open Mineral Processing Journal, 3(1). Article

Cui, Y., Winton, M. I., Zhang, Z. F., Rainey, C., Marshall, J., De Kernion, J. B., & Eckhert, C. D. (2004). Dietary boron intake and prostate cancer risk. Oncology reports, 11(4), 887-892. Article

Donoiu, I., Militaru, C., Obleagă, O., Hunter, J. M., Neamţu, J., Biţă, A., ... & Rogoveanu, O. C. (2018).Effects of Boron-Containing Compounds on Cardiovascular Disease Risk Factors–A Review. Journal of Trace Elements in Medicine and Biology. Article

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Kuru, R., Yilmaz, S., Balan, G., Tuzuner, B. A., Tasli, P. N., Akyuz, S., ... & Sahin, F. (2019). Boron-rich diet may regulate blood lipid profile and prevent obesity: A non-drug and self-controlled clinical trial. Journal of Trace Elements in Medicine and Biology, 54, 191-198. Abstract

Penland, J. G. (1994). Dietary boron, brain function, and cognitive performance. Environmental health perspectives, 102(suppl 7), 65-72. Article

Ozdemir, H., Yaren, B., & Oto, G. (2019). Effect of dietary boron on learning and behavior in rats administered with boric acid. Cell Mol Biol (Noisy le Grand), 65(1). Article

Scorei, I. R. (2011). Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy. Front Biosci (Schol Ed), 3, 205-215. Article

Scorei, R., Ciubar, R., Ciofrangeanu, C. M., Mitran, V., Cimpean, A., & Iordachescu, D. (2008). Comparative effects of boric acid and calcium fructoborate on breast cancer cells. Biological trace element research, 122(3), 197-205. Abstract

Simsek, F., Inan, S., & Korkmaz, M. (2019). An in Vitro Study in Which New Boron Derivatives Maybe an Option for Breast Cancer Treatment. breast cancer, 13, 14. Article

Vijay Bhasker, T., Gowda, N. K. S., Krishnamoorthy, P., Pal, D. T., Sejian, V., Awachat, V. B., & Verma, A. K. (2017). Boron supplementation provides hepato-protective effect and improves performance in Wistar rats fed calcium deficit diet. Indian J Anim Sci, 87(10), 1213-1218. Article

Anti-inflammatory & Longevity

Acaroz, U., Ince, S., Arslan-Acaroz, D., Gurler, Z., Kucukkurt, I., Demirel, H. H., ... & Zhu, K. (2018). The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats. Food and chemical toxicology, 118, 745-752. Abstract

Nielsen, F. H. (2018). Boron in Aging and Longevity. In Trace Elements and Minerals in Health and Longevity (pp. 163-177). Springer, Cham. Abstract

Scorei, R. I., & Rotaru, P. (2011). Calcium fructoborate—potential anti-inflammatory agent. Biological trace element research, 143(3), 1223-1238. Article

Scorei, R. I., Ciofrangeanu, C., Ion, R., Cimpean, A., Galateanu, B., Mitran, V., & Iordachescu, D. (2010). In vitro effects of calcium fructoborate upon poduction of inflammatory mediators by LPS-stimulated RAW 264.7 macrophages. Biological trace element research, 135(1-3), 334-344. Article

Scorei, R., Ciubar, R., Iancu, C., Mitran, V., Cimpean, A., & Iordachescu, D. (2007). In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes. Biological trace element research, 118(1), 27-37. Article

Scorei, R., Cimpoiasu, V. M., & Iordachescu, D. (2005). In vitro evaluation of the antioxidant activity of calcium fructoborate. Biological trace element research, 107(2), 127-134. Abstract

Boron and Polyphenols: Fructo Borate in No 7 Systemic Booster (or with High ORAC)

Arjmandi, B. H., Johnson, C. D., Campbell, S. C., Hooshmand, S., Chai, S. C., & Akhter, M. P. (2010). Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. Journal of medicinal food, 13(2), 312-319. Abstract  [High ORAC]

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Basu, S., Michaëlsson, K., Olofsson, H., Johansson, S., & Melhus, H. (2001). Association between oxidative stress and bone mineral density. Biochemical and biophysical research communications, 288(1), 275-279. Abstract

Brondani, J. E., Comim, F. V., Flores, L. M., Martini, L. A., & Premaor, M. O. (2019). Fruit and vegetable intake and bones: A systematic review and meta-analysis. PloS one, 14(5), e0217223. Article

Domazetovic, V., Marcucci, G., Pierucci, F., Bruno, G., Di Cesare Mannelli, L., Ghelardini, C., ... & Vincenzini, M. T. (2019). Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT 1. FEBS open bio. Article

Garrett, I. R., Boyce, B. F., Oreffo, R. O., Bonewald, L., Poser, J., & Mundy, G. R. (1990). Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. The Journal of clinical investigation, 85(3), 632-639. Article

Hardcastle, A. C., Aucott, L., Reid, D. M., & Macdonald, H. M. (2011). Associations between dietary flavonoid intakes and bone health in a Scottish population. Journal of Bone and Mineral Research, 26(5), 941-947. Article

Hubert, P., Lee, S., Lee, S. K., & Chun, O. (2014). Dietary polyphenols, berries, and age-related bone loss: A review based on human, animal, and cell studies. Antioxidants, 3(1), 144-158. Article

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Welch, A., MacGregor, A., Jennings, A., Fairweather‐Tait, S., Spector, T., & Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. Journal of Bone and Mineral Research, 27(9), 1872-1878. Article

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