Activating GLP-1: Appetite Suppression and Blood Glucose Regulation

I ran across an article that discusses the Ozempic drug for weight loss. The drug delivers a molecule that mimics the GLP-1 hormone to suppress the appetite and to help insulin to manage blood sugar levels.

All excellent for weight loss. Can we do it naturally, though, with food?

Yes!  And there is plenty of research to show us that food is a powerful choice to suppress the appetite and manage blood glucose. Check out the references below.

The process of activating GLP-1 occurs naturally with particular foods, and of course, our favorites are the polyphenols, ancient seeds, such as buckwheat, and plant fibers to stimulate the microbiome to produce more short chain fatty acids, signaling for more GLP-1. 

Greens, seeds, berries, broccoli, apples, artichoke - colorful polyphenols and fiber rich foods. Incorporate to your diet, and enjoy! 

Buckwheat in Staff of Life, alongside other ancient seeds for fiber: microbiome health, more short-chain fatty acids, and an easement in metabolic regulation.

Enjoy!

Yours as Always, 

Dohrea Bardell, PhD

References

• Bodnaruc, A. M., Prud’homme, D., Blanchet, R., & Giroux, I. (2016). Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review. Nutrition & metabolism, 13(1), 92.
• Chan-Zapata, I., Sandoval-Castro, C., & Segura-Campos, M. R. (2022). Proteins and peptides from vegetable food sources as therapeutic adjuvants for the type 2 diabetes mellitus. Critical reviews in food science and nutrition, 62(10), 2673-2682.
• Johnson, M. H., & De Mejia, E. G. (2016). Phenolic compounds from fermented berry beverages modulated gene and protein expression to increase insulin secretion from pancreatic β-cells in vitro. Journal of Agricultural and Food Chemistry, 64(12), 2569-2581.
• Lee, L. C., Hou, Y. C., Hsieh, Y. Y., Chen, Y. H., Shen, Y. C., Lee, I. J., ... & Liu, H. K. (2021). Dietary supplementation of rutin and rutin-rich buckwheat elevates endogenous glucagon-like peptide 1 levels to facilitate glycemic control in type 2 diabetic mice. Journal of Functional Foods, 85, 104653.
• Nunn, L. (2023). The satiating potential of plant proteins transiting the upper gut.
• Stringer, D. M., Taylor, C. G., Appah, P., Blewett, H., & Zahradka, P. (2013). Consumption of buckwheat modulates the post-prandial response of selected gastrointestinal satiety hormones in individuals with type 2 diabetes mellitus. Metabolism, 62(7), 1021-1031.
• Stote, K., Corkum, A., Sweeney, M., Shakerley, N., Kean, T., & Gottschall-Pass, K. (2019). Postprandial effects of blueberry (Vaccinium angustifolium) consumption on glucose metabolism, gastrointestinal hormone response, and perceived appetite in healthy adults: a randomized, placebo-controlled crossover trial. Nutrients, 11(1), 202.
• Törrönen, R., Sarkkinen, E., Niskanen, T., Tapola, N., Kilpi, K., & Niskanen, L. (2012). Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects. British journal of nutrition, 107(10), 1445-1451.
• Tsuda, T. (2016). Recent progress in anti-obesity and anti-diabetes effect of berries. Antioxidants, 5(2), 13.
• Zaharudin, N., Tullin, M., Pekmez, C. T., Sloth, J. J., Rasmussen, R. R., & Dragsted, L. O. (2021). Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans–A randomized, 3-way, blinded, cross-over meal study. Clinical Nutrition, 40(3), 830-838.