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A Super Hero Probiotic: Supernatant

Supernatant Synbiotic Formula has naturally occurring whole probiotic organisms with their Supernatant metabolites and microRNA (ORNs - Oligoribonucleotides), very important nutrients and factors that help protect and balance the gut microbiota.

Supernatant is referred to as the fermented “soup” that contains powerful probiotic metabolites: enzymes, such as bile hydrolase, lactase, and others, peptides, proteins, vitamins, short chain fatty acids, bacteriocins, biosurfactants, microRNA or ORNs, and other nutritional substances. Supernatant and microRNAs are the power behind the new emerging research on immune-biotics: the antimicrobial qualities exerted by probiotics and their metabolites (Arena et al., 2018).

The super blend includes: Probiotics-Bifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus, Streptococcus thermophilusPrebiotics- Inulin from Chicory root; Supernatant - a nutritional metabolites “soup” that is created from each of the probiotic organisms, which include their lactic acid, enzymes, vitamins, short-chain fatty acids, bacteriocins, bio-surfactants, bile salt hydrolase, and their ORNs (Oligoribonucleotides; microRNA). The supernatant is freeze-dried along with the good bacteria to form a powerful antimicrobial formula. 

Supernatant Synbiotic Formula


  • Aguilar, C., Mano, M., & Eulalio, A. (2018). MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense. Trends in microbiologyAbstract
  • Aguilar-Toalá, J. E., Garcia-Varela, R., Garcia, H. S., Mata-Haro, V., González-Córdova, A. F., Vallejo-Cordoba, B., & Hernández-Mendoza, A. (2018). Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology75, 105-114. Abstract
  • Albarracin, L., Kobayashi, H., Iida, H., Sato, N., Nochi, T., Aso, H., ... & Villena, J. (2017). Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli. Frontiers in immunology8, 57. Article
  • Arena, M. P., Capozzi, V., Russo, P., Drider, D., Spano, G., & Fiocco, D. (2018). Immunobiosis and probiosis: antimicrobial activity of lactic acid bacteria with a focus on their antiviral and antifungal properties. Applied microbiology and biotechnology102(23), 9949-9958Abstract
  • Carvalho, R. D., do Carmo, F. L., de Oliveira Junior, A., Langella, P., Chatel, J. M., Bermúdez-Humarán, L. G., ... & de Azevedo, M. S. (2017). Use of wild type or recombinant lactic acid bacteria as an alternative treatment for gastrointestinal inflammatory diseases: a focus on inflammatory bowel diseases and mucositis. Frontiers in microbiology8, 800. 
  • Cotter, P. D., Ross, R. P., & Hill, C. (2013). Bacteriocins—a viable alternative to antibiotics? Nature Reviews Microbiology11(2), 95. Abstract
  • Cotter, P. D., Hill, C., & Ross, R. P. (2005). Food microbiology: bacteriocins: developing innate immunity for food. Nature Reviews Microbiology3(10), 777. Abstract
  • Goldenberg, J. Z., Ma, S. S., Saxton, J. D., Martzen, M. R., Vandvik, P. O., Thorlund, K., ... & Johnston, B. C. (2013). Probiotics for the prevention of Clostridium difficile‐associated diarrhea in adults and children. Cochrane Database of Systematic Reviews, (5). Abstract
  • Górska, S., Dylus, E., Rudawska, A., Brzozowska, E., Srutkova, D., Schwarzer, M., ... & Gamian, A. (2016). Immunoreactive proteins of Bifidobacterium longum ssp. longum CCM 7952 and Bifidobacterium longum ssp. longum CCDM 372 Identified by gnotobiotic mono-colonized mice sera, immune rabbit sera and non-immune human sera. Frontiers in microbiology7, 1537. Article 

To your health,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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