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Supernatant Part II: A Probiotic Like No Other

What is the Supernatant and how do we use it for difficult to treat conditions?

Supernatant  is the fermented medium created during the culturing process of probiotics. Supernatant is the fermented “soup” that contains important probiotic metabolites, such as enzymes, peptides, proteins, vitamins, short chain fatty acids, and other nutrients and factors, including antimicrobials such as Bacteriocins that may be used as a possible alternative to antibiotics (Cotter, Ross, & Hill, 2013; Yang et al., 2014).

Supernatant , or as some call it, “postbiotic” (Auilar-Toalá et al., 2018), or “parabiotic” (Choudhury & Kamilya, 2018), is shown in research to have powerful antimicrobial properties with the potential to block adhesion, invasion and translocation of E. coli, yet it is gentle enough to be used to ‘enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense’ (He et al., 2017).

In fact, Lazar et al.’s (2009) in vitro study concluded that the soluble probiotic metabolites, or supernatant, might actually interfere with the beginning stages of adherence and colonization of selected E. coli. This means that the supernatant itself exudes protective effects (Lazar et al., 2009), as well as work synergistically with probiotic organisms to stimulate the immune system against pathogenic invasion (Ditu et al., 2014).

How do we use it? 

There is so much written scientific literature on the Supernatant. Let's take a look at: 

Immunobiotics:  The combination of lactic acid bacteria (LAB) and their metabolites is given much consideration as a method to improve human immune response against viral and fungal overgrowth. The term “immunobiotic” is a relatively new way to describe the antimicrobial qualities exerted by probiotics and their metabolites (Arena et al., 2018).

The term ‘immunobiotic’ has been proposed to define beneficial microbes with the ability to regulate the immune system and lower inflammation of the gut tissue (Villena & Kitazawa, 2017; Villena et al., 2016). For example, the probiotics L. rhamnosus and L. plantarum carry immunobiotic properties and are shown to increase protection against viral intestinal infections (Albarracin et al., 2017). In a different study on mice, Kikuchi et al. (2014) discovered that oral administration of L. plantarum enhanced IgA secretion in both intestine and lung tissues, supporting against influenza virus infection. Immunobiotics, the combination of probiotics and their supernatant metabolites, have been found to support and benefit respiratory immunity (Zelaya et al., 2016), modulate mucosal cytokine profiles, IgA levels, and more, in various conditions of gastrointestinal inflammation (Carvalho et al., 2017).

Use: 1-2 Capsules for daily use. Check out the protocols or email us at



Yours as Always, 



  • Albarracin, L., Kobayashi, H., Iida, H., Sato, N., Nochi, T., Aso, H., ... & Villena, J. (2017). Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli. Frontiers in immunology8, 57. Article
  • Arena, M. P., Capozzi, V., Russo, P., Drider, D., Spano, G., & Fiocco, D. (2018). Immunobiosis and probiosis: antimicrobial activity of lactic acid bacteria with a focus on their antiviral and antifungal properties. Applied microbiology and biotechnology102(23), 9949-9958. Abstract
  • Carvalho, R. D., do Carmo, F. L., de Oliveira Junior, A., Langella, P., Chatel, J. M., Bermúdez-Humarán, L. G., ... & de Azevedo, M. S. (2017). Use of wild type or recombinant lactic acid bacteria as an alternative treatment for gastrointestinal inflammatory diseases: a focus on inflammatory bowel diseases and mucositis. Frontiers in microbiology8, 800. Article
  • Kikuchi, Y., Kunitoh-Asari, A., Hayakawa, K., Imai, S., Kasuya, K., Abe, K., ... & Hachimura, S. (2014). Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice. PloS one9(1), e86416. Article
  • Villena, J., Vizoso-Pinto, M. G., & Kitazawa, H. (2016). Intestinal innate antiviral immunity and immunobiotics: beneficial effects against rotavirus infection. Frontiers in immunology7, 230437.
  • Villena, J., & Kitazawa, H. (2017). Probiotic microorganisms: a closer look. Microorganisms5(2), 17.
  •  Zelaya, H., Alvarez, S., Kitazawa, H., & Villena, J. (2016). Respiratory antiviral immunity and immunobiotics: beneficial effects on inflammation-coagulation interaction during influenza virus infection. Frontiers in immunology7, 230440.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

My Research: Peace

Globe_Home 3Immanuel Kant's What is Enlightenment? has a particular paragraph that has always managed to make me happy: But that the public should enlighten itself is more likely; indeed, if it is only allowed freedom, enlightenment is almost inevitable. For even among the entrenched guardians of the great masses a few will always think for themselves, a few who, after having themselves thrown off the yoke of immaturity, will spread the spirit of a rational appreciation for both their own worth and for each person’s calling to think for himself.

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