Energy is Back!

The more I research the ingredients in Energy, the more I am amazed at its power to regenerate our internal mechanism for energy production. 

We learned the centrality of AMPK - an activating mechanism that is in command of the energy in every cell in your body.

AMPK is AMP-activated protein kinase or 5' adenosine monophosphate-activates protein kinase. An enzyme that is a switch of a sort, or an energy sensor (Hardie et al., 2012). It is responsible for the activation of ATP - the energy source in every cell.

How do we make sure that we have plenty of AMPK?  Research points toward the importance of polyphenols and its effect on AMPK and health of liver, kidneys, energy, weight loss, metabolism, and heart health. It is truly astonishing. (Li et al., 2023; Sotoudeheian & Hoseini, 2023; Xu et al., 2023;  Zang et al., 2006)

The combination of polyphenols and probiotics for the microbiome both maintain a good functioning AMPK (Li et al., 2024). 

We at first thought of Energy for exercise (endurance and strength) as the combination of ultra-minerals and apple extracts significantly boosted the body’s ability to exercise longer and harder.

The trials utilized a 150mg dosage of the mix and showed blood ATP increased by 40% at 60 minutes following ingestion and dropped 28% at 120 minutes following ingestion. Muscle biopsy was also performed to show an 281% increase of ATP levels in muscle tissue at 60 minutes, and 433% at 120 minutes following ingestion (Reyes-Izquirdo et al., 2014).

And there is more. 

Ultra (or trace) minerals are essential nutrients for human health (Davidson, 2017), playing a central role in regulating cardiovascular function (Mohammadifard et al., 2017), metabolic functions, internal antioxidant defense mechanism, bone formation, immune function, and much more (Pappas et al., 2018). 

Energy

Yours as always,

Dohrea 

References

• • Canbolat, E., & Cakıroglu, F. P. (2023). The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review. Critical Reviews in Food Science and Nutrition, 63(4), 449-456. Abstract
  • Davison, K. M. (2017). Mineral Nutrients: From Macro-Level to Ultra Trace. In Nutrition Guide for Physicians and Related Healthcare Professionals (pp. 261-272). Humana Press, Cham.
  • Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012). AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature reviews Molecular cell biology, 13(4), 251-262. Article
  • Jordan, A. N., Jurca, R., Abraham, E. H., Salikhova, A., Mann, J. K., Morss, G. M., ... & Earnest, C. P. (2004). Effects of oral ATP supplementation on anaerobic power and muscular strength. Medicine & Science in Sports & Exercise, 36(6), 983-990.
  • Fang, C., Pan, J., Qu, N., Lei, Y., Han, J., Zhang, J., & Han, D. (2022). The AMPK pathway in fatty liver disease. Frontiers in Physiology, 13, 970292. Article
  • Herzig, S., & Shaw, R. J. (2018). AMPK: guardian of metabolism and mitochondrial homeostasis. Nature reviews Molecular cell biology, 19(2), 121-135. Article
  • Gurd, B. J., Menezes, E. S., Arhen, B. B., & Islam, H. (2023, July). Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA. In Seminars in Cell & Developmental Biology (Vol. 143, pp. 17-27). Academic Press.
  • Juszczak, F., Caron, N., Mathew, A. V., & Declèves, A. E. (2020). Critical role for AMPK in metabolic disease-induced chronic kidney disease. International journal of molecular sciences, 21(21), 7994. Article
  • Khan, Y. S., & Farhana, A. (2020). Histology, cell.
  • Li, H., Liang, J., Han, M., & Gao, Z. (2024). Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review. Journal of Advanced Research. Article
  • Newman, T. (2023, December 19). What is a Cell? Medical News Today. Article 
  • Mohammadifard, N., Humphries, K. H., Gotay, C., Mena-Sánchez, G., Salas-Salvadó, J., Esmaillzadeh, A., ... & Sarrafzadegan, N. (2017). Trace minerals intake: risks and benefits for cardiovascular health. Critical reviews in food science and nutrition, 1-13. 
  • Pappas, A. C., Godlewska, K., & Surai, P. F. (2018). Dietary Food and Feed Supplements with Trace Elements. Recent Advances in Trace Elements, 421-441.
  • Richter, EA, Ruderman, NB.  (2009) AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 418(2):261-75.
  • Steinberg, G. R., & Kemp, B. E. (2009). AMPK in health and disease. Physiological reviews, 89(3), 1025-1078. Article
  • Reyes-Izquierdo, T., Shu, C., Argumedo, R., Nemzer, B., & Pietrzkowski, Z. (2014). The effect of elevATP™ on whole blood ATP levels: a single dose, crossover clinical study. J Aging Res Clin Practice, 3, 56-60.
  • Sotoudeheian, M., & Hoseini, S. (2023). Therapeutic properties of polyphenols affect AMPK molecular pathway in hyperlipidemia. Article
  • Xu, W., Luo, Y., Yin, J., Huang, M., & Luo, F. (2023). Targeting AMPK signaling by polyphenols: A novel strategy for tackling aging. Food & Function, 14(1), 56-73. Article
  • Zang, M., Xu, S., Maitland-Toolan, K. A., Zuccollo, A., Hou, X., Jiang, B., ... & Cohen, R. A. (2006). Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor–deficient mice. Diabetes, 55(8), 2180-2191. Article
  
  

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.  

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