Breast cancer is the most prevalent type of cancer among women worldwide.
Kuran et al.’s (2020) review, Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs, concludes that the properties of sulforaphane are promising and desirable in the context of its use as a supplement in the prevention of breast cancer. Kurgan et al made some strong statements in this review, worthwhile to read! Sulforaphanes can be used at every stage because it is not toxic and has a great ability to maintain normal homeostatic functions in the body.
Breast cancer is the most prevalent type of cancer among women worldwide. There are several recommended methods of breast cancer prevention, including chemoprevention. There are several approved drugs used to prevent breast cancer occurrence or recurrence and metastasizing. There are also a number of new substances undergoing clinical trials and at the stage of initial study. Studies suggest that dietary factors play a crucial role in breast cancer etiology. Epidemiological studies indicate that in particular vegetables from the Brassicaceae family are a rich source of chemopreventive substances, with sulforaphane (SFN) being one of the most widely studied and characterized. This review discusses potential applicability of SFN in breast cancer chemoprevention. A comprehensive review of the literature on the impact of SFN on molecular signalling pathways in breast cancer and breast untransformed cells is presented. The presented results of in vitro and in vivo studies show that this molecule has a potential to act as a preventive molecule either to prevent disease development or recurrence and metastasizing, and as a compound protecting normal cells against the toxic effects of cytostatics. Finally, the still scanty attempts to develop an improved analog are also presented and discussed.
Broccoli sprouts are the richest source of glucoraphanin which is the direct precursor to sulforaphane. Broccoli sulforaphane is one of the most potent inducers of phase II enzymes. Our Glucosinolates & Sulforaphanes is a powerhouse, providing a four fold increase in the phase 2 enzyme potential.
Kuran, D., Pogorzelska, A., & Wiktorska, K. (2020). Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs?. Nutrients, 12(6), 1559. Article
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New Dietary Guidelines from USA Government: Dietary-Guidelines-2020-2025
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