Rutledge, G. et. al., 2021 demonstrate that the addition of easily achievable quantities of blueberries to the diets of older adults significantly alters levels of circulating phenolic compounds which are related to improvements in cognition.
The researchers explored the metabolic fate of blueberries phenolics and their relationship to cognitive function after chronic (90 days) supplementation of freeze-dried blueberry (24g, equivalent to 1 cup of fresh blueberries) or control in a randomized, double-blind, parallel study with 38 healthy older adults (60-75 years).
Blood samples were collected at fasting (t = 0 h) and 2 h after a breakfast meal on days 0 (no treatment), 45, and 90, and a battery of cognitive tests was also conducted on these days.
Hippuric acid, phloroglucinaldehyde, syringic acid, ferulic acid-glucuronide, cyanidin-3-O-galactoside, cyanidin-3-O-glucoside, malvidin-3-O-galactoside, malvidin-3-O-glucoside, peonidin-3-O-xyloside, peonidin glucuronide, and petunidin-3-O-glucoside concentrations were significantly altered after 90 days of BB consumption compared to control.
Stepwise regression was used to assess the relationship between significantly altered concentrations of plasma phenolics and observed improvements in cognition.
Among participants in the blueberry group, changes in switch errors on the task-switching test (TST) from day 0 to 90 were associated with changes in postprandial levels of plasma ferulic acid-glucuronide, syringic acid, and malvidin-3-galactoside (R2 = 0.521, p < 0.05). Changes in repetition errors on the California Verbal Learning Test (CVLT-II) from day 0 to 90 were associated with changes in postprandial levels of ferulic acid-glucuronide, syringic acid, and hippuric acid (R2 = 0.807, p < 0.001).
These findings demonstrate that the addition of easily achievable quantities of blueberry to the diets of older adults significantly alters levels of circulating phenolic compounds which are related to improvements in cognition.
The BioImmersion Blueberry Extract is a very serious product, concentrating the phenolics of the whole fruit responsible for its therapeutic benefits. Each capsule contains 500mg of this precious extract, equivalent to one and a quarter cups of blueberries. In fact, it takes 80 lbs. of blueberries to get 1 lb. of this extract!
Recommended dose: 1-2 capsules daily.
- Rutledge, G. A., Sandhu, A. K., Miller, M. G., Edirisinghe, I., Burton-Freeman, B. B., & Shukitt-Hale, B. (2021). Blueberry phenolics are associated with cognitive enhancement in supplemented healthy older adults. Food & Function, 12(1), 107-118. Article
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Mary Ann Lila is the Director of The Plants For Health Institute at North Carolina State University. She is one of the seminal researchers in the use of blueberries, for human health.
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