Autism and Clostridia
Research ascribes various etiologies to Autism Spectrum Disorder (ASD). There are exogenous factors such as iatrogenic drugs, pollutants of various kinds, and over use of antibiotics; and there are the endogenous factors such as dysbiosis of the GI Tract, mitochondrial dysfunction, and of course genetics. Interestingly, genetic causation is found to be in the low percentile, whereas dybiosis and mitochondrial dysfunction conditions present major links to ASD.
Let’s focus on dysbiosis. Overgrowth of clostridia, bacteriodes, and desulfovibrio are all ASD-associated bacterial populations. The overuse of antibiotics enables the clostridial family of bacteria to dominate because their spore forming ability resist many antibiotics and they can easily gain a foothold over good bacteria.
Clostridia is a big producer of the SCFA propionate. Too much propionate in the systemic circulation (which is able to cross the blood-brain barrier) becomes neurological and mitochondrial toxins, disrupting and causing the very symptoms that we see with autistic patients.
There is strong support in the literature for foundational probiotic organisms that reduce the overload of clostridium. These are the organisms we have chosen for our probiotics.
Research is showing that L. plantarum, L. casei rhamnosus, B. longum and even L. acidophilus can put out bacterocins against clostridia. Doctors who have used our Original Synbiotic and our Supernatant Synbiotic (either one works) found improvement in the behaviors of ASD patients.
I would recommend adding Phyto Power for the high potency of polyphenolics grown in remote Alaskan regions. Phenols are shown in research as antimicrobials, inhibiting many pathogenic organisms including those implicated in ASD, yet at the same time, they enhance both the growth of the Bifido and Lactobacillus genera.
I suggest the following dosage:
Original Synbiotic: up to 1 tsp. daily. With very young patients start with an eight of a tsp and work up slowly adjusting the dosage. Back off just a little from a dosage that causes reaction. You be able to get up to a tsp dose in about a month of gradually ratcheting it up.
As a reminder this product contains L. plantarum, L. casei rhamnosus, L. acidophilus, B. longum and S. thermophiles plus organic chicory root inulin which is very bifido and lacto genic. Each of the organism are good butyrate produces, and as we know, butyrate helps to heal a leaky gut which is a big problem for ASD patients.
Phyto Power– 1 capsule daily (if they can’t take capsules then just open up the capsule and take the powder directly).
- Frye, R. E., Rose, S., Slattery, J., & MacFabe, D. F. (2015). Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microbial ecology in health and disease, 26(1), 27458. http://www.tandfonline.com/doi/full/10.3402/mehd.v26.27458%40zmeh20.2015.26.issue-s1?src=recsys
- MacFabe, D. F. (2015). Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders. Microbial ecology in health and disease, 26(1), 28177. http://email@example.com
- MacFabe, D. F. (2012). Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microbial ecology in health and disease, 23(1), 19260. http://www.tandfonline.com/doi/full/10.3402/mehd.v23i0.19260?src=recsys
- Wang, H., Lee, I. S., Braun, C., & Enck, P. (2016). Effect of probiotics on central nervous system functions in animals and humans: a systematic review. Journal of neurogastroenterology and motility, 22(4), 589. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056568/
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
©2005 – 2018 BioImmersion Inc. All Rights Reserved