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Mental Health: Probiotics, Prebiotics, Supernatant

This is a beautiful article that examines all aspects of Psychobiotics including diet (lots of veggies and fruit), probiotics, prebiotics (fiber), and post biotics or supernatant which is the metabolites probiotics make when they grow.

This is one reason Seann and I developed the No 7 Systemic Booster as the new longevity supplement. It is designed to supply a potent mix of needed nutrients along side ten probiotics with their supernatant and ORNS. It is a great bridge building between gut and brain.


Purpose: The gut microbiota has emerged as a key conduit in mental health and is a promising target for interventions. This review provides an update on recent advances in using microbiota-targeted approaches for the management of mental health.

Recent Findings: Approaches that have emerged as microbiota-targeted interventions in the management of mental health include probiotics, prebiotics, synbiotics, fecal microbiota transplant as well as diet. Among these approaches, probiotic supplementation has been investigated most prominently, providing promising evidence for its use in improving mood and anxiety. There is also growing interest in the use of multistrain probiotics, whole dietary interventions or combined approaches, with encouraging results emerging from recent studies.

Summary: Although the current literature preliminarily supports targeting the microbiota to manage mental health and use as adjuvant therapies for certain brain disorders, large gaps remain and especially data including clinical cohorts remains scarce. Research studies including larger cohorts, well-characterized clinical populations and defined duration and dosage of the intervention are required to develop evidence-based guidelines for microbiota-targeted strategies

No 7 Systemic Booster 

No 7 Systemic Booster has been formulated according to longevity research findings to support the specific dietary interventions to control and reduce both LGI and Immunosenescence.  

Suggested Dose:  One tsp daily.


  • Berding, K., & Cryan, J. F. (2022). Microbiota-targeted interventions for mental health. Current opinion in psychiatry, 35(1), 3. Article

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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 And more on depression:

Goh, K. K., Liu, Y. W., Kuo, P. H., Chung, Y. C. E., Lu, M. L., & Chen, C. H. (2019). Effect of probiotics on depressive symptoms: A meta-analysis of human studies. Psychiatry research, 282, 112568.

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