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2021 Meta Analysis: The Effect of Probiotics on IBD & Ulcerative Colitis

Are you suffering with Inflammatory Bowel Disease (IBD) or Ulcerative Colitis (UC)? This meta analysis shows promising results using probiotic formulas with prebiotic fibers (synbiotics).

In specific, formulas that have Lactobacillus and Bifidobacterium or more than one strain showed more success for IBD and UC. 



Probiotics have been reported to be beneficial for inflammatory bowel disease (IBD), but the types, number of strains, dosage, and intervention time of probiotics used remain controversial. Furthermore, the changes of gut microbiota in IBD’s patients are also intriguing. Thus, this meta-analysis was to explore the clinical effects and gut microbiota changes of using probiotics, prebiotics and synbiotics in IBD.


The search was performed in PubMed, Web of Science and the Cochrane library from inception to April 2020. Qualified randomized controlled trials were included. IBD’s remission rate, disease activity index and recurrence rate were extracted and analyzed. Changes in the gut microbiota of patients with IBD are comprehensively described.


Thirty-eight articles were included. Probiotics, prebiotics and synbiotics can induce/maintain IBD’s remission and reduce ulcerative colitis (UC) disease activity index (RR = 1.13, 95% CI 1.02, 1.26, P < 0.05; SMD = 1.00, 95% CI 0.27, 1.73, P < 0.05). In subgroup analyses of IBD remission rate and UC disease activity index, we obtained some statistically significant results in some subgroup (P < 0.05). To some extent, probiotic supplements can increase the number of beneficial bacteria (especially Bifidobacteria) in the intestinal tract of patients with IBD.


Our results support the treatment of IBD (especially UC) with pro/pre/synbiotics, and synbiotics are more effective. Probiotic supplements that are based on Lactobacillus and Bifidobacterium or more than one strain are more likely to be beneficial for IBD remission. The dose of 1010–1012 CFU/day may be a reference range for using probiotics to relieve IBD.


Original Synbiotic 

Original Synbiotic 

 Suggested use: One teaspoon by mouth (very tasty) or mixed in a little water. 


  • Zhang, X. F., Guan, X. X., Tang, Y. J., Sun, J. F., Wang, X. K., Wang, W. D., & Fan, J. M. (2021). Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in inflammatory bowel disease: A systematic review and meta-analysis. European journal of nutrition, 1-21. Abstract 
  • Wong, W. Y., Chan, B. D., Leung, T. W., Chen, M., & Tai, W. C. S. (2022). Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice. Journal of Functional Foods88, 104871. Article

Sincerely yours,

Dohrea and Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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 Antibiotics and inflammatory disease:

Feng, Y., Huang, Y., Wang, Y., Wang, P., Song, H., & Wang, F. (2019). Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy. PloS one14(6), e0218384. Article

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