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Working on the Microbiota-Gut-Brain Axis to Shift Depression

Gut-Brain axis is discussed in a more intensive way in the scientific literature. To understand various neurological conditions and behavioral patterns, we need to understand how different systems in the body communicate with each other.

More accurately, the Axis is actually is between the Microbiota-Gut-Brain (Kim & Kim, 2023).

It is not the "gut" that needs modulating but the community of organisms called the microbiota that we need to change with the right kind of psychobiotics. 

As we have discussed previously, psychobiotics are foundational probiotics, prebiotics - fiber such as inulin to feed these good organisms, and postbiotics, which is the 'soup' of metabolites that probiotics make when they grow. 

Kim & Kim just published in 2023 a chapter on major depression and the role of the microbiota in regulating emotions and behavior. It is not just the old programs in our mind/brain that cause depression but also the communities of organisms we have in our gut. 

Crosstalk between the brain and gut utilizing systems in the body such as the central (brain) and enteric (gut) onerous systems, the endocrine system, immune system, and metabolic system must function well.

Kim & Kim emphasize that when one system is down, the gut-brain axis suffers, which means it is not as simple to restore harmony to the microbiota-gut-brain connection (2023). Key here is to pay attention to all the different systems the brain and gut use for communication.

Boost the immune system, take care of the endocrine system - how about some relaxation and stress reduction (Athanasiou et al., 2022)? and ensure your diet supports a metabolic system. All contribute to the microbiota's health and in turn, the microbiota shifts depression and elevate the mood. 

The role of inflammation in general is also part of the depressive mode of the microbiota - gut - brain axis. Foundational probiotics, short chain fatty acids, a healthy diet all play an important role, as well as reducing sugar, toxins, and stress.

What is so encouraging in this 2023 chapter is that there is much that can be done, and the researchers go into the different markers, probiotics, and dietary changes that can therapeutically handle depression.

It is a fast paced article, interesting to read and as we know, going back to the basics is essential. Article

Original Synbiotic 

 Suggested use: One teaspoon by mouth (very tasty) or mixed in a little water. 


  • Athanasiou, N., Bogdanis, G. C., & Mastorakos, G. (2023). Endocrine responses of the stress system to different types of exercise. Reviews in Endocrine and Metabolic Disorders24(2), 251-266.
  • Kim, I. B., Park, S. C., & Kim, Y. K. (2023). Microbiota-Gut-Brain Axis in Major Depression: A New Therapeutic Approach. In Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders (pp. 209-224). Singapore: Springer Nature Singapore. Book-Chapter and Article

    Yours as Always,


    We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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     Probiotics and Depression: Palepu, M. S. K., & Dandekar, M. P. (2022). Remodeling of microbiota gut-brain axis using psychobiotics in depression. European Journal of Pharmacology, 175171. Abstract

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