Sulforaphane for anti-aging skin care?
It is exciting to see the accumulation of research on Sulforaphane's ability to care for different conditions of the skin, including the ability reverse sign of skin aging by strengthening and smoothing the skin.
A recent animal study with young mice (2 months) and old mice (21 month) found significant improvement in skin texture and thickness!
In fact, the old mice's skin looked like the young mice's skin after a diet of Sulforaphane.
What is the mechanism of this amazing improvement? Petkovic et al. conclude that it is the anti-inflammatory ability through the activation of Nrf2 pathway. I am sure we will continue to further learn the mechanism as we enjoy the results!
Visible impairments in skin appearance, as well as a subtle decline in its functionality at the molecular level, are hallmarks of skin aging. Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-pathway, which is important in controlling inflammation and oxidative stress that occur during aging, can be triggered by sulforaphane (SFN), an isothiocyanate found in plants from the Brassicaceae family. This study aimed to assess the effects of SFN intake on age-related skin alterations. Male C57BL6 young (2 months) and old (21 months) mice were treated for 3 months with SFN diet (442.5 mg per kg) or control diet. The antioxidant capacities of the skin were increased in old SFN-treated animals as measured by mRNA levels of Nrf2 (P<.001) and its target genes NQO1 (P<.001) and HO1 (P<.01). Protein expression for Nrf2 was also increased in old SFN fed animals (P<.01), but not the protein expression of NQO1 or HO1. Additionally, ROS and MMP9 protein levels were significantly decreased (P<.05) in old SFN fed animals. Histopathological analysis confirmed that there was no difference in epidermal thickness in old, when compared to young, SFN treated animals, while the dermal layer thickness was lower in old vs. young, treated animals (P<.05). Moreover, collagen deposition was improved with SFN treatment in young (P<.05) and structurally significantly improved in the old mice (P<.001). SFN dietary supplementation therefore ameliorates skin aging through activation of the Nrf2-pathway. Abstract
Each of our vegan capsule has 500 mg of organic broccoli sprouts, harvested at the peak of their phytonutrient power.
Suggested dose: 1-2 capsules a day, preferably before going to sleep.
Petkovic, M., Leal, E. C., Alves, I., Bose, C., Palade, P. T., Singh, P., ... & Carvalho, E. (2021). Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway. The Journal of Nutritional Biochemistry, 98, 108817. Abstract
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
And more on broccoli sprouts:
Du, P., Zhang, W., Cui, H., He, W., Lu, S., Jia, S., & Zhao, M. (2022). Sulforaphane Ameliorates the Severity of Psoriasis and SLE by Modulating Effector Cells and Reducing Oxidative Stress. Frontiers in pharmacology, 13, 805508-805508. Article
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