2021 Research: The “Big Five” Phytochemicals Targeting Cancer Stem Cells
Dear Friend,
Cancer stem cells (CSCs) constitute tumor cells that possess self-renewal and tumor initiation capacity. CSCs exhibit intrinsic mechanisms of resistance to virtually all conventional cancer therapeutics, allowing them to survive current cancer therapies and to initiate tumor recurrence and metastasis (Naujokat, C. & McKee, D. L., 2021).
Five phytochemicals, in particular curcumin, epigallocatechin-3-gallate (EGCG) found in green tea extract, sulforaphane, resveratrol and genistein have been shown to interfere with these intrinsic CSC pathways leading to the elimination of CSCs (Naujokat, C. & McKee, D. L., 2021).
We highly suggest you read the article for the chart of how these 5 Phyto chemicals work.
Abstract
Cancer stem cells (CSCs) constitute a subpopulation of tumor cells that possess self-renewal and tumor initiation capacity, and the ability to give rise heterogeneous lineages of cancer cells that comprise the tumor. CSCs exhibit intrinsic mechanisms of resistance to virtually all conventional cancer therapeutics, allowing them to survive current cancer therapies and to initiate tumor recurrence and metastasis. Different pathways and mechanisms that confer resistance and survival of CSCs, including activation of the Wnt/β-catenin, Sonic Hedgehog, Notch, PI3K/Akt/mTOR and STAT3 signaling pathways, expression of aldehyde dehydrogenase 1 (ALDH1) and oncogenic microRNAs, and acquisition of epithelialmesenchymal transition (EMT), have been identified recently. Certain phytochemicals, in particular curcumin, epigallocatechin-3-gallate (EGCG), sulforaphane, resveratrol and genistein have been shown to interfere with these intrinsic CSC pathways in vitro and in human xenograft mice, leading to the elimination of CSCs. Moreover, recent clinical trials have demonstrated the therapeutic efficacy of the five phytochemicals, alone or in combination with modern cancer therapeutics, and in various types of cancer. Since current cancer therapies fail to eradicate CSCs, leading to cancer recurrence and progression, targeting CSCs with phytochemicals such as curcumin, EGCG, sulforaphane, resveratrol and genistein, combined with each other and/or in combination with conventional cytotoxic drugs and novel cancer therapeutics, may offer a novel therapeutic strategy against cancer. Article
Broccoli sprouts are the richest source of glucoraphanin which is the direct precursor to sulforaphane. Broccoli sulforaphane is one of the most potent inducers of phase II enzymes. Our Glucosinolates & Sulforaphanes is a powerhouse, providing a four fold increase in the phase 2 enzyme potential.
Glucosinolates & Sulforaphanes
References
Naujokat, C., & McKee, D. L. (2021). The “Big Five” phytochemicals targeting cancer stem cells: curcumin, EGCG, sulforaphane, resveratrol, and genistein. Current medicinal chemistry. Article
Sincerely yours,
Seann
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Green Facts:
 New Dietary Guidelines from USA Government: Dietary-Guidelines-2020-2025
|
|
©2005 - 2021 BioImmersion Inc. All Rights Reserved
|