Cranberry Pomegranate Synbiotic has high concentrations of polyphenols with compounds that inhibit pathogenic invaders, such as E. coli and staphylococcus aureus, two known bacteria that cause bladder infections (Gbinigie et al., 2021; González et al., 2020; 2019).
Cranberries have excellent anti adhesive and antimicrobial properties that inhibit and manage UTIs (Scharf et al., 2020; Gbinigie et al., 2021; Jensen et al., 2017), while Pomegranates contain 124 different phyto-nutrients and a high concentration of polyphenols that wield an inhibitory effect on pathogenic Staphylococcus aureus. In fact, Pomegranates have enjoyed an exalted status since ancient times (Pagliarulo et al., 2016; Parseh et al., 2012).
Together with the “anti-infective activities” of lactobacillus strains (Liévin-Le Moal et al., 2014), and especially for recurrent UTIs (Manzoor et al., 2016), the probiotics, Supernatant and MicroRNAs, add a potent antimicrobial supports to a healthy urogenital system.
Bader (2017) update on the status of urinary tract infections (UTIs) emphasizes the growing concern of UTIs caused by antibiotic-resistant Gram-negative bacteria, such as E. coli, Salmonella, Klebeiella– all part of the family Enterobacteriaceae. Treating UTIs with drugs like Fosfomycin tromethamine, amoxicillin, and others are the typical course of action, but what do we do when these drugs do not resolve the UTI?
Proanthocyanidins from Cranberries and Pomegranates have been used for many years as anti-adhesive agents in the treatment of UTI. Gupta et al. (2012) showed in his study that a drug resistant E. coli was sensitive to an extract from cranberries on bladder infection by inhibiting the adhesiveness of multi-drug resistant E. coli to the walls. In 2015 Kaspar et al. assessed the anti-adhesion effect of cranberry extract to improve urinary tract health. More recently, the research and reviews of Lima et al. (2019) and González de Llanoet al. (2019) showed new findings on the efficacy of cranberries against urinary tract infections due to the rich source of phenolic compounds.
- Bader, M. S., Loeb, M., & Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine, 129(2), 242-258.
- Gbinigie, O. A., Spencer, E. A., Heneghan, C. J., Lee, J. J., & Butler, C. C. (2021). Cranberry Extract for Symptoms of acute, Uncomplicated Urinary Tract Infection: A Systematic Review. Antibiotics, 10(1), 12.
- González de Llano, D., Liu, H., Khoo, C., Moreno-Arribas, M. V., & Bartolomé, B. (2019). Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria. Journal of agricultural and food chemistry, 67(8), 2166-2174.
- Gupta, A., Dwivedi, M., Mahdi, A.A., Nagana Gowda, G.A., Khetrapal, C.L., Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin. Urol Res, 40(2), 143-50.
- Jensen, H.D., Carsten, S., Christensen, S.B., & Krogfelt, K.A. (2017). Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. Front Microbiol, 8, 542.
- Kaspar, K.L., Howell, A.B., & Khoo, C. (2015). A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages.Food Funct, 6(4), 1212-7.
- Liévin-Le Moal, V., & Servin, A. L. (2014). Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clinical microbiology reviews, 27(2), 167-199.
- Lima, M. C., de Sousa, C. P., Fernandez-Prada, C., Harel, J., Dubreuil, J. D., & de Souza, E. L. (2019). A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria. Microbial pathogenesis.
- Manzoor, A., Ul-Haq, I., Baig, S., Qazi, J. I., & Seratlic, S. (2016). Efficacy of locally isolated lactic acid bacteria against antibiotic-resistant uropathogens. Jundishapur journal of microbiology, 9(1).
- Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831.
- Parseh, H., Hassanpour, S., Emam-Djome, Z., Lavasani, A. S., Mahmoodabady, H. Z., CHabok, M., … & Ghahsareh, A. M. (2012, April). Antimicrobial properties of Pomegranate (Punica granatum L.) as a Tannin rich Fruit: a review. In The 1st International and The 4th National Congress on Recycling of Organic Waste in Agriculture. Iran.
- Rodríguez-Pérez, C., Quirantes-Piné, R., Uberos, J., Jiménez-Sánchez, C., Peña, A., & Segura-Carretero, A. (2016). Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli. Food & function, 7(3), 1564-1573.
- Scharf, B., Schmidt, T. J., Rabbani, S., Stork, C., Dobrindt, U., Sendker, J., ... & Hensel, A. (2020). Antiadhesive natural products against uropathogenic E. coli: What can we learn from cranberry extract?. Journal of ethnopharmacology, 257, 112889.
- Wafa, B. A., Makni, M., Ammar, S., Khannous, L., Hassana, A. B., Bouaziz, M., … & Gdoura, R. (2017). Antimicrobial effect of the Tunisian Nana variety Punica granatum L. extracts against Salmonella enterica (serovars Kentucky and Enteritidis) isolated from chicken meat and phenolic composition of its peel extract. International journal of food microbiology, 241, 123-131.
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